Dietary selenium and selenoprotein function

Weeks, Benjamin S.; Hanna, Mirna S.; Cooperstein, Deborah

doi:10.12659/msm.883258

Cited by 51 publications

(24 citation statements)

References 71 publications

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“…Depending on geological conditions, selenium is found in soil and water and consequently enters the food chain [ 8 ] . Low selenium rock types with a content of 0.05-0.09 mg Se/kg are prevalent worldwide [ 9 ] .…”

Section: Selenium Levels In Patients With Autoimmune Thyroiditis and mentioning

confidence: 99%

Selenium Levels in Patients with Autoimmune Thyroiditis and Controls in Lower Austria

et al. 2014

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Autoimmune thyroiditis (AIT) is one of the most common autoimmune diseases; genetic as well as environmental factors contribute to its pathogenesis. The thyroid is the organ with the highest selenium content per unit weight. Selenium status appears to have an impact on the development of thyroid pathologies. We investigated a possible difference of selenium serum levels as a marker of nutritional selenium supply between patients with AIT in central Lower Austria and a matched group of healthy persons living in the same region. Selenium serum levels in the patients with AIT were 98.0 ± 15.6 μg/l. A significant difference to the matched group of normal persons, whose selenium serum levels were 103.2 ± 12.4 μg/l, could not be detected by the t-test (p>0.05). We considered the serum selenium levels to be indicators of selenium supply (by alimentation). A serum level of 120-160 μg/l of selenium represents the normal range. According to this, most patients and control persons showed mild to moderate selenium deficiency (80-120 μg/l selenium). Although our data present slightly higher selenium levels in normal persons than in patients with AIT, this weak and statistically insignificant trend is not sufficient to support the conclusion of a link between inadequate selenium supply and autoimmune thyroid disease.

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Section: Selenium Levels In Patients With Autoimmune Thyroiditis and mentioning

confidence: 99%

Selenium Levels in Patients with Autoimmune Thyroiditis and Controls in Lower Austria

et al. 2014

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“…Selenium is a trace element with a significant role in sustaining health. It is a cofactor of glutathione peroxidase (GPx) and protects cells against reactive oxygen species (ROS) (12,13). Vitamin C has endogenous antioxidant features, and it has synergistic effects in combination with vitamin E that protect low-density lipoprotein from oxidative stress induced by peroxyl radicals (14,15).…”

Section: Introductionmentioning

confidence: 99%

An Antioxidant Combination Improves Histopathological Alterations and Biochemical Parameters in D-Galactosamine- Induced Hepatotoxicity in Rats

Çatal¹,

Tunalı²,

Bolkent³

et al. 2017

Eur J Biol

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The protective effects of a combination of antioxidants on histopathological changes and biochemical parameters were examined in D-galactosamine (D-GaIN)-induced hepatotoxicity in rats. Physiological saline solution was injected intraperitoneally into the control group, while D-GaIN (500 mg kg-1) was administered intraperitoneally into the experimental animals. The combination of 100 mg/kg/day ascorbic acid, 100 mg/kg/day alpha tocopherol, 15 mg/kg/day beta carotene, and 0.2 mg/kg/day sodium selenate was administered orally to intact control rats for 3 days. The same antioxidant combination was given to the D-GaIN group. Liver and blood samples were used for histopathological and biochemical assays. Liver tissues were significantly damaged by D-GaIN administration based on the histopathological findings. Serum aspartate and alanine transaminase, gamma glutamyl transpeptidase, alkaline phosphatase, lactate dehydrogenase, sialic acid, and uric acid levels increased. Serum and liver glutathione levels decreased, and serum superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase, catalase activities as well as lipid peroxidation values increased in the D-GaIN group. In contrast, administration of the antioxidants reversed the histopathological and biochemical changes in the liver of animals administered D-GaIN. In conclusion, the administration of a combination of antioxidants suppressed histopathological changes and biochemical parameters in rats given D-GaIN.

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“…The physiological effects of selenium vary widely and include active thyroid hormone production, proper immune system functioning, fertility, reduced cancer risk and anti-oxidant function [1][2][3][4]. Selenium deficiency is quite rare among individuals who consume an ordinary diet, because foods such as meats, seafood, grains and milk contain selenium.…”

Section: Introductionmentioning

confidence: 99%

Selenium deficiency in children and adolescents nourished by parenteral nutrition and/or selenium-deficient enteral formula

Etani

Nishimoto

Kawamoto

et al. 2014

Journal of Trace Elements in Medicine and Biology

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Dietary selenium and selenoprotein function

Cited by 51 publications

References 71 publications

Selenium Levels in Patients with Autoimmune Thyroiditis and Controls in Lower Austria

Selenium Levels in Patients with Autoimmune Thyroiditis and Controls in Lower Austria

An Antioxidant Combination Improves Histopathological Alterations and Biochemical Parameters in D-Galactosamine- Induced Hepatotoxicity in Rats

Selenium deficiency in children and adolescents nourished by parenteral nutrition and/or selenium-deficient enteral formula

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