Dietary Selenium Intake and Genetic Polymorphisms of the GSTP1 and p53 Genes on the Risk of Esophageal Squamous Cell Carcinoma

Abstract

Few studies have assessed potential effect modifications by polymorphisms of susceptibility genes on the association between selenium intake and esophageal squamous cell carcinoma (ESCC). We studied the joint effects of dietary selenium and the GSTP1 and p53 polymorphisms on ESCC risk in a population-based case-control study with 218 ESCC cases and 415 controls in Taixing City, China. Dietary selenium intake was estimated from a food frequency questionnaire with 97 food items. GSTP1 and p53 polymorphisms were detected by RFLP-PCR assays. Logistic regression analyses were done to estimate odds ratios (OR) and 95% confidence intervals (95% CI). Reduced ESCC risk was observed among individuals in the highest quartile of dietary selenium intake (adjusted OR, 0.31; 95% CI, 0.13-0.70) with a dose-dependent gradient (P trend = 0.01).

Association of genetic polymorphisms in MDM2, PTEN and P53 with risk of esophageal squamous cell carcinoma

“…20,21 In spite of the above discrepancy, we observed a similar association between P53 Arg72Pro and ESCC risk compared with Hong's and other previous studies (OR B2 for Pro/Pro genotype compared with Arg/Arg genotype, adjusted for age, sex, smoking or drinking status), though sample size, matching mode and study population were quite different from each other. [13][14][15][16] We confirm that P53 Arg72Pro polymorphism is a common susceptibility factor for ESCC in Chinese populations.…”

“…11,12 Till now, the P53 Arg72Pro polymorphism has been well studied in ESCC in Chinese populations. [13][14][15][16] But little is known about the association between MDM2 or PTEN polymorphisms and ESCC susceptibility. 16,17 Here we genotyped MDM2 T309G, Del1518 (rs150550023), PTEN rs701848 and rs2735343 and investigated the associations between these polymorphisms and ESCC risk in a case-control study conducted in a high-risk population of China.…”

p53 Codon 72 Polymorphism Interactions with Dietary and Tobacco Related Habits and Risk of Stomach Cancer in Mizoram, India

“…However, this distribution of Pro/Pro genotype is quite high in comparison to most of the ethnic groups of Indian studies, although Sameer et al, (2010) reported higher distribution (45.4%) of Pro/Pro genotype in colorectal cancer cases in Kashmir. Four studies from China (Mu et al, 2005;Cai et al, 2006;Yang et al, 2007;Shao et al, 2008) also reported higher distribution of homozygous Pro genotypes in stomach and oesophageal cancer cases ranging from 26.4% to 36.3%. Meta-analysis of Zhou et al, (2007) reported a significant lower frequency of Arg allele in Asian gastric cancer patients.…”

Association of the p53 Arg72Pro polymorphism with esophageal cancer in Chinese populations: a meta-analysis

“…Eventually, 13 case-control studies (12 articles) (Lee et al, 2000;Peixoto Guimaraes et al, 2001;Li et al, 2002;Zhang et al, 2002Zhang et al, , 2003Hu et al, 2003;Hong et al, 2005; Cai et al, 2006;Cao et al, 2007;Shao et al, 2008;Zhang, 2008;Li, 2012) were included and 176 articles were excluded. The publication years of the included studies ranged from 2000 to 2012.…”