Dietary restriction protects against chronic-ethanol-induced changes in exploratory behavior in Wistar rats

Pinto, Lucas; Gualberto, Felipe Augusto Souza; Pereira, Simone Cardoso Lisboa; Barros, Paula A.; Franco, G. A. P.; Ribeiro, Ângela Maria

doi:10.1016/j.brainres.2005.12.092

Cited by 8 publications

(6 citation statements)

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“…In this line of reasoning, it has been suggested that the attempt to refrain from eating, which is typical in both underweight and overweight subjects, increases the risk of compensatory substance use, which in turn may influence food intake [20]. Accordingly, animal studies have shown increased self-administration of ethanol, alcohol and cocaine under conditions of food deprivation [24]–[26], and human studies have shown positive associations between the severity of dieting and the prevalence of alcohol, cigarette, and drug use both in overeaters and in at-risk-dieters [27].…”

Section: Discussionmentioning

confidence: 99%

The Association between Overweight and Illegal Drug Consumption in Adolescents: Is There an Underlying Influence of the Sociocultural Environment?

et al. 2011

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BackgroundThe aims of the study were to: a) Examine the distribution of gender-stratified body mass index (BMI), eating attitudes and use of addictive substances, under the hypothesis of a confluent prevalence of weight abnormalities, eating disorders and substance abuse. b) Demonstrate the extent to which family, peer-related and psychosocial factors are common elements in categories of compulsive behaviour.Methodology/Principal FindingsIn the present cross-sectional study, data were collected through self reported questionnaires administered to a large sample of 33,185 15–19 years old adolescents (ESPAD®Italia), divided into weight categories based on the BMI percentile distribution. Multinomial analyses were adopted to address the influence of social, family, leisure time factors, Eating Attitude Test (EAT26) on the association between weight categories and drug use.Recent drugs use was more frequent in overweight and underweight adolescents (p<0.05), especially in females. An EAT26 score ≥20 was more common in overweight adolescents. Multinomial analysis abolished the relationship between overweight and the use of most drugs, implicating self-esteem, parents' educational level, and friendships as mediators of the association. Within the overweight category, adolescents reporting recent drug use, showed greater frequency of having drug-abusing friends (∼80%), and severe problems with parents and school (∼30%) compared to overweight adolescents without recent drug use.ConclusionThe frequent association of overweight and substance use and the presence of common underlying social factors, highlights the need for an interdisciplinary approach involving individual-focused treatment models as well as public health, social and environmental changes to reduce food- and substances-related problems.

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Section: Discussionmentioning

confidence: 99%

The Association between Overweight and Illegal Drug Consumption in Adolescents: Is There an Underlying Influence of the Sociocultural Environment?

et al. 2011

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“…Animal models have shown that neural signals relevant to binge eating are comparable with those involved in substance abuse 31 . For example, animal studies have shown increased self‐administration of ethanol, alcohol and cocaine under conditions of food deprivation 32–34 …”

Section: Discussionmentioning

confidence: 99%

“…31 For example, animal studies have shown increased self-administration of ethanol, alcohol and cocaine under conditions of food deprivation. [32][33][34] In humans it is possible that individuals with higher baseline novelty seeking may also become Psychiatry and Clinical Neurosciences 2009; 63: [82][83][84][85][86][87] Substance abuse in eating disorder 85 more vulnerable to substance abuse under conditions of food deprivation such as that seen in AN and BN, be it long-term starvation or the fluctuating availability associated with the binge/starve pattern of BN. Accordingly, there is evidence suggesting that food restriction induces changes in dopaminergic transmission, including hyperresponsiveness to novelty and environmental stimuli that signal opportunity for drive reduction.…”

Section: Discussionmentioning

confidence: 99%

Lifetime substance abuse, family history of alcohol abuse/dependence and novelty seeking in eating disorders: Comparison study of eating disorder subgroups

Krug

Pinheiro

Bulik

et al. 2009

Psychiatry Clin Neurosci

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Aim:To assess lifetime substance abuse, family history of alcohol abuse/dependence, and novelty seeking in three different eating disorder groups (anorexia nervosa-restrictive; anorexia nervosa-binge eating/purging; anorexia nervosa to bulimia nervosa).Method: A total sample of 371 eating disorder patients participated in the current study. Assessment measures included the prevalence of substance abuse and family history of alcohol abuse/dependence as well as the novelty-seeking subscale of the Temperament and Character Inventory-Revised.Results: Significant differences across groups were detected for lifetime substance abuse, with anorexia nervosa-restrictive individuals exhibiting a significant lower prevalence than the anorexia nervosa to bulimia nervosa and anorexia nervosa-binge eating/ purging patients (P < 0.01). For family history of alcohol abuse/dependence the same pattern was observed (P = 0.04). Novelty seeking was associated with substance abuse (P = 0.002), with the anorexia nervosa to bulimia nervosa group exhibiting significantly higher scores on the novelty-seeking scale than the other two groups (P < 0.001). But family history of alcohol abuse/dependence was not related to novelty seeking (P = 0.092). Conclusion:Lifetime substance abuse appears to be more prevalent in anorexia nervosa patients with bulimic features. Higher novelty-seeking scores may be associated with diagnosis cross-over.

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“… 39 This cognitive decline is largely attributable to the ability of ethanol to cross the blood–brain barrier inducing oxidative stress. 40 , 41 Studies have shown that ethanol withdrawal produces cognitive dysfunction by perturbing frontal cortical, striatal and hippocampal functions. 5 , 42 , 43 In the current study, an increase in spontaneous locomotor activity was observed on protocol days 12 and 24 of chronic ethanol administration.…”

Section: Discussionmentioning

confidence: 99%

6-Methoxyflavone and Donepezil Behavioral Plus Neurochemical Correlates in Reversing Chronic Ethanol and Withdrawal Induced Cognitive Impairment

Arif¹,

Rauf²,

Rehman³

et al. 2022

DDDT

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Dietary restriction protects against chronic-ethanol-induced changes in exploratory behavior in Wistar rats

Cited by 8 publications

References 71 publications

The Association between Overweight and Illegal Drug Consumption in Adolescents: Is There an Underlying Influence of the Sociocultural Environment?

The Association between Overweight and Illegal Drug Consumption in Adolescents: Is There an Underlying Influence of the Sociocultural Environment?

Lifetime substance abuse, family history of alcohol abuse/dependence and novelty seeking in eating disorders: Comparison study of eating disorder subgroups

6-Methoxyflavone and Donepezil Behavioral Plus Neurochemical Correlates in Reversing Chronic Ethanol and Withdrawal Induced Cognitive Impairment

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