The prevalence of metabolic syndrome is raising worldwide; however, the role of diet in the origin of metabolic syndrome is not understood well. This study was conducted to determine the association between Healthy Eating Index-2010 (HEI-2010) with metabolic syndrome and its components among type 2 diabetes patients in Gaza Strip, Palestine. This cross sectional study was conducted among 1187 previously diagnosed type 2 diabetes mellitus (both genders, aged 20-64 years), patients receiving care in primary healthcare centers in Gaza Strip, Palestine. A validated semi-quantitative food frequency questionnaire was used to assess the dietary intakes of patients. HEI-2010 was used to assess diet quality of patients. Metabolic syndrome was defined based on the International Diabetes Federation criteria. Additional information regarding demographic and medical history variables was obtained with an interview-based questionnaire. Statistical analysis was performed using SPSS version 20. After adjustment for potential confounders, patients in the lowest quartile (Q1) of HEI-2010 had the highest risk of (Metabolic syndrome, central obesity, high triglycerides, low HDL-cholesterol and high blood pressure), (Odds ratio [OR] =1.804, 95% confidence interval [CI] = [1.494-2.178]), (OR = 1.351, 95% CI = [1.077-1.694]), (OR = 2.270, 95% CI = [1.911-2.697]), (OR = 2.089, 95% CI = [1.763-2.475]), (OR = 1.361, 95% CI = [1.145-1.618]), respectively, (P value < 0.005 for all), compared with those in the upper quartile (Q4). In conclusion, the highest HEI-2010 score may be associated with a lower prevalence of metabolic syndrome and its components among type 2 diabetes patients.El Bilbeisi AH (2019) Association of healthy eating index with metabolic syndrome and its components among type 2 diabetes patients in Gaza Strip, Palestine: A cross sectional study