Dietary Regulation of Transketolase Activity in Liver

Cheng, Chuan Huan; Koch, Mary B.; Shank, Robert E.

doi:10.1093/jn/98.1.64

Cited by 9 publications

(1 citation statement)

References 24 publications

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“…These methods are, however, of limited value since urinary excretion reflects only recent dietary intake and both methods are neither sensi tive enough nor specific in the evaluation of a marginal deficiency of this vitamin [Dewhurst and Morgan, 1970;Thompson, 1967;Zbinden, 1962;Bhuvaneswaran and Screenivasen, 1962;Ziporin et al, 1965]. Because of these limitations, measurements of the en zyme transketolase in red cell hemolysate [Basu et al, 1974] and in leukocytes [Cheng et al, 1969] have been reported to be more sensitive and specific than other methods in determining thiamine status.…”

Section: Introductionmentioning

confidence: 99%

Transketolase Activities and Body Weight Changes in Rats on Low Protein Diets

Si¹

1984

Ann Nutr Metab

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Transketolase activity was studied in rats fed a peasant diet containing 5.9% protein, carbohydrate diets (sucrose, glucose, lactose and starch, each containing 5.0% protein) and a normal diet which contained 21 % protein. The activity of the enzyme in red cell hemolysate was independent of the protein content of these diets. However, rats fed a low protein diet had significantly higher hepatic transketolase activity than those fed the normal diet. The hepatic transketolase activity was highest in rats fed a diet containing 4 mg thiamine/kg diet. Further dietary increase in the levels of this vitamin did not cause any further increase in the level of activity of the enzyme, thus suggesting that excess dietary thiamine may have a minimal effect on the activity of this enzyme.

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