Dietary phytochemical approaches to stem cell regulation

Zhang, Shuai; Lam, Kargo Kar Ho; Wan, Jack Hei; Yip, Chun Wang; Liu, Harry Kwun Hung; Lau, Queenie Ming Ngai; Man, Alice Hei Yi; Cheung, Chun Hei Antonio; Wong, Lik Hang; Chen, Hubiao; Shi, Jun; Leung, George Pak-Heng; Lee, Ckf; Shi, Yi; Tang, Sydney Chi Wai; Zhang, Kalin Yan Bo

doi:10.1016/j.jff.2020.103822

Cited by 13 publications

(11 citation statements)

References 208 publications

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“… 3 , 4 , 68 , 69 Some reports are showing that phenolic and flavonoid components of plants can promote proliferation and differentiation of stem cells through activating signaling pathways and inducing gene expression. 70 , 71 , 72 A natural flavonoid, apigenin, stimulated osteogenic differentiation of human MSCs by activating the JNK and p38 MAPK signal pathways. 70 Some reports confirmed that flavonoid quercetin induced osteogenic and pancreatic β-cell differentiation of MSCs.…”

Section: Discussionmentioning

confidence: 99%

Trans-differentiation of mouse mesenchymal stem cells into pancreatic β-like cells by a traditional anti-diabetic medicinal herb Medicago sativa L

Mansourzadeh

Esmaeili

Shabani

et al. 2022

Journal of Traditional and Complementary Medicine

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Section: Discussionmentioning

confidence: 99%

Trans-differentiation of mouse mesenchymal stem cells into pancreatic β-like cells by a traditional anti-diabetic medicinal herb Medicago sativa L

Mansourzadeh

Esmaeili

Shabani

et al. 2022

Journal of Traditional and Complementary Medicine

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“…Stem cells belong to four major categories based on their differentiation potential (Figure 1). 29 Totipotent cells, such as zygotes and early blastomeres, can generate the whole organism and represent a subset of stem cells with a huge differentiation potential; however, to date, these have not been successfully isolated and cultured in vitro. 30 Pluripotent cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), can differentiate into any tissue-specific adult body cell.…”

Section: Stem Cell Sourcesmentioning

confidence: 99%

Optimizing Stem Cell Therapy after Ischemic Brain Injury

et al. 2020

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Stem cells have been used for regenerative and therapeutic purposes in a variety of diseases. In ischemic brain injury, preclinical studies have been promising, but have failed to translate results to clinical trials. We aimed to explore the application of stem cells after ischemic brain injury by focusing on topics such as delivery routes, regeneration efficacy, adverse effects, and <i>in vivo</i> potential optimization. PUBMED and Web of Science were searched for the latest studies examining stem cell therapy applications in ischemic brain injury, particularly after stroke or cardiac arrest, with a focus on studies addressing delivery optimization, stem cell type comparison, or translational aspects. Other studies providing further understanding or potential contributions to ischemic brain injury treatment were also included. Multiple stem cell types have been investigated in ischemic brain injury treatment, with a strong literature base in the treatment of stroke. Studies have suggested that stem cell administration after ischemic brain injury exerts paracrine effects via growth factor release, blood-brain barrier integrity protection, and allows for exosome release for ischemic injury mitigation. To date, limited studies have investigated these therapeutic mechanisms in the setting of cardiac arrest or therapeutic hypothermia. Several delivery modalities are available, each with limitations regarding invasiveness and safety outcomes. Intranasal delivery presents a potentially improved mechanism, and hypoxic conditioning offers a potential stem cell therapy optimization strategy for ischemic brain injury. The use of stem cells to treat ischemic brain injury in clinical trials is in its early phase; however, increasing preclinical evidence suggests that stem cells can contribute to the down-regulation of inflammatory phenotypes and regeneration following injury. The safety and the tolerability profile of stem cells have been confirmed, and their potent therapeutic effects make them powerful therapeutic agents for ischemic brain injury patients.

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“…The differentiation of SCs is determined by growth factors involved in triggering specific signaling pathways. Wingless‐related integration site (Wnt), transforming growth factor‐beta (TGF‐ β ), Notch, Hedgehog and tyrosine kinase are the principal pathways involved in modulating the fate of SCs 15 . Growth factors including sonic hedgehog and retinoic acid are necessary for early differentiation to guide ectodermal lineage; whereas for late differentiation, neurotrophic factors like brain‐derived neurotrophic factor (BDNF) and neurotrophin‐3 provide neuroprotection to improve cell survival 16 …”

Section: Effect Of Plant Derivatives On Stem Cell Differentiationmentioning

confidence: 99%

“…Winglessrelated integration site (Wnt), transforming growth factor-beta (TGF-⊎), Notch, Hedgehog and tyrosine kinase are the principal pathways involved in modulating the fate of SCs. 15 Growth factors including sonic hedgehog and retinoic acid are necessary for early differentiation to guide ectodermal lineage; whereas for late differentiation, neurotrophic factors like brain-derived neurotrophic factor (BDNF) and neurotrophin-3 provide neuroprotection to improve cell survival. 16 In the case of mesodermal lineage, the roles of activin and bone morphogenetic protein (BMP) are crucial for differentiation.…”

Section: Effect Of Plant Derivatives On Stem Cell Differentiationmentioning

confidence: 99%

Stem cell culture media enriched with plant‐derived compounds: Cell differentiation enhancement

Chairez‐Cantu

Ornelas‐González

Ortiz‐Martínez

et al. 2021

J of Chemical Tech & Biotech

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The development of cell therapies to replace lost or damaged cells has attracted interest in the regenerative medicine field due to the multilineage differentiation ability of stem cells. However, there are some drawbacks regarding optimization in the differentiation protocols to obtain high efficiency and further translation into clinic settings, which have led to the identification of specific compounds that could overcome these challenges. For years, plants have been associated with useful therapeutic effects for the treatment of some human diseases due to their high content of bioactive compounds. These plant derivatives act as growth factors that could either modulate or promote cell differentiation by the activation of specific signaling pathways. In this context, the administration of stem cells supplemented with these compounds could have better outcomes as a treatment. Hence, supplementing stem cell culture with plant derivatives represents a cost‐effective strategy, as the purification of plant extracts is of relatively low cost compared to the production of recombinant growth factors, and also their use facilitates the compliance of good manufacturing practice guidelines compared to xenogeneic compounds. This review aims to describe the mechanism of action of the most well‐studied plant derivatives involved in cell differentiation enhancement, particularly in osteogenic and neural lineages. Additionally, current trends and challenges that must be addressed for successful implementation in clinical applications are discussed. © 2021 Society of Chemical Industry (SCI).

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Dietary phytochemical approaches to stem cell regulation

Cited by 13 publications

References 208 publications

Trans-differentiation of mouse mesenchymal stem cells into pancreatic β-like cells by a traditional anti-diabetic medicinal herb Medicago sativa L

Trans-differentiation of mouse mesenchymal stem cells into pancreatic β-like cells by a traditional anti-diabetic medicinal herb Medicago sativa L

Optimizing Stem Cell Therapy after Ischemic Brain Injury

Stem cell culture media enriched with plant‐derived compounds: Cell differentiation enhancement

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