Dietary patterns based on the Mediterranean diet and DASH diet are inversely associated with high aggressive prostate cancer in PCaP

Schneider, Lara; Su, L. Joseph; Arab, Lenore; Bensen, Jeannette T.; Farnan, Laura; Fontham, Elizabeth T.H.; Song, Lixin; Hussey, James R.; Merchant, Anwar T.; Mohler, James L.; Steck, Susan E.

doi:10.1016/j.annepidem.2018.08.012

Cited by 36 publications

(26 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies conducted by Kenfield and Richard respectively, confirmed the presence of a strong relationship between diet pattern and prostate cancer risk. Both demonstrated as PCa was less widespread in Mediterranean area than in the Northern Europe ones [115,116]: A high MD adherence not only was inversely associated with a low incidence of prostate cancer, but also it was associated with lower cancer malignancy (44%, OR high score vs. low score = 0.66, 95% CI: 0.46–0.95) [114] and mortality rate for PCa (22%, HR = 0.78, 95% CI: 0.67–0.90) in patients without metastasis [115]. Overall, a high MD score was associated with a low likelihood of PCa (OR = 0.86, 95% CI: 0.77–0.96); thereby, PCa risk decreased until 78% in subjects with the highest MD scores, registering in particular a decrease of 14% for each one-point increase of MD score [85].…”

Section: Impact Of Mediterranean Diet On Cancermentioning

confidence: 99%

Cancer and Mediterranean Diet: A Review

et al. 2019

View full text Add to dashboard Cite

The Mediterranean diet is considered one of the most worldwide healthy dietary patterns thanks to a combination of foods rich mainly in antioxidants and anti-inflammatory nutrients. Many studies have demonstrated a strong and inverse relationship between a high level of Mediterranean diet adherence and some chronic diseases (such as cardiovascular diseases, diabetes, etc.) and cancer. Given its protective effects in reducing oxidative and inflammatory processes of cells and avoiding DNA damages, cell proliferation, and their survival, angiogenesis, inflammations and metastasis, the Mediterranean diet is considered a powerful and manageable method to fight cancer incidence. The aim of this narrative review was to determine the magnitude of interaction between the Mediterranean diet and more widespread types of cancer so as to give a first and useful overview on this relationship identifying, with a nutritional approach, those nutrients of Mediterranean diet able to reduce cancer incidence.

show abstract

Section: Impact Of Mediterranean Diet On Cancermentioning

confidence: 99%

Cancer and Mediterranean Diet: A Review

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Several evidences highlight that MD reduces overall risk of cancer, in a dose-response manner [189]. More specifically, MD has been associated with reduced incidence of colorectal [190], gastric [191], high aggressive prostate [192] and breast cancer [193], and particularly receptor negative breast cancer in post-menopausal women [194]. Moreover, MD has been favorably associated with reduced cancer mortality [195].…”

Section: Lifestyle Interventions-let Food Be Your Medicinementioning

confidence: 99%

Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis

2021

View full text Add to dashboard Cite

The prevalence of being overweight and obese has been expanded dramatically in recent years worldwide. Obesity usually occurs when the energetic introit overtakes energy expenditure from metabolic and physical activity, leading to fat accumulation mainly in the visceral depots. Excessive fat accumulation represents a risk factor for many chronic diseases, including cancer. Adiposity, chronic low-grade inflammation, and hyperinsulinemia are essential factors of obesity that also play a crucial role in tumor onset. In recent years, several strategies have been pointed toward boundary fat accumulation, thus limiting the burden of cancer attributable to obesity. While remodeling fat via adipocytes browning seems a tempting prospect, lifestyle interventions still represent the main pathway to prevent cancer and enhance the efficacy of treatments. Specifically, the Mediterranean Diet stands out as one of the best dietary approaches to curtail visceral adiposity and, therefore, cancer risk. In this Review, the close relationship between obesity and cancer has been investigated, highlighting the biological mechanisms at the basis of this link. Finally, strategies to remodel fat, including browning and lifestyle interventions, have been taken into consideration as a major perspective to limit excess body weight and tumor onset.

show abstract

“…The MD score was then computed as the sum of scores across the 9 components with a total score range of 0 to 9,with a higher score indicative of increased adherence to MD. Results were similar upon consideration of another version of the MD that does not differentiate whole grains from total grains or cereals 25,26 …”

Section: Methodsmentioning

confidence: 81%

“…Several epidemiological studies have investigated the association between a priori or index‐based dietary patterns and the risk of PCa 8,31,32 . A lower risk of aggressive PCa was reported in men who adhered to the MD in the Multicase‐Control Study on Common Tumors in Spain cohort 7 and the North Carolina–Louisiana Prostate Cancer Project, 26 although findings have been mixed in recent meta‐analyses 3,33 . Interestingly, an analysis of the MD in the Health Professional Follow‐Up cohort did not show an association between an increased MD score and prostate‐related death, 8 although an overall survival benefit was noted.…”

Section: Discussionmentioning

confidence: 99%

Adherence to the Mediterranean diet and grade group progression in localized prostate cancer: An active surveillance cohort

Gregg

Zhang

Chapin

et al. 2021

Cancer

View full text Add to dashboard Cite

Background The Mediterranean diet (MD) may be beneficial for men with localized prostate cancer (PCa) on active surveillance (AS) because of its anti‐inflammatory, antilipidemic, and chemopreventive properties. This study prospectively investigated adherence to the MD with Gleason score progression and explored associations by diabetes status, statin use, and other factors. Methods Men with newly diagnosed PCa on an AS protocol (n = 410) completed a baseline food frequency questionnaire, and the MD score was calculated across 9 energy‐adjusted food groups. Cox proportional hazards models were fit to evaluate multivariable‐adjusted associations of the MD score with progression‐free survival; progression was defined as an increase in the Gleason grade group (GG) score over a biennial monitoring regimen. Results In this cohort, 15% of the men were diabetic, 44% of the men used statins, and 76 men progressed (median follow‐up, 36 months). After adjustments for clinical factors, higher adherence to the MD was associated with a lower risk of GG progression among all men (hazard ratio [HR] per 1‐unit increase in MD score, 0.88; 95% confidence interval [CI], 0.77‐1.01), non‐White men (HR per 1‐unit increase in MD score, 0.64; 95% CI, 0.45‐0.92; P for interaction = .07), and men without diabetes (HR per 1‐unit increase in MD score, 0.82; 95% CI, 0.71‐0.96; P for interaction = .03). When joint effects of the MD score and statin use were examined, a similar risk reduction was observed among men with high MD scores who did not use statins in comparison with men with low/moderate MD scores with no statin use. Conclusions The MD is associated with a lower risk of GG progression in men on AS, and this is consistent with prior reports about the MD and reduced cancer morbidity and mortality.

show abstract

Dietary patterns based on the Mediterranean diet and DASH diet are inversely associated with high aggressive prostate cancer in PCaP

Cited by 36 publications

References 39 publications

Cancer and Mediterranean Diet: A Review

Cancer and Mediterranean Diet: A Review

Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis

Adherence to the Mediterranean diet and grade group progression in localized prostate cancer: An active surveillance cohort

Contact Info

Product

Resources

About