Dietary restriction suppresses tumor growth, reduces angiogenesis, and improves tumor microenvironment in human non-small-cell lung cancer xenografts

Lin, Baoquan; Zeng, Zhiyong; Yang, Shengsheng; Zhuang, Congwen

doi:10.1016/j.lungcan.2012.11.001

Cited by 19 publications

(18 citation statements)

References 31 publications

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“…Dietary restriction remains one of the most robust methods for lifespan extension and health improvement. Its benefits are widespread, including improved responses in models of cancer (90, 91), neurodegeneration (92), and other age-related disorders (93–95). Despite these reported benefits, enthusiasm for DR has been tempered by the observation that model organisms of different genotypes respond differently to DR (32, 77), with some genotypes even showing a reduced lifespan (31) or worsened health (96).…”

Section: Discussionmentioning

confidence: 99%

Genome-wide analysis reveals distinct genetic mechanisms of diet-dependent lifespan and healthspan inD. melanogaster

Wilson

Nelson

Beck

et al. 2017

Preprint

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27Dietary restriction (DR) robustly extends lifespan and delays age-related diseases across 28species. An underlying assumption in aging research has been that DR mimetics extend both 29 lifespan and healthspan jointly, though this has not been rigorously tested in different genetic 30 backgrounds. Furthermore, nutrient response genes important for lifespan or healthspan 31 extension remain underexplored, especially in natural populations. To address these gaps, we 32 utilized over 150 DGRP strains to measure nutrient-dependent changes in lifespan and age-33 related climbing ability to measure healthspan. DR extended lifespan and delayed decline in 34 climbing ability on average, but there was no evidence of correlation between these traits across 35 individual strains. Through GWAS, we then identified and validated jughead and Ferredoxin as 36 determinants of diet-dependent lifespan, and Daedalus for diet-dependent physical activity. 37Modulating these genes produced independent effects on lifespan and climbing ability, further 38suggesting that these age-related traits are likely to be regulated through distinct genetic 39 mechanisms. 40 peer-reviewed)

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Section: Discussionmentioning

confidence: 99%

Genome-wide analysis reveals distinct genetic mechanisms of diet-dependent lifespan and healthspan inD. melanogaster

Wilson

Nelson

Beck

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

“…AKT is also instrumental in angiogenesis and epithelial-to-mesenchymal transition during tumorigenesis [7]. Nude mouse experiments have shown that suppression of the PI3K/AKT signaling pathway can inhibit tumor growth, reduce angiogenesis, and improve the tumor microenvironment [8]. …”

Section: Introductionmentioning

confidence: 99%

Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice

Zhang

Yang

2014

J Transl Med

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BackgroundAdvanced hepatocellular carcinoma (HCC) patients undergo significant tumor growth and metastasis. Here, we investigated bufalin for treating HCC, which exhibits anti-tumor activities in many tumor cell lines.MethodIn our experiment, HCCLM3-R cells were injected into nude mice to form subcutaneous human HCC tumors that were implanted into the liver to establish orthotopic transplantation tumor models. Bufalin was injected intraperitoneally at 1 or 1.5 mg/kg. LY294002 (100 mg/kg), a potent inhibitor of Akt which reduced the levels of pAkt in HCCLM3 cell lines, was injected intraperitoneally into one group thrice weekly. The control was injected with an equal volume of saline. Morphological alterations were evaluated in the liver and lung by stereomicroscopy, the apoptotic rate was measured by TUNEL staining, and expression of AKT/GSK3β/β-catenin/E-cadherin signaling pathway-related proteins was detected by immunohistochemistry (IHC) and western blot analysis.ResultsThese results suggested that the sizes and qualities of orthotopic transplanted tumors as well as pulmonary metastasis decreased markedly at the highest bufalin dose compared with that in the control. Orthotopic transplanted tumor tissues were necrotic in bufalin-treated groups and the apoptotic cell number was markedly higher at the highest bufalin dose compared with that in the control. Certain changes of expression of AKT/GSK3β/β-catenin/E-cadherin signaling pathway-related proteins were in tumor tissues, which were related to the bufalin dose. Similar results were observed in the LY294002-treated group.ConclusionBased on the above, one can draw conclusions that bufalin has significant anti-tumor activities and reduces the metastatic potential in an orthotopic transplantation tumor model of human HCC. Inhibition of AKT/GSK3β/β-catenin/E-cadherin signaling pathways by bufalin may show therapeutic effects in advanced HCC patients.

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“…7) However, to date, there have been no reports of IFP concerning lung cancer, with the exception of experiments of human lung cancer xeno grafts in nude mice. 8,9) To our knowledge, this study is the first report of IFP in clinical cases of lung cancer.…”

Section: Discussionmentioning

confidence: 72%

“…8,9) Previously, IFP was generally determined via the wick inneedle or micropuncture technique. 10) However, a sim ple method for measuring IFP by using a polyurethane transducertipped catheter was recently developed, 11) and we used this technique to measure the IFP of lung cancer.…”

mentioning

confidence: 99%

Interstitial Fluid Pressure Correlates Clinicopathological Factors of Lung Cancer

Mori

Kinoshita

Shibata

et al. 2015

ATCS

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Dietary restriction suppresses tumor growth, reduces angiogenesis, and improves tumor microenvironment in human non-small-cell lung cancer xenografts

Cited by 19 publications

References 31 publications

Genome-wide analysis reveals distinct genetic mechanisms of diet-dependent lifespan and healthspan inD. melanogaster

Genome-wide analysis reveals distinct genetic mechanisms of diet-dependent lifespan and healthspan inD. melanogaster

Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice

Interstitial Fluid Pressure Correlates Clinicopathological Factors of Lung Cancer

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