Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women; a cross-sectional study

Kreijkamp-Kaspers, Sanne; Kok, Linda; Bots, Michiel L.; Grobbee, Diederick E.; Schouw, Yvonne T. van der

doi:10.1016/j.atherosclerosis.2004.06.002

Cited by 27 publications

(10 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, serum total cholesterol and LDL-cholesterol concentrations were not found to be different between the quartiles. In a study of post-menopausal women Kreijkamp-Kaspers et al (2005) have shown a trend for lower total cholesterol and LDL-cholesterol concentrations across tertiles of lignan intake that again was not significant. In a recent analysis of a subgroup of subjects from the Health Professionals Follow-up Study van der Schouw et al (2005) have reported that concentrations of LDL-cholesterol and apoB tend to increase across quartiles of increasing lignan intake (for LDL-cholesterol: from quartile 4 to quartile 1, 9%; P = 0 .…”

Section: Mammalian Lignans and Whole Grainsmentioning

confidence: 89%

Whole grains and CVD risk

Seal

2006

Proc. Nutr. Soc.

109

View full text Add to dashboard Cite

There is an increasing body of evidence, including that from prospective population studies and epidemiological observational studies, suggesting a strong inverse relationship between increased consumption of wholegrain foods and reduced risk of CVD. This evidence has translated into specific dietary recommendations in the USA to consume at least three servings of whole grain per d, and has informed the development of specific health claims for wholegrain foods both in the USA and in Europe. Wholegrain foods are rich sources of many nutrients and phytochemicals, including complex carbohydrates, dietary fibre, minerals, vitamins, antioxidants and phyto-oestrogens such as lignans. Many of these components are lost from the grain during processing and although some may be replaced (such as in the mandatory fortification of white flour), this practice ignores the possible synergistic effects of the ‘natural’ constituents. The notion that wholegrain foods are simply a source of dietary fibre has been dispelled, although the additional components that contribute to the health benefits have not been clearly identified. In addition, the mechanisms by which wholegrain foods may have their effect are poorly understood. At present there are few strictly-controlled intervention studies that have confirmed a beneficial effect of increased consumption of wholegrain foods, demonstrated the level of consumption required to elicit a beneficial effect or provided evidence of modes of action. Although wholegrain foods are considered amongst the healthiest food choices available, their consumption falls well below current recommendations, which have been based mainly on epidemiological evidence. Well-controlled intervention studies are needed to provide more detailed mechanistic evidence to support the health claims and findings which can be used to develop effective public health strategies to promote whole-grain consumption.

show abstract

Section: Mammalian Lignans and Whole Grainsmentioning

confidence: 89%

Whole grains and CVD risk

Seal

2006

Proc. Nutr. Soc.

109

View full text Add to dashboard Cite

show abstract

“…75 One study did find significantly lower lipoprotein (a) levels with higher habitual isoflavone intake. 76 It is believed that Lp(a) is a strong risk factor for atherosclerotic heart disease and has been associated with premature CVD. 76 In addition to their effect on menopause, some studies show that the excretion of phytoestrogen is associated with a substantial reduction in breast cancer risk.…”

Section: Phytoestrogensmentioning

confidence: 99%

“…76 It is believed that Lp(a) is a strong risk factor for atherosclerotic heart disease and has been associated with premature CVD. 76 In addition to their effect on menopause, some studies show that the excretion of phytoestrogen is associated with a substantial reduction in breast cancer risk. Thus, the action of these phytoestrogens may be different in some respects from estradiol, which has been associated with a slight increase in breast cancer risk.…”

Section: Phytoestrogensmentioning

confidence: 99%

Role of Exercise and Nutrition in Menopause

Hagey

Warren

2008

Clinical Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

show abstract

“…Isoflavone is a phenolic phytoestrogen that is widely distributed in the leguminosae family. R. puerariae has been demonstrated to contain a series of isoflavones which possess multiple health benefits for human body including prevention of sex hormone‐related ailments 4, 5, cancer 6, 7, cardiovascular diseases 8, 9 and bone loss 10. Furthermore, more than 30 isoflavones were identified in different species of R. puerariae 11.…”

Section: Introductionmentioning

confidence: 99%

Rapid simultaneous determination of isoflavones in Radix puerariae using high‐performance liquid chromatography–triple quadrupole mass spectrometry with novel shell‐type column

Zhao

Song

et al. 2011

J of Separation Science

View full text Add to dashboard Cite

A high-performance liquid chromatography (HPLC) coupled with triple quadrupole mass spectrometry (MS/MS) method was developed for rapid determination of 13 isoflavones in Radix puerariae. A novel shell-type column, namely Kinetex core-shell C(18) column (50 mm×2.1 mm id, 2.6 μm), and gradient elution were used during the analysis. The chromatographic peaks of 13 investigated compounds were identified by comparing their retention time and MS data with the related reference compounds. Multiple-reaction monitoring (MRM) was employed for the quantitative analysis with negative ionization mode. All calibration curves showed good linearity (r(2)>0.9990) within test ranges. The LOD and LOQ were lower than 0.017 and 0.873 μg/mL on column, respectively. The intra- and inter-day precisions for 13 analytes were <1.17 and 2.17%, respectively, and the recoveries were 93.1-104.4%. The validated method was applied for quantitative analysis of 13 isoflavones in 7 species of Radix puerariae. The result demonstrated that HPLC-MS/MS system with Kinetex column could be a promising analytical tool for the determination of isoflavones in traditional Chinese medicines, which is helpful for comprehensive evaluation of quality of R. puerariae.

show abstract

Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women; a cross-sectional study

Cited by 27 publications

References 32 publications

Whole grains and CVD risk

Whole grains and CVD risk

Role of Exercise and Nutrition in Menopause

Rapid simultaneous determination of isoflavones in Radix puerariae using high‐performance liquid chromatography–triple quadrupole mass spectrometry with novel shell‐type column

Contact Info

Product

Resources

About