2020
DOI: 10.1016/bs.apcsb.2019.08.006
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Dietary plant flavonoids in prevention of obesity and diabetes

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Cited by 84 publications
(52 citation statements)
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“…Thus, at present, it is considered that the most efficient approach to prevent or delay T2D and obesity is the reduction of sedentarism and changes in dietary habits. In this regard, flavonoids, which are natural dietary compounds abundant in vegetables and fruits, have attracted a great interest because of their lack of toxicity and potential ability to act as highly effective chemopreventive agents against T2D and obesity [5,6]. The aim of the present review is summarizing the molecular basis of the chemopreventive activity of flavonoids related to insulin signaling during T2D and obesity.…”
Section: Introductionmentioning
confidence: 99%
“…Thus, at present, it is considered that the most efficient approach to prevent or delay T2D and obesity is the reduction of sedentarism and changes in dietary habits. In this regard, flavonoids, which are natural dietary compounds abundant in vegetables and fruits, have attracted a great interest because of their lack of toxicity and potential ability to act as highly effective chemopreventive agents against T2D and obesity [5,6]. The aim of the present review is summarizing the molecular basis of the chemopreventive activity of flavonoids related to insulin signaling during T2D and obesity.…”
Section: Introductionmentioning
confidence: 99%
“…In a high-fat-induced obesity model in C57BL/6 mice, the activation of AMPK significantly reduced liver fat accumulation and prevented diabetes by inhibiting gluconeogenesis. Insulin-sensitive PI3K/AKT signaling affects glucose and lipid homeostasis in the body [20]. The PI3K/AKT pathway is also involved in the defocused low-energy shock wave in activated adipose tissue-derived stem cells [21].…”
Section: Discussionmentioning
confidence: 99%
“…A HFD could directly induce a significant decrease in m-Glut4 protein expression, while Pt-PS supplementation significantly elevated the expression of key proteins in the plasma membrane of skeletal muscle cells. Glut4 translocation is predominantly triggered by PI3K/Akt signaling [36], in which several proteins are involved, including phosphorylated IRS1, PI3K-IRS1 and phosphorylated Akt. Hatem-Vaquero et al reported that obvious peripheral insulin resistance resulted from the inactivation of the PI3K/Akt pathway and the reduction of Glut4 expression in ILK-depleted mice [37].…”
Section: Discussionmentioning
confidence: 99%