Dietary protein restriction and excess of pregnant German Landrace sows induce changes in hepatic gene expression and promoter methylation of key metabolic genes in the offspring

Altmann, Simone; Muráni, Eduard; Schwerin, Manfred; Metges, C. C.; Wimmers, Klaus; Ponsuksili, Siriluck

doi:10.1016/j.jnutbio.2012.01.011

Cited by 36 publications

(23 citation statements)

References 97 publications

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“…This view is supported by major abundance of exon 1A in cells related to the hematopoietic system observed in humans (Breslin et al, 2001). Several studies demonstrated that hepatic expression of NR3C1 in the pig is modulated by genetic and epigenetic factors (Altmann et al, 2012;Zou et al, 2012). These may act on the promoter of exon 1A, given the high proportion and preferential expression of exon 1A in liver.…”

Section: Discussionmentioning

confidence: 94%

Transcript variants of the porcine glucocorticoid receptor gene (NR3C1)

Reyer¹,

Ponsuksili²,

Wimmers³

et al. 2013

General and Comparative Endocrinology

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Section: Discussionmentioning

confidence: 94%

Transcript variants of the porcine glucocorticoid receptor gene (NR3C1)

Reyer¹,

Ponsuksili²,

Wimmers³

et al. 2013

General and Comparative Endocrinology

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“…Dolinoy et al (10) found that in utero exposure to dietary genistein, the major phytoestrogen in soy, modified coat color in mice by inducing methylation of CpG sites in a retrotransposon upstream of the transcriptional start site of the Agouti gene responsible for coat color. Similarly, high protein or proteinrestricted diets fed to sows affected DNA methylation of individual CpG sites in a number of metabolic genes in offspring compared with controls (11). Adult diet has also been shown to affect the DNA methylation patterning in a variety of tissues.…”

Section: Environmental Influences On Dna Methylationmentioning

confidence: 97%

Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression

Buro-Auriemma

Salit

Hackett

et al. 2013

Human Molecular Genetics

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The small airway epithelium (SAE), the first site of smoking-induced lung pathology, exhibits genome-wide changes in gene expression in response to cigarette smoking. Based on the increasing evidence that the epigenome can respond to external stimuli in a rapid manner, we assessed the SAE of smokers for genome-wide DNA methylation changes compared with nonsmokers, and whether changes in SAE DNA methylation were linked to the transcriptional output of these cells. Using genome-wide methylation analysis of SAE DNA of nonsmokers and smokers, the data identified 204 unique genes differentially methylated in SAE DNA of smokers compared with nonsmokers, with 67% of the regions with differential methylation occurring within 2 kb of the transcriptional start site. Among the genes with differential methylation were those related to metabolism, transcription, signal transduction and transport. For the differentially methylated genes, 35 exhibited a correlation with gene expression, 54% with an inverse correlation of DNA methylation with gene expression and 46% a direct correlation. These observations provide evidence that cigarette smoking alters the DNA methylation patterning of the SAE and that, for some genes, these changes are associated with the smoking-related changes in gene expression.

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“…Other responsible molecular mechanisms need to be further determined. In German Landrace sows, it was observed that maternal dietary protein supplement or restriction altered DNA methylation of offspring key metabolic genes, which may lead to the long-term alteration in metabolic consequences (Altmann et al, 2013).…”

Section: Malementioning

confidence: 99%