Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women

Mackinnon, Erin S.; Rao, A.V.; Rao, L.G.

doi:10.1007/s12603-011-0026-4

Cited by 55 publications

(35 citation statements)

References 37 publications

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“…Rao et al (36) reported lycopene is a carotenoid commonly found in tomatoes and tomato products that acts as an antioxidant to decrease oxidative stress and the levels of bone turnover markers in postmenopausal women. Furthermore, dietary restriction of lycopene for a period of 1 mo resulted in significantly increased biomarkers of oxidative E513 SYMPATHETIC REGULATION OF OSTEOCLASTOGENESIS stress and bone resorption in postmenopausal women (30). We also demonstrated ␣-LA treatment suppressed isoproterenolincreased bone resorption.…”

Section: Discussionmentioning

confidence: 54%

β-Adrenergic signaling stimulates osteoclastogenesis via reactive oxygen species

Kondo

Takeuchi

Togari

2013

American Journal of Physiology-Endocrinology and Metabolism

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Sympathetic signaling regulates bone resorption through receptor activator of nuclear factor-B ligand (RANKL) expression via the ␤-adrenergic receptor (␤-AR) on osteoblasts. Reactive oxygen species (ROS) are known as one type of osteoclast regulatory molecule. Here we show that an antioxidant, ␣-lipoic acid (␣-LA), treatment prevent the ␤-adrenergic signaling-induced bone loss by suppressing osteoclastogenesis, and sympathetic signaling directly regulates osteoclastogenesis through ␤2-AR expressed on osteoclasts via intracellular ROS generation. In an in vitro study, the ␤-AR agonist isoprenaline increased intracellular ROS generation in osteoclasts prepared from bone marrow macrophages (BBMs) and RAW 264.7 cells. Isoprenaline enhanced osteoclastogenesis through ␤2-AR expressed on BMMs and RAW 264.7 cells. The antioxidant ␣-LA inhibited isoprenaline-enhanced osteoclastogenesis. Isoprenaline increased the expression of osteoclastrelated genes such as nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 1, tartrate-resistant acid phosphatase, and cathepsin K on osteoclasts. ␣-LA also inhibited isoprenaline-induced increases of these gene expressions. These in vitro results led to the hypothesis that ␤-adrenergic signaling directly stimulates osteoclastogenesis via ROS generation. In an in vivo study, isoprenaline treatment alone caused oxidative damage in local bone and reduced bone mass because of an increase in bone resorption, and, in ␣-LAtreated mice, isoprenaline did not increase tibial osteoclast number even though the RANKL-to-osteoprotegerin ratio increased. These in vitro and in vivo results indicate that ␤-adrenergic signaling, at least in part, directly stimulates osteoclastogenesis through ␤2-AR on osteoclasts via ROS generation.␤-adrenergic receptor; bone metabolism; osteoclast THE SYMPATHETIC NERVOUS SYSTEM has been shown to be involved in the regulation of bone remodeling (3,

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Section: Discussionmentioning

confidence: 54%

β-Adrenergic signaling stimulates osteoclastogenesis via reactive oxygen species

Kondo

Takeuchi

Togari

2013

American Journal of Physiology-Endocrinology and Metabolism

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“…Otros posibles efectos beneficiosos atribuidos al licopeno han sido la inhibición de la actividad transcripcional de estrógenos (mecanismo que reduce la carcinogénesis) 21 , una asociación inversa entre el contenido de licopeno en plasma y el Índice de Masa Corporal (IMC) 38 , la protección contra la sarcopenia 39 , efecto antiinflamatorio 40 , protección de la piel frente a daños de la radiación solar 41 , y la posible reducción del riesgo de osteoporosis 42 .…”

Section: Licopenounclassified

El tomate, ¿alimento saludable y/o funcional?

Navarro‐González

Periago

2016

Rev Esp Nutr Hum Diet

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Este trabajo es una revisión bibliográfica científica sobre la presencia de compuestos bioactivos en tomate y derivados y la función de estos compuestos para promover la salud del organismo humano. Diferentes estudios científicos muestran que el tomate o sus derivados tienen diferentes tipos de moléculas, algunas con actividad antioxidante, que actúan protegiendo a lípidos, lipoproteínas, ADN, etc. de los radicales libres generados por el organismo. Esta función podría ser una de las causantes de la aparente relación entre su consumo y la protección de enfermedades degenerativas y crónicas como el cáncer, enfermedades cardiovasculares, enfermedad de Parkinson, etc. Estudios más recientes han propuesto otros mecanismos bioquímicos por los cuales los componentes del tomate pueden ejercer esa función beneficiosa sobre la salud. Pero además de intentar conocer los efectos beneficiosos de los compuestos presentes en el tomate de forma aislada, algunos estudios científicos parecen indicar que el mayor beneficio de este alimento se debe al efecto sinérgico que existe entre todos sus compuestos. Y algunos estudios epidemiológicos asocian que su consumo asiduo tiene diferentes efectos beneficiosos sobre la salud. Debido a la relación existente entre los compuestos bioactivos del tomate, su consumo cotidiano y su efecto sobre la salud humana, el objetivo de la presente revisión bibliográfica es dar a conocer los compuestos presentes en este alimento y sus posibles acciones sobre la salud. PALABRAS CLAVE R E S U M E NEl tomate, ¿alimento saludable y/o funcional?

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“…A shorter study showed no effect at the same retinyl palmitate dose 54 . Mackinnon et al found that in healthy postmenopausal women, dietary lycopene restriction for one month resulted in decreased lutein/zeaxanthin and α-and β-carotene, with significantly increased N-telopeptides, with no effect on bone formation markers 55 .…”

Section: Bonementioning

confidence: 99%

“…where vitamin C intake in postmenopausal women was stratified by calcium intake, it was found that all the increase in BMd was clustered among those with calcium intake >500mg/d while there was no association between vitamin C intake and BMd where calcium intake was lower 58 . leveille et al found that food-derived vitamin C was not associated with BMd in postmenopausal women but supplements for women aged [55][56][57][58][59][60][61][62][63][64] , but not older, used for ≥10 years showed a significantly higher BMD 68 .…”

Section: Calcificationmentioning

confidence: 99%

Cardiovascular calcification and bone: a comparison of the effects of dietary and serum antioxidants

Nicoll¹,

Howard²,

Henein³

2015

ICFJ

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<p>Severe cardiovascular (CV) calcification can manifest as fully formed bone and is regularly found with osteoporosis; both have been shown to be associated with oxidative stress. Studies of the effect of antioxidants on CV calcification are few, but show that deficiency can induce both CV calcification and bone loss, while in conditions of oxidative stress such as renal failure, diabetes and smoking or in osteoporosis and fracture, antioxidants can reduce CV calcification and improve bone. The benefit of antioxidants in healthy adults is less clear and some may be detrimental. Higher intake of <em>α</em>-tocopherol (105.5mg/d vs 76.4mg/d) and β-cryptoxanthin may increase risk of CV calcification while high intake of retinol (≥3000mcg/d) may increase hip fracture risk, although possibly only with vitamin D intake ≤440IU/d; the carotenoids lycopene and β-carotene, however, appear beneficial in bone. Vitamin C shows little effect on CV calcification, although longer term supplementation may improve bone mineral density where calcium intake is >500mg/d. Potential reasons for this include a U-shaped dose/response curve for the fat-soluble antioxidants vitamins A and E (with peak bone mass achieved with retinol intake of 600–840 mcg/d), a failure to measure baseline concentrations so that the response cannot be stratified by requirement, the need to be replete in calcium and vitamin D and supplementation of the wrong isomer of vitamin E. Finally, although little studied, tocotrienols, tocopherols (with the exception of α-tocopherol), resveratrol, epigallocatechin gallate, quercetin, α-lipoic acid and N-acetylcysteine may be effective in both the CV system and bone. </p>

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Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women

Abstract: These findings suggest that the daily consumption of lycopene may be important as it acts as an antioxidant to decrease bone resorption in postmenopausal women and may therefore be beneficial in reducing the risk of osteoporosis.

Cited by 55 publications

References 37 publications

β-Adrenergic signaling stimulates osteoclastogenesis via reactive oxygen species

β-Adrenergic signaling stimulates osteoclastogenesis via reactive oxygen species

El tomate, ¿alimento saludable y/o funcional?

Cardiovascular calcification and bone: a comparison of the effects of dietary and serum antioxidants

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