Dietary protein sources and tumoral overexpression of RhoA, VEGF-A and VEGFR2 genes among breast cancer patients

Shokri, Ali; Pirouzpanah, Saeed; Foroutan-Ghaznavi, Mitra; Montazeri, Vahid; Fakhrjou, Ashraf; Charoudeh, Hojjatollah Nozad; Tavoosidana, Gholamreza

doi:10.1186/s12263-019-0645-7

Cited by 10 publications

(6 citation statements)

References 56 publications

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“…Although the pattern was not unilaterally associated with blood pressure measurements in our team's previous analyses [19], and an increased predisposition to higher VEGF-A appears to bring its aggravating effect to the forefront and vice versa. This could be partly attributed to the positive effect of the Western diet and red meat-derived protein, which has been previously shown to elevate VEGF-A expression among patients with breast cancer [43].…”

Section: Discussionmentioning

confidence: 93%

Associations of VEGF-A-Related Variants with Adolescent Cardiometabolic and Dietary Parameters

et al. 2023

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Previous research has allowed the identification of variants related to the vascular endothelial growth factor-A (VEGF-A) and their association with anthropometric, lipidemic and glycemic indices. The present study examined potential relations between key VEGF-A-related single-nucleotide polymorphisms (SNPs), cardiometabolic parameters and dietary habits in an adolescent cohort. Cross-sectional analyses were conducted using baseline data from 766 participants of the Greek TEENAGE study. Eleven VEGF-A-related SNPs were examined for associations with cardiometabolic indices through multivariate linear regressions after adjusting for confounding factors. A 9-SNP unweighted genetic risk score (uGRS) for increased VEGF-A levels was constructed to examine associations and the effect of its interactions with previously extracted dietary patterns for the cohort. Two variants (rs4416670, rs7043199) displayed significant associations (p-values < 0.005) with the logarithms of systolic and diastolic blood pressure (logSBP and logDBP). The uGRS was significantly associated with higher values of the logarithm of Body Mass Index (logBMI) and logSBP (p-values < 0.05). Interactions between the uGRS and specific dietary patterns were related to higher logDBP and logGlucose (p-values < 0.01). The present analyses constitute the first-ever attempt to investigate the influence of VEGF-A-related variants on teenage cardiometabolic determinants, unveiling several associations and the modifying effect of diet.

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Section: Discussionmentioning

confidence: 93%

Associations of VEGF-A-Related Variants with Adolescent Cardiometabolic and Dietary Parameters

et al. 2023

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“…Also, Taha et al hypothesized that a diet with high casein might increase the progression of cancer cells in mice through the activation of the IGF/Akt/mTOR pathway [55]. Also, it seems proteins from animal sources throughout increased insulin-like growth factor-1 [56], and the expression of Ras homologous gene family member A and vascular endothelial growth factor receptor-2 [57] lead to tumor progression. However, plant protein intake was inversely associated with RhoA expression [57].…”

Section: Discussionmentioning

confidence: 99%

High-protein diet scores, macronutrient substitution, and breast cancer risk: insights from substitution analysis

Jahromi,

Ahmadirad,

Farhadnejad

et al. 2024

BMC Women's Health

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Background Evidence from recent studies suggested that variation in the quantity and quality of macronutrients in the diet may potentially play a role in predicting the risk of breast cancer (BC). In the current study, we aimed to assess the association of different high-protein diet scores and replacing fats and carbohydrate (CHO) with protein in the diet with the BC risk among Iranian women. Methods The current hospital-based case-control study was conducted on 401 participants, aged ≥ 30 years old, including 134 women in the case group who had been diagnosed with histologically confirmed BC and 267 women in the control group. Dietary intake data was collected using a validated food frequency questionnaire, and high protein diet scores were determined. Logistic regression models were used to determine the odds ratios (OR) and 95% confidence interval (CI) of BC across tertiles of high protein diet scores. Also, we assessed how substituting protein with other macronutrients affected BC odds while adjusting for the various confounding variables. Results Participants’ mean ± SD of age and body mass index were 47.9 ± 10.3 years and 29.4 ± 5.5 kg/m2, respectively. The scores of high-protein-low-CHO and fat diet, high-protein and CHO-low-fat diet, and high-protein and fat-low-CHO diet in participants were 16.5 ± 3.8, 16.5 ± 6.7, and 16.4 ± 5.9, respectively. In the multivariable model, individuals in the highest tertile of high-protein-low-CHO and fat diet score (OR:0.71;95%CI:0.56–0.90) and high-protein and CHO-low-fat diet (OR:0.76;95%CI:0.60–0.97) had lower odds of BC compared to those in the lowest tertile (P < 0.05). However, no significant association was found between high-protein and fat-low-CHO diet and BC risk. Our results showed that replacing fat by protein (ORdifferences:-0.40;95%CI:-0.73,-0.07) and also replacing refined-CHO by plant protein (ORdifferences:-0.66;95%CI:-1.26,-0.07) in the diet are associated inversely with risk of BC(P < 0.05). Conclusions The results of our study suggested that higher adherence to a high-protein-low-CHO and fat diet, characterized by a higher intake of plant proteins and a lower intake of refined grains and saturated fat can play a protective role against the odds of BC.

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“…Since the vasculature is essential for adipose tissue expansion, as it supplies oxygen and nutrients and is also responsible for the transport of fatty acids to other tissues, angiogenesis is considered to be a rate-limiting step in fat tissue expansion ( 102 ). VEGF-A levels are regulated by both external factors, such as exercise ( 103 ) and dietary protein levels ( 104 ), and internal factors, such as hypoxia and various growth factors ( 105 , 106 ). Adipocytes store lipids in lipid droplets when nutrients are abundant, and as they increase in size, oxygen becomes less available, which leads to a hypoxic status.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of perirenal fat from Spanish Assaf suckling lamb carcasses showing different levels of kidney knob and channel fat

et al. 2023

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IntroductionSuckling lamb meat is highly appreciated in European Mediterranean countries because of its mild flavor and soft texture. In suckling lamb carcasses, perirenal and pelvic fat depots account for a large fraction of carcass fat accumulation, and their proportions are used as an indicator of carcass quality.Material and MethodsThis study aimed to characterize the genetic mechanisms that regulate fat deposition in suckling lambs by evaluating the transcriptomic differences between Spanish Assaf lambs with significantly different proportions of kidney knob and channel fat (KKCF) depots in their carcasses (4 High-KKCF lambs vs. 4 Low-KKCF lambs).ResultsThe analyzed fat tissue showed overall dominant expression of white adipose tissue gene markers, although due to the young age of the animals (17–36 days), the expression of some brown adipose tissue gene markers (e.g., UCP1, CIDEA) was still identified. The transcriptomic comparison between the High-KKCF and Low-KKCF groups revealed a total of 80 differentially expressed genes (DEGs). The enrichment analysis of the 49 DEGs with increased expression levels in the Low-KKCF lambs identified significant terms linked to the biosynthesis of lipids and thermogenesis, which may be related to the higher expression of the UCP1 gene in this group. In contrast, the enrichment analysis of the 31 DEGs with increased expression in the High-KKCF lambs highlighted angiogenesis as a key biological process supported by the higher expression of some genes, such as VEGF-A and THBS1, which encode a major angiogenic factor and a large adhesive extracellular matrix glycoprotein, respectively.DiscussionThe increased expression of sestrins, which are negative regulators of the mTOR complex, suggests that the preadipocyte differentiation stage is being inhibited in the High-KKCF group in favor of adipose tissue expansion, in which vasculogenesis is an essential process. All of these results suggest that the fat depots of the High-KKCF animals are in a later stage of development than those of the Low-KKCF lambs. Further genomic studies based on larger sample sizes and complementary analyses, such as the identification of polymorphisms in the DEGs, should be designed to confirm these results and achieve a deeper understanding of the genetic mechanisms underlying fat deposition in suckling lambs.

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Dietary protein sources and tumoral overexpression of RhoA, VEGF-A and VEGFR2 genes among breast cancer patients

Cited by 10 publications

References 56 publications

Associations of VEGF-A-Related Variants with Adolescent Cardiometabolic and Dietary Parameters

Associations of VEGF-A-Related Variants with Adolescent Cardiometabolic and Dietary Parameters

High-protein diet scores, macronutrient substitution, and breast cancer risk: insights from substitution analysis

Transcriptome analysis of perirenal fat from Spanish Assaf suckling lamb carcasses showing different levels of kidney knob and channel fat

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