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            -Arginine Reduces the Progression of Atherosclerosis in Cholesterol-Fed Rabbits

Böger, Rainer H.; Bode‐Böger, Stefanie M.; Brandes, Ralf P.; Phivthong-ngam, Laddaval; Böhme, M; Nafe, Reinhold; Mügge, Andreas; Frölich, Jürgen C.

doi:10.1161/01.cir.96.4.1282

Cited by 226 publications

(129 citation statements)

References 40 publications

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“…Besides its vasodilatory effects, NO has many reported antiatherogenic properties, including reducing platelet aggregability [40] , limiting vascular smooth muscle cell proliferation [41] , inhibiting adhesion molecule expression in endothelium [42] , inhibiting neutrophil and monocyte adhesion to the endothelium [43,44] , and preventing monocyte chemotaxis [45] . Chronic provision of L-arginine to the diets of hypercholesterolemic rabbits has been reported to improve endothelium-dependent vasodilation and reduce the extent of atherosclerotic lesions [46] . Also contributive to hyperlipidemia-mediated endothelial dysfunction is the increased production of reactive oxygen species (ROS, such as superoxide anion) and resultant abundance of reaction product peroxynitrite [37] .…”

Section: Vascular Dysfunction In Metabolic Syndrome (Hyper Lipidemia mentioning

confidence: 99%

Adiponectin resistance and vascular dysfunction in the hyperlipidemic state

Liang

2010

Acta Pharmacol Sin

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Insulin plays an important role in the stimulation of vascular nitric oxide production, with both short term (vasomotility and antithrombotic effects) and long term (smooth muscle cell growth and migration inhibition) benefits. Impaired vasodilatory response to insulin, the hallmark of vascular insulin resistance (IR), has important implications for circulatory pathophysiology. An association between adipokines and IR has been observed in both diabetic and nondiabetic states. Adiponectin (APN) is an insulin-sensitizing adipokine known to stimulate skeletal muscle fatty acid (FA) oxidation and reduce lipid accumulation. Recent demonstrations of potential cross-talk between APN and insulin in vascular function regulation are particularly interesting. The lipid accumulation observed after chronic high-fat (HF) diets and in the obese state may reduce vascular response to APN, a pathologic state termed as APN resistance. This review highlights the importance of insulin sensitivity and APN activity in the maintenance of endothelial function. It explores the relationships between vascular IR and APN resistance in the hyperlipidemic pathological condition, representative of the metabolic syndrome. The investigation of vascular insulin and APN resistance provides not only better understanding of vascular pathophysiology, but also an opportunity for therapeutic targeting in individuals affected by the metabolic syndrome.

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Section: Vascular Dysfunction In Metabolic Syndrome (Hyper Lipidemia mentioning

confidence: 99%

Adiponectin resistance and vascular dysfunction in the hyperlipidemic state

Liang

2010

Acta Pharmacol Sin

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“…(24)x. A reduction of NO synthesis predisposes to atherosclerosis (25). Oral administration of L-arginine has a protective effect with respect to plaque formation (18).…”

Section: Introductionmentioning

confidence: 99%

Developmental changes in the L-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age

Lücke¹,

Kanzelmeyer²,

Kemper³

et al. 2007

Clinical Chemical Laboratory Medicine

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Background: The L-arginine/nitric oxide (NO) pathway has multiple physiological functions including vasodilation, inhibition of platelet aggregation and neurotransmission. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of all known NO synthase isoforms, has adverse effects on renal and cardiovascular function in adults. It is unknown whether ADMA might also exert similar effects in younger individuals including infants. Also, reference data for important members of the L-arginine/NO family, notably ADMA and the NO metabolites, nitrite and nitrate, in infancy are lacking. Methods: In the present study, we investigated the status of the L-arginine/NO pathway in 34 healthy volunteers aged 2 days to 24 years by measuring the concentration of ADMA, nitrite, nitrate and L-arginine in plasma and urine using gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry methods. Results: We found that ADMA levels in plasma decreased with age (Pearson correlation coefficient rs-0.619, p-0.001). In contrast, urinary excretion of nitrate (rs0.471, ps0.036) and nitrite increased with age (rs0.484, ps0.037). Conclusions: Our study suggests that in infants ADMA biosynthesis accompanied by an inhibition of NO synthesis is higher than in adults and diminishes considerably with age. Clin Chem Lab Med 2007;45:1525-30.

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“…Reduction of plasma ADMA concentration has also been seen in response to probucol in rats [65]. In contrast, administration of L-arginine, the key substrate for NO synthase in the biosynthesis of NO, does not alter ADMA concentration but increased the L-arginine to ADMA ratio resulting in improved endothelium-dependent vasodilatation in animals and humans [38,49,50]. Of note, patients with unstable angina and reduced endothelium-dependent coronary vasodilatation had markedly improved anginal symptoms after 6 months of therapy with L-arginine (9 g/day) [66].…”

Section: Therapeutic Modulation Of Adma Concentrationsmentioning

confidence: 99%

“…It has been shown that by increasing plasma homocysteine concentrations using methionine infusion, FMD is impaired and this is associated with increased plasma ADMA [33]. Increased plasma concentrations of ADMA have also been described in a number of other conditions (Tables 1, 2) including diabetes mellitus, hypercholesterolaemia, hypertriglyceridaemia, hypertension, preeclampsia, stroke, peripheral vascular disease, congestive heart failure and acute coronary events [34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54]. Of interest, increased ADMA concentrations have also been implicated in the pathogenesis of conditions not affecting the cardiovascular system such as schizophrenia although the exact mechanism has yet to be clarified [55].…”

Section: Adma and Endothelial Dysfunction In Disease Statesmentioning

confidence: 99%

Asymmetric dimethylarginine (ADMA): a potential link between endothelial dysfunction and cardiovascular diseases in insulin resistance syndrome?

Chan

2002

Diabetologia

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Endothelium-derived nitric oxide plays a major role in the regulation of vascular tone and in the maintenance of vascular homeostasis. Endothelial dysfunction with impaired nitric oxide biosynthesis and decreased bioavailability has been implicated in insulin resistance syndrome and Type II (non-insulin-dependent) diabetes mellitus. Nitric oxide is synthesised by nitric oxide synthase. Asymmetric dimethylarginine is a major endogenous nitric oxide synthase inhibitor. Increased circulating asymmetric dimethylarginine was initially found in patients with chronic renal failure and subsequently many other disease states. Increased asymmetric dimethylarginine plasma concentrations could contribute to the development of insulin resistance and coronary heart disease. Understanding of the pathophysiological role of asymmetric dimethylarginine could lead to novel therapies in the prevention of arteriosclerosis and coronary heart disease. [Diabetologia (2002[Diabetologia ( ) 45:1609[Diabetologia ( -1616

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Dietary l -Arginine Reduces the Progression of Atherosclerosis in Cholesterol-Fed Rabbits

Cited by 226 publications

References 40 publications

Adiponectin resistance and vascular dysfunction in the hyperlipidemic state

Adiponectin resistance and vascular dysfunction in the hyperlipidemic state

Developmental changes in the L-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age

Asymmetric dimethylarginine (ADMA): a potential link between endothelial dysfunction and cardiovascular diseases in insulin resistance syndrome?

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