Dietary protein intake and subsequent falls in older men and women: The Framingham study

Zoltick, Emilie S.; Sahni, Shivani; McLean, Robert R.; Quach, Lien; Casey, Virginia; Hannan, Marian T.

doi:10.1007/s12603-010-0331-3

Cited by 13 publications

(18 citation statements)

References 44 publications

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“…This result is contrary to previous research in large population-based cohorts in older adults (.60 y of age), which showed dietary protein to be positively associated with BMD cross-sectionally (29) with reduced bone loss over time in the Framingham Original Cohort (6) and with reduced risk of falls (30) and fracture in the Framingham Original Cohort (31, 32) longitudinally. Null results in the current study may be explained by the overall young age of the cohort (mean age: 40 y) of whom only 15% of subjects were aged .50 y, which is a time when the age-related loss of bone mass typically becomes evident.…”

Section: Discussioncontrasting

confidence: 99%

Dietary protein is associated with musculoskeletal health independently of dietary pattern: the Framingham Third Generation Study ,

Mangano

Sahni

Kiel

et al. 2017

The American Journal of Clinical Nutrition

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Background: Above-average dietary protein, as a single nutrient, improves musculoskeletal health. Evaluating the link between dietary protein and musculoskeletal health from a whole-diet perspective is important, as dietary guidelines focus on dietary patterns. Objective: We examined the prospective association of novel dietary protein food clusters (derived from established dietary pattern techniques) with appendicular lean mass (ALM), quadriceps strength (QS), and bone mineral density (BMD) in 2986 men and women, aged 19-72 y, from the Framingham Third Generation Study. Design: Total protein intake was estimated by food-frequency questionnaire in [2002][2003][2004][2005]. A cluster analysis was used to classify participants into mutually exclusive groups, which were determined by using the percentage of contribution of food intake to overall protein intake. General linear modeling was used to 1) estimate the association between protein intake (grams per day) and BMD, ALM, appendicular lean mass normalized for height (ALM/ht 2 ), and QS (2008)(2009)(2010)(2011) and to 2) calculate adjusted least-squares mean outcomes across quartiles of protein (grams per day) and protein food clusters. Results: The mean 6 SD age of subjects was 40 6 9 y; 82% of participants met the Recommended Daily Allowance (0.8 g $ kg body weight). The following 6 dietary protein food clusters were identified: fast food and full-fat dairy, fish, red meat, chicken, low-fat milk, and legumes. BMD was not different across quartiles of protein intake (P-trend range = 0.32-0.82); but significant positive trends were observed for ALM, ALM/ht 2 (P , 0.001), and QS (P = 0.0028). Individuals in the lowest quartile of total protein intake (quartile 1) had significantly lower ALM, ALM/ht 2 , and QS than did those in the higher quartiles of intake (quartiles 2-4; (P ranges = 0.0001-0.003, 0.0007-0.003, and 0.009-0.05, respectively). However, there were no associations between protein clusters and any musculoskeletal outcome in adjusted models. Conclusions: In a protein-replete cohort of adults, dietary protein is associated with ALM and QS but not with BMD. In this study, dietary protein food patterns do not provide further insight into beneficial protein effects on muscle outcomes.Am J Clin Nutr 2017;105:714-22.

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Section: Discussioncontrasting

confidence: 99%

Dietary protein is associated with musculoskeletal health independently of dietary pattern: the Framingham Third Generation Study ,

Mangano

Sahni

Kiel

et al. 2017

The American Journal of Clinical Nutrition

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“…Overall ROB for these studies was low, although it is important to note that it is unclear if there was enough statistical power to detect an association with continuous protein intake data in either study (Supplemental Table 5). One study (49) found higher protein intake to be associated with a lower risk of falls compared with lower protein intake, whereas the other study (48) found no significant association (Supplemental Table 10). …”

Section: Cohort Studiesmentioning

confidence: 99%

“…Two cohort studies in older adults examined the risk of falls over a 1-to 2-y period (Supplemental Table 8) (48,49). Protein intake was assessed by using an FFQ.…”

Section: Cohort Studiesmentioning

confidence: 99%

Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation,

Shams-White

Chung²,

et al. 2017

The American Journal of Clinical Nutrition

199

128

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Background: Considerable attention has recently focused on dietary protein's role in the mature skeleton, prompted partly by an interest in nonpharmacologic approaches to maintain skeletal health in adult life. Objective: The aim was to conduct a systematic review and metaanalysis evaluating the effects of dietary protein intake alone and with calcium with or without vitamin D (Ca6D) on bone health measures in adults. Design: Searches across 5 databases were conducted through October 2016 including randomized controlled trials (RCTs) and prospective cohort studies examining 1) the effects of "high versus low" protein intake or 2) dietary protein's synergistic effect with Ca6D intake on bone health outcomes. Two investigators independently conducted abstract and full-text screenings, data extractions, and risk of bias (ROB) assessments. Strength of evidence was rated by group consensus. Random-effects meta-analyses for outcomes with $4 RCTs were performed. Results: Sixteen RCTs and 20 prospective cohort studies were included in the systematic review. Overall ROB was medium. Moderate evidence suggested that higher protein intake may have a protective effect on lumbar spine (LS) bone mineral density (BMD) compared with lower protein intake (net percentage change: 0.52%; 95% CI: 0.06%, 0.97%, I2 : 0%; n = 5) but no effect on total hip (TH), femoral neck (FN), or total body BMD or bone biomarkers. Limited evidence did not support an effect of protein with Ca6D on LS BMD, TH BMD, or forearm fractures; there was insufficient evidence for FN BMD and overall fractures. Conclusions: Current evidence shows no adverse effects of higher protein intakes. Although there were positive trends on BMD at most bone sites, only the LS showed moderate evidence to support benefits of higher protein intake. Studies were heterogeneous, and confounding could not be excluded. High-quality, long-term studies are needed to clarify dietary protein's role in bone health. This trial was registered at www.crd.york.ac.uk as CRD42015017751.Am J Clin Nutr 2017;105:1528-43.

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“…[22] Sarcopenia increases the risk for falls as well as fractures in older adults. [23] In a study of over 1,600 men and women aged 55-98 years, men with sarcopenia were two times as likely to have fallen in the past year versus those without sarcopenia. [24] Another study of 2,148 older adults aged 59-73 years also reported that falls were inversely related to muscle strength in men and women.…”

Section: Decreased Physical Functionmentioning

confidence: 99%

Sarcopenia-A baby boomers dilemma for nurse practitioners to discover, diagnose, and treat

Jackson

Hunt²,

Chapa³

et al. 2018

JNEP

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Objective: Sarcopenia is a disease of low skeletal muscle mass and strength that occurs with aging. It is most commonly seen in individuals aged 50 years and over. Nurse practitioners can take a proactive approach to the understanding and screening of this disease in attempts to prolong its onset or to treat the condition before it leads to additional adverse consequences. Methods: A comprehensive review of the literature, including evidence-based literature from peer-reviewed articles, including randomized controlled trials, was conducted.Results: This review of the literature indicated patients can benefit greatly from nurse practitioner's awareness and intervention by screening for sarcopenia as well as offering appropriate education and treatment to their patients. Once a diagnosis is reached, the nurse practitioner can then collaborate with other disciplines such as nutrition, medicine, exercise physiology and/or physical therapy to develop an intervention strategy that can treat or prevent this condition before it leads to decreased independence, early onset disability and decreased quality of life, among other adverse health outcomes. Conclusions: There is a call to action on the part of nurse practitioners in efforts to prevent and/or slow the onset of age-related sarcopenia and its adverse consequences.

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Dietary protein intake and subsequent falls in older men and women: The Framingham study

Cited by 13 publications

References 44 publications

Dietary protein is associated with musculoskeletal health independently of dietary pattern: the Framingham Third Generation Study ,

Dietary protein is associated with musculoskeletal health independently of dietary pattern: the Framingham Third Generation Study ,

Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation,

Sarcopenia-A baby boomers dilemma for nurse practitioners to discover, diagnose, and treat

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