Dietary Polyphenols and In Vitro Intestinal Fructose Uptake and Transport: A Systematic Literature Review

Iametti, Stefania; Bonomi, Francesco; Nunzio, Mattia Di

doi:10.3390/ijms232214355

Cited by 9 publications

(7 citation statements)

References 71 publications

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“…Although studies on humans remain the gold standard for evaluating the relationship between nutrients and health, the development of reliable in vitro/ex vivo models allow the investigation of the cellular/molecular mechanisms and represents a first—and undoubtedly necessary—step when investigating the health-promoting properties of food components [ 25 ]. Table 1 summarizes the data published on the effect of DHA supplementation on antioxidant defenses in cultured cells ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Docosahexaenoic Acid as Master Regulator of Cellular Antioxidant Defenses: A Systematic Review

2023

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Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid that benefits the prevention of chronic diseases. Due to its high unsaturation, DHA is vulnerable to free radical oxidation, resulting in several unfavorable effects, including producing hazardous metabolites. However, in vitro and in vivo investigations suggest that the relationship between the chemical structure of DHA and its susceptibility to oxidation may not be as clear-cut as previously thought. Organisms have developed a balanced system of antioxidants to counteract the overproduction of oxidants, and the nuclear factor erythroid 2-related factor 2 (Nrf2) is the key transcription factor identified for transmitting the inducer signal to the antioxidant response element. Thus, DHA might preserve the cellular redox status promoting the transcriptional regulation of cellular antioxidants through Nrf2 activation. Here, we systematically summarize the research on the possible role of DHA in controlling cellular antioxidant enzymes. After the screening process, 43 records were selected and included in this review. Specifically, 29 studies related to the effects of DHA in cell cultures and 15 studies concerned the effects of consumption or treatment with DHA in animal. Despite DHA’s promising and encouraging effects at modulating the cellular antioxidant response in vitro/in vivo, some differences observed among the reviewed studies may be accounted for by the different experimental conditions adopted, including the time of supplementation/treatment, DHA concentration, and cell culture/tissue model. Moreover, this review offers potential molecular explanations for how DHA controls cellular antioxidant defenses, including involvement of transcription factors and the redox signaling pathway.

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Section: Resultsmentioning

confidence: 99%

Docosahexaenoic Acid as Master Regulator of Cellular Antioxidant Defenses: A Systematic Review

2023

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“…Catalyze the proton linking and transport of monocarboxylate across plasma membranes [32,33] GLUT Intestine Glucose is transported along the concentration gradient in a facilitated diffusion manner [34] Pgp (MDR) Kidney, intestine Multidrug resistant protein [35] ATP-Binding Cassette (ABC) Transporter…”

Section: Mct Liver Intestinementioning

confidence: 99%

Role of Transporters in Hyperuricemia

Zhang,

Wang,

Wang

et al. 2024

Physiology

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Hyperuricemia (HUA) is a metabolic disorder characterized by elevated serum uric acid levels exceeding the body’s metabolic limit. In the past two decades, the prevalence of this disease has shown an increasing trend and is becoming more common in younger individuals. As a metabolic disease, hyperuricemia has been found to correlate with cardiovascular diseases, renal diseases, and metabolic syndrome. Various complex metabolic processes are involved in the pathological process in the elevation of uric acid. Transporters are one of the most important families controlling the metabolism of uric acid. The vast majority of cases of hyperuricemia are caused by insufficient uric acid excretion and excessive reabsorption by the kidneys. Therefore, limiting the reabsorption of transport proteins is key to lowering uric acid levels. This chapter will revisit the basic situation of hyperuricemia and summarize the known mechanisms of transport proteins in HUA, as well as the therapeutic approaches developed for these transport proteins.

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“…Interestingly, concentrations of other GLUT transporters like GLUT7, 8, and 12 were not altered by the presence of fructose [ 46 ]. On the other hand, as reviewed in detail by Iametti et al, studies suggest that intestinal fructose uptake may be reduced when polyphenols are concomitantly present [ 47 ]. For instance, it has been shown in in vitro studies employing Caco-2 cells that polyphenols like apigenin and derivatives of apigenin, found for instance in chamomile tea, but also catechins found in green tea, can reduce fructose uptake dose-dependently up to ~70 % [ 48 ].…”

Section: Uptake Of Fructose In Small Intestine and Fructose Metabolismmentioning

confidence: 99%

Fructose: a modulator of intestinal barrier function and hepatic health?

Staltner,

Burger,

Baumann

et al. 2023

Eur J Nutr

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Purpose Consumption of fructose has repeatedly been discussed to be a key factor in the development of health disturbances such as hypertension, diabetes type 2, and non-alcoholic fatty liver disease. Despite intense research efforts, the question if and how high dietary fructose intake interferes with human health has not yet been fully answered. Results Studies suggest that besides its insulin-independent metabolism dietary fructose may also impact intestinal homeostasis and barrier function. Indeed, it has been suggested by the results of human and animal as well as in vitro studies that fructose enriched diets may alter intestinal microbiota composition. Furthermore, studies have also shown that both acute and chronic intake of fructose may lead to an increased formation of nitric oxide and a loss of tight junction proteins in small intestinal tissue. These alterations have been related to an increased translocation of pathogen-associated molecular patterns (PAMPs) like bacterial endotoxin and an induction of dependent signaling cascades in the liver but also other tissues. Conclusion In the present narrative review, results of studies assessing the effects of fructose on intestinal barrier function and their impact on the development of health disturbances with a particular focus on the liver are summarized and discussed.

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Dietary Polyphenols and In Vitro Intestinal Fructose Uptake and Transport: A Systematic Literature Review

Cited by 9 publications

References 71 publications

Docosahexaenoic Acid as Master Regulator of Cellular Antioxidant Defenses: A Systematic Review

Docosahexaenoic Acid as Master Regulator of Cellular Antioxidant Defenses: A Systematic Review

Role of Transporters in Hyperuricemia

Fructose: a modulator of intestinal barrier function and hepatic health?

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