Dietary pterostilbene exerts potential protective effects by regulating lipid metabolism and enhancing antioxidant capacity on liver in broilers

Zhang, Licong; Zhang, Jingyang; Zang, Haoran; Yin, Zesheng; Guan, Peiyue; Yu, Chunting; Shan, Anshan; Feng, Xingjun

doi:10.1111/jpn.13941

Cited by 14 publications

(5 citation statements)

References 50 publications

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“…These findings suggest that HE, OE, and ZE had a hepatoprotective potential against AFB1-induced oxidative stress and its associated pathogenesis. These results align with the well-established role of natural plant products in treating and preventing chronic diseases, including liver disorders [61][62][63]. In particular, Z. multiflora, O. dhofarense, and H. bacciferum have a wide medicinal application [64].…”

Section: Discussionsupporting

confidence: 81%

Aflatoxin B1 Detoxification and Antioxidant Effect of Selected Omani Medicinal Plants against Aflatoxin B1-Induced Oxidative Stress Pathogenesis in the Mouse Liver

Velazhahan,

Al-Sadi,

Waly

et al. 2024

Applied Sciences

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This study investigated the ability of aqueous leaf extracts of Heliotropium bacciferum (HE), Ocimum dhofarense (OE), and Zataria multiflora (ZE) to detoxify aflatoxin B1 (AFB1) under in vitro and in vivo conditions. The results showed that HE, OE, and ZE degraded 95%, 93%, and 92% of AFB1, respectively, after 72 h incubation at 37 °C. The degradation of AFB1 was validated by liquid chromatography–mass spectrometry analysis. A molecular ion peak at m/z 313 specific to AFB1 (C17H12O6) was observed in the mass spectrum of untreated AFB1 (control). However, the level of AFB1 was decreased to untraceable levels in response to treatment with these plant extracts. HE, OE, and ZE effectively detoxified AFB1 in a concentration-dependent manner, resulting in mortality rates of 65, 70, and 75% of brine shrimp, respectively, in contrast to 90% in the untreated AFB1 (control). The hepatoprotective effect of HE, OE, and ZE against AFB1-induced oxidative stress pathogenesis was investigated using mice as an experimental model. Glutathione depletion, impairment of total antioxidant capacity, and increase in DNA oxidative damage were observed in liver tissues of mice treated with AFB1. However, HE, OE, and ZE extract supplementation suppressed the oxidative damage associated with AFB1 treatment. Our findings indicated that HE, OE, and ZE were highly effective in the detoxification of AFB1. In addition, HE, OE, and ZE act as potent antioxidants and combat the AFB1-associated oxidative stress and liver pathogenesis, suggesting that these plants might be valuable for the development of functional foods aimed at minimizing the toxic effects of AFB1.

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Section: Discussionsupporting

confidence: 81%

Aflatoxin B1 Detoxification and Antioxidant Effect of Selected Omani Medicinal Plants against Aflatoxin B1-Induced Oxidative Stress Pathogenesis in the Mouse Liver

Velazhahan,

Al-Sadi,

Waly

et al. 2024

Applied Sciences

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“…Almost all phenols can act as lipid peroxidation antioxidants because they scavenge the chain-carrying lipid peroxyl radicals [76,77]. Rudrapal et al [78] mentioned some phenolic compounds that act against the accumulation of lipid peroxidation products including quercetin, which we found in our extracts.…”

Section: -Determination Of Tissue Proteinsmentioning

confidence: 52%

Antioxidant Activity and Effectiveness of Fig Extract in Counteracting Carbon Tetrachloride-Induced Oxidative Damage in Rats

Kebal,

Djebli,

Pokajewicz

et al. 2024

Molecules

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Figs are the edible fruits of the fig tree, Ficus carica L., that have been used for centuries for human consumption and in traditional medicine, to treat skin problems, inflammation, and gastrointestinal disorders. Our previous study investigated the presence of phenolic compounds in aqueous extracts of two Algerian popular fig varieties, azendjar (Az) and taamriouth (Ta), as well as their in vitro antioxidant activity. In this study, we assessed hydroethanolic extracts of these fig varieties. The total phenolic content was measured, along with the phenolic profile. Rutin was determined to be the dominant phenolic compound, followed by vanillic acid, 3,4-dihydroxybenzoic acid, quercetin, 4-hydroxybenzoic acid, rosmarinic acid (in Az only), and cinnamic acid. The antioxidant activity of the extracts was evaluated both in vitro (DPPH and FRAP assays) and in vivo, in rats intoxicated with carbon tetrachloride. In all assays, the fig extract—especially the dark-peeled fig variety azendjar—showed antioxidant potency. The administration of fig extract resulted in a reduction in liver damage, expressed by both different biochemical markers and histopathological study (less degraded liver architecture, reduced fibrosis, and only mild inflammation). A dose-dependent therapeutic effect was observed. The extract from the dark-peeled fig variety, Az, was characterized by a higher phenolic content and a stronger antioxidant activity than the extract from the light-peeled variety—Ta. Our study justifies the use of figs in traditional healing and shows the potential of using fig extracts in natural medicines and functional foods.

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“…Previous studies have demonstrated the attractive preventive and therapeutic properties of PTE in a range of inflammation-related diseases [27][28][29][30]. Our previous research showed that compared with the control group, PTE supplementation increased final body weight (FBW), with significant improvements observed in the PTE 200 and PTE 400 groups, the PTE 200 , PTE 400 , and PTE 600 groups showed significant increases in average daily gain (ADG) [31]. However, the role of PTE in improving organism immunity and intestinal health in broilers remains unclear.…”

Section: Discussionmentioning

confidence: 98%

The Effects of Dietary Pterostilbene on the Immune Response, Antioxidant Function, and Jejunal Structure of Broilers

Yin,

Sun,

Chai

et al. 2024

Animals

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This experiment was carried out to investigate the effect of pterostilbene (PTE) supplementation in feed on Arbor Acres broilers in terms of serum biochemical parameters, immune and inflammatory responses, antioxidant status, and intestinal morphological structure. For a duration of 42 days, a total of 480 1-day-old Arbor Acres broilers were randomly divided into four groups. Each group was assigned to receive either the basal diet or the basal diet supplemented with 200, 400, or 600 mg/kg of PTE. Each treatment consisted of eight replicates, with 15 chicks per replicate. In comparison with the control group, three PTE treatments significantly increased the lymphocyte transformation rate in the spleen of broilers. The automated biochemical analysis, enzyme-linked immunosorbent assay, and RT-qPCR analysis kits found that 400 mg/kg of PTE significantly increased the serum levels of complement C3, IL-4, and iNOS; reduced the serum levels of IL-6, TNF-α, and mRNA levels of the genes IL-6, IL-8, TNF-α, NLRP3, and IFN-γ; significantly improved the activities of antioxidant enzymes including CAT, GSH-Px, and T-SOD in the jejunum; and significantly reduced the MDA contents in the serum and jejunum of broilers. Nikon microscope observations and ImagePro Plus 6.0 measure results found that 400 mg/kg of PTE supplementation significantly reduced the relative length and weight of the jejunum and improved the jejunal villi structure, resulting in increased intestinal villi, deepened crypt, and an enhanced ratio of villi height to crypt depth (VH/CD). RT-qPCR and Western blot found that dietary PTE also resulted in increased mRNA levels of the genes Claudin-2, Occludin, ZO-1, and Sirt1, and decreased NF-κB protein levels in the jejunum. The results of this study demonstrated that dietary PTE improved the immune function and intestinal health of broilers by reducing inflammation and increasing the antioxidant capacity of the animals.

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Dietary pterostilbene exerts potential protective effects by regulating lipid metabolism and enhancing antioxidant capacity on liver in broilers

Cited by 14 publications

References 50 publications

Aflatoxin B1 Detoxification and Antioxidant Effect of Selected Omani Medicinal Plants against Aflatoxin B1-Induced Oxidative Stress Pathogenesis in the Mouse Liver

Aflatoxin B1 Detoxification and Antioxidant Effect of Selected Omani Medicinal Plants against Aflatoxin B1-Induced Oxidative Stress Pathogenesis in the Mouse Liver

Antioxidant Activity and Effectiveness of Fig Extract in Counteracting Carbon Tetrachloride-Induced Oxidative Damage in Rats

The Effects of Dietary Pterostilbene on the Immune Response, Antioxidant Function, and Jejunal Structure of Broilers

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