Dietary Saccharomyces cerevisiae improves intestinal flora structure and barrier function of Pekin ducks

Gao, Wenwen; An, Keying; Li, Lei; Xia, Zhaofei

doi:10.1016/j.psj.2022.101940

Cited by 3 publications

(3 citation statements)

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“…Intestinal fungi, crucial for maintaining gut health and regulating immune responses, can cause complex health issues when dysbiosis. For instance, Saccharomyces cerevisiae has been shown to enhance both the intestinal immune response and the intestinal barrier. , Furthermore, a disrupted intestinal fungal community is strongly associated with diarrhea. , Studies indicate that polystyrene MPs exposure significantly alters the diversity and composition of gut microbiota, leading to dysbiosis . In the present study, polystyrene MPs disturbed the intestinal fungi community, notably increasing Candida and Cutaneotrichosporon abundances, while decreasing Diutina in both jejunum and ileum compared to the CON group.…”

Section: Discussionmentioning

confidence: 45%

“…For instance, Saccharomyces cerevisiae has been shown to enhance both the intestinal immune response and the intestinal barrier. 37,38 Furthermore, a disrupted intestinal fungal community is strongly associated with diarrhea. 39,40 Studies indicate that polystyrene MPs exposure significantly alters the diversity and composition of gut microbiota, leading to dysbiosis.…”

Section: Discussionmentioning

confidence: 99%

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Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway

Zou,

Yang,

et al. 2024

J. Agric. Food Chem.

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Due to the immature intestinal digestion, immunity, and barrier functions, weaned infants are more susceptible to pathogens and develop diarrhea. Microplastics (MPs), pervasive contaminants in food, water, and air, have unknown effects on the intestinal development of weaned infants. This study explored the impact of polystyrene MPs on intestinal development using a weaned piglet model. Piglets in the control group received a basal diet, and those in the experimental groups received a basal diet contaminated with 150 mg/kg polystyrene MPs. The results showed that exposure to polystyrene MPs increased the diarrhea incidence and impaired the intestinal barrier function of weaned piglets. Notably, the exposure led to oxidative stress and inflammation in the intestine. Furthermore, polystyrene MPs-treated weaned piglets showed a reduced level of intestinal angiogenesis. Mechanistically, polystyrene MPs suppressed methyltransferase-like 3 (METTL3) expression by increasing reactive oxygen species (ROS) production, consequently destabilizing angiogenic factors' mRNA and hindering intestinal angiogenesis. In summary, polystyrene MPs contamination in the diet increases diarrhea and compromises intestinal angiogenesis through the ROS/ METTL3 pathway, demonstrating their toxic effects on the intestine health of weaned infants.

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway

Zou,

Yang,

et al. 2024

J. Agric. Food Chem.

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“…The integrity of the gut epithelial layer serves as the primary physical barrier against the invasion of pathogenic antigens and is crucial for intestinal homeostasis and normal gut function [ 46 ]. Dietary supplementation with S. cerevisiae for 21 and 42 days was found to improve the intestinal barrier function of the ileum in Peking ducks, evidenced by increased mRNA expression levels of claudin-3, i-FABP, occludin, and ZO-1 [ 47 ]. Another study demonstrated that S. cerevisiae increased the relative content of gut barrier proteins, such as ZO-1, occludin, and claudin-1, and improved the integrity of the gut morphology in mice with ulcerative colitis [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Dietary Saccharomyces cerevisiae Supplementation on Gut Microbiota Composition and Gut Health in Aged Labrador Retrievers

Cui,

Li,

Zhang

et al. 2024

Animals

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The intestinal microbiome changes with age, influencing the host’s health and immune status. Saccharomyces cerevisiae (S. cerevisiae) positively affects intestinal function in humans and animals, but its effects on gut health and the microbiota profile in aged dogs have not been thoroughly investigated. Twenty aged Labrador Retrievers were divided into two groups: a control group (CON) and a S. cerevisiae group (SC). The experiment lasted for 42 days, with assessments of their intestinal barrier function, inflammatory factors, antioxidant markers, and fecal microbiome composition. The results showed that dietary S. cerevisiae reduced the levels of TNF-α, IL-6, and IL-1β in the serum (p < 0.05). In the SC group, plasma superoxide dismutase and glutathione peroxidase activities increased, while the level of malondialdehyde significantly decreased (p < 0.05). Additionally, dietary S. cerevisiae lowered the serum zonulin and lipopolysaccharide (LPS) levels (p < 0.05) and inhibited fecal ammonia production (p < 0.05). Furthermore, the microbiota profile showed that dietary S. cerevisiae decreased the abundance of Firmicutes but increased the Chao index, the abundance of Bacteroidetes, and the proportion of Bacteroidetes to Firmicutes (p < 0.05). To conclude, dietary S. cerevisiae can regulate the gut’s microbial structure and gut health, which may contribute to the overall health of companion animals as they age.

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Effect of composite yeast culture on the jejunal barrier function, inflammatory response, and microbial community structure of laying hens during the late stage of egg production

Luo,

Yang,

Tumenjargal

et al. 2024

Front. Vet. Sci.

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During the late laying period, the intestinal barrier of laying hens is susceptible to damage, resulting in enteric infections and even systemic inflammatory responses, posing a major challenge for the poultry industry. Therefore, it is crucial to investigate methods for addressing intestinal inflammation in late laying hens. In order to maximize the production potential of egg laying chickens, farmers usually use various feed additives to prevent damage to the intestinal barrier. Composite yeast cultures have shown advantages in broiler applications. This study aims to assess the impact of composite yeast culture (CYC) on the intestinal barrier function, inflammatory cytokines, and microbial community structure of Hy-Line Brown laying hens. A total of 160 healthy Hy-Line Brown hens, aged 58 weeks and of similar weight, were randomly assigned to two groups, with four replicates per group and 20 hens in each replicate. The control group was fed a basal diet (Con), while the experimental group was provided with a diet supplemented with 40 g/kg of composite yeast culture (CYC). The test period was 25 days. The results indicated that: compared to the control group, CYC significantly improved the egg production rates of hens during days 11–15, 16–20, and 21–25 (p < 0.05). CYC significantly enhanced the relative mRNA expression levels of occludin, claudin-1, zonula occludens-1 (ZO-1), and mucin 2 (Muc2) in the intestinal tract (p < 0.05), while reducing the relative expression levels of pro-inflammatory factors TNF-α and IFN-γ (p < 0.05), and increasing the levels of anti-inflammatory factors IL-4, IL-10, and TGF-β1 (p < 0.05). CYC significantly increased the abundance of Bifidobacterium pseudocatenulatum and Faecalibacterium prausnitzii in the intestine. These findings suggest that the composite yeast culture (CYC) can improve the structure of the intestinal microbial community. In conclusion, CYC may enhance egg production rates, reduce inflammatory responses, and strengthen intestinal barrier function by modulating the composition of the intestinal microbiota in late laying hens.

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Dietary Saccharomyces cerevisiae improves intestinal flora structure and barrier function of Pekin ducks

Cited by 3 publications

References 38 publications

Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway

Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway

The Effects of Dietary Saccharomyces cerevisiae Supplementation on Gut Microbiota Composition and Gut Health in Aged Labrador Retrievers

Effect of composite yeast culture on the jejunal barrier function, inflammatory response, and microbial community structure of laying hens during the late stage of egg production

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