Dietary potential probiotics and enzymes complex modulates the performance and rumen microbiota in weaned goats

Abstract

Aims This trial was performed to investigate the effects of combined feeding of Candida utilis CICC 31170, Bacillus coagulans R11, and Lactobacillus acidophilus NCFM and a multi-enzyme complex on the growth performance, immune parameters, feed digestibility, and rumen microbiota of weaned goats. Methods and Results Thirty weaned goats were randomly divided into CON, PRB, and COB groups and fed different diets. End weight and ADG increased significantly in the PRB and COB groups (P < 0.05), and ADFI increased significantly in COB (P < 0.05). On day 80, there was a significant increase in IL-10 content in PRB and COB compared to the CON (P < 0.05). Highly significant increases in rumen papilla width, epithelial cell thickness, stratum spinosum+basale thickness, and stratum corneum thickness were found in PRB and COB (P < 0.05). COB group significantly increased the gene expression of HMGCL and MCT1 in rumen epithelium (P < 0.001). The COB group had the tendency to increase the feed digestibility of dry matter and crude fat compared with the CON group (P < 0.10). The abundance of Prevotellaceae_unclassified was significantly higher in PRB (P < 0.05), and the abundance of Fibrobacteres was significantly higher in COB in comparison to those in CON (P < 0.05). Conclusions The results indicate that the dietary potential probiotics and enzymes complex could modulate the growth performance, immunity, feed digestibility, and rumen microbiota in weaned goats.

In vitro safety and functional characterization of the novel Bacillus coagulans strain CGI314

“…Bacillus coagulans is a gram-positive, facultative anaerobic, nonpathogenic, endospore-forming, lactic acid-producing bacteria and has been granted Generally Recognized as Safe (GRAS) status by the US Food and Drug Administration (FDA) ( Cao et al, 2020 ). Several studies have demonstrated the beneficial effects of this probiotic species when administered as a feed additive or dietary supplement to livestock, aquaculture and human health ( Hung et al, 2012 ; Gu et al, 2015 ; Izadi et al, 2020 ; Lu et al, 2023 ). In preclinical studies, B. coagulans has demonstrated improved body weight, enhanced average daily gain, improved feed conversion ratio, antioxidant capacity, immunity function and gut health in broiler chickens ( Hung et al, 2012 ; Zhang et al, 2021 ; Cao et al, 2022 ).…”

Effect of the supplementation of exogenous complex non-starch polysaccharidases on the growth performance, rumen fermentation and microflora of fattening sheep

“…Cellulases and xylanases are the most widely used exogenous enzymes in animals and play important roles in nutrient utilization. In addition, enzyme supplementation has a potential effect on the composition and metabolic capacity of rumen microbes ( 18 , 19 ), which can alter the composition of microbial communities ( 20 , 21 ) and improve rumen fermentation and health ( 22 ). In the actual production process, most farmers use a sloppy meat farming model to obtain higher economic benefits.…”

Evaluation of Increasing Dietary Concentrations of a Multi-Enzyme Complex in Feedlot Lambs’ Rations

“…Furthermore, few experiments have evaluated dietary supplementation with phytase [12], protease [13], or glucoamylase [14,15]. It should be noted that there have been studies focusing on the supplementation of enzyme complexes [16,17]. In non-ruminants, M-E preparations are frequently used [18,19], with blends formulated on a ration of indigestible components to obtain more nutrients [20].…”