Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe

Racine, Antoine; Carbonnel, Franck; Chan, Simon; Hart, Andrew; Bueno-De-Mesquita, H. Bas; Oldenburg, Bas; Schaik, Fiona D.M. van; Tjønneland, Anne; Olsen, Anja; Dahm, Christina C.; Key, Timothy J.; Luben, Robert; Khaw, Kay Tee; Riboli, Elio; Grip, Olof; Lindgren, Stefan; Hallmans, Göran; Karling, Pontus; Clavel‐Chapelon, Françoise; Bergman, Manuela; Boeing, Heiner; Kaaks, Rudolf; Katzke, Verena; Palli, Domenico; Masala, Giovanna; Jantchou, P; Boutron-Ruault, Marie Christine

doi:10.1097/mib.0000000000000638

Cited by 230 publications

(184 citation statements)

References 67 publications

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“…Cola drinks and chocolate are rich in carbohydrates and fats, and in the study of Russel et al, both were found in positive association with the development of CD (OR (95% CI): 2.2 (1.5–3.1); 2.5 (1.8–3.5)) [30]. However, in the Racine et al study, the dietary pattern of “high sugar and soft drinks” showed no significant association with CD risk (the highest vs. the lowest category: RR (95% CI): 1.48 (0.60–3.61)), as well as the pattern “animal fats, seafood, potatoes and alcohol” (RR (95% CI): 0.71 (0.29–1.73)) [31]. It was controversial on the role of these macronutrients in the development of CD, and environmental and genetic factors might contribute to the inconsistency in findings between studies [32,33].…”

Section: Discussionmentioning

confidence: 99%

Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies

Zeng

Chen

et al. 2017

Nutrients

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Dietary intake is potentially associated with the onset of Crohn’s disease (CD), but evidence from epidemiological studies has remained unclear. This study aimed to evaluate the role of macronutrient intake in the development of CD. A systematic search was conducted in PubMed and Web of Science to identify all relevant studies, and the role of macronutrients in the development of CD was quantitatively assessed by dose–response meta-analysis. Four case-control studies (a total of 311 CD cases and 660 controls) and five prospective cohort studies (238,887 participants and 482 cases) were identified. The pooled relative risks (RR) for per 10 g increment/day were 0.991 (95% confidence interval (CI): 0.978–1.004) for total carbohydrate intake, 1.018 (95% CI: 0.969–1.069) for total fat intake, and 1.029 (95% CI: 0.955–1.109) for total protein intake. Fiber intake was inversely associated with CD risk (RR for per 10 g increment/day: 0.853, 95% CI: 0.762–0.955), but the association was influenced by study design and smoking adjustment. In subtypes, sucrose intake was positively related with CD risk (RR for per 10 g increment/day: 1.088, 95% CI: 1.020–1.160). Non-linear dose–response association was also found between fiber and sucrose intake and CD risk. In conclusion, this meta-analysis suggested a lack of association between total carbohydrate, fat or protein intake and the risk of CD, while high fiber intake might decrease the risk. In subtypes, high sucrose intake might increase the risk of CD.

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Section: Discussionmentioning

confidence: 99%

Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies

Zeng

Chen

et al. 2017

Nutrients

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“…In contrast, no association was found between fiber consumption and the risk of developing IBD in Asia . In the EPIC‐IBD cohort, a diet rich in sugar and soft drinks was associated with an increased risk of developing UC (incidence rate ratio 1.68; 95%CI 1–2.82) .…”

Section: Disease Course Of Ibdmentioning

confidence: 91%

The epidemiology of inflammatory bowel disease: East meets west

Mak

Zhao

et al. 2019

J of Gastro and Hepatol

445

291

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The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade to become a global disease. The increasing number of studies on the incidence and course of IBD in East has enabled us to explore East versus West differences in the epidemiology of IBD which could enhance our understanding of the heterogeneity of the disease and eventually assist in the discovery of novel therapeutic targets and design of preventive strategies. Comparison of population‐based data in East and West reveals that the incidence of IBD has risen rapidly in East while plateauing in West. Furthermore, the clinical presentation and course of IBD differs between East and West with more patients in East presenting with complicated disease. Considering the scarcity of population‐based data from East and the lack of studies with long durations of follow‐up, it remains to be clarified whether these differences reflect true differences in disease presentation. The effects of genetic and environmental risk factors contributing to IBD also differ between Eastern and Western populations. Considering the differential effects of genetic and environmental risk factors in East and West, future studies should seek to discover novel genetic and environmental risk factors which might specifically apply to eastern populations. In this narrative review, we compare the epidemiology of IBD between eastern and western countries by summarizing evidence from population‐based cohort studies in the last ten years. Furthermore, we look at differences in genetic susceptibility and environmental triggers of IBD between East and West.

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“…High vegetable intake may be associated with decreased risk of UC (OR range 0.32–0.75) [22]. The European Investigation into Cancer and Nutrition study ( n = 366,351 with 256 incident cases of UC and 117 of CD, and four matched controls per case) reported that an increased consumption of sugar and soft drinks with low vegetable intake was positively associated with UC risk (OR 1.31, 95% CI: 0.85–2.02; p = 0.05) [25]. Increased consumption of sweets is positively associated with CD (OR: 2.83, 95% CI: 1.38–5.83) and UC (OR: 2.86, 95% CI: 1.24–6.57) [30].…”

Section: Diet In the Etiology Of Ibdmentioning

confidence: 99%

An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

Haskey

Gibson

2017

Nutrients

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Diet has been speculated to be a factor in the pathogenesis of inflammatory bowel disease and may be an important factor in managing disease symptoms. Patients manipulate their diet in attempt to control symptoms, often leading to the adoption of inappropriately restrictive diets, which places them at risk for nutritional complications. Health professionals struggle to provide evidence-based nutrition guidance to patients due to an overall lack of uniformity or clarity amongst research studies. Well-designed diet studies are urgently needed to create an enhanced understanding of the role diet plays in the management of inflammatory bowel disease. The aim of this review is to summarize the current data available on dietary management of inflammatory bowel disease and to demonstrate that dietary modulation may be an important consideration in managing disease. By addressing the relevance of diet in inflammatory bowel disease, health professionals are able to better support patients and collaborate with dietitians to improve nutrition therapy.

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Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe

Cited by 230 publications

References 67 publications

Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies

Macronutrient Intake and Risk of Crohn’s Disease: Systematic Review and Dose–Response Meta-Analysis of Epidemiological Studies

The epidemiology of inflammatory bowel disease: East meets west

An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

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