Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study

Andrade, Gustavo Rosa Gentil; Gorgulho, Bartira Mendes; Lotufo, Paulo A; Benseñor, Isabela M.; Marchioni, Dirce Maria Lobo

doi:10.3390/nu10060693

Cited by 29 publications

(16 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dietary selenium intake measured with food frequency questionnaires showed an inverse association with SH, independent of the intake of energy (kcal) and other nutrients. The more selenium Brazilian adults consumed with their daily food intake, the lower the incidence of SH [18]. When evaluated in a meta-analysis, selenium as a supplement did not alter thyroid function, nor did it improve clinical symptoms [19].…”

Section: Introductionmentioning

confidence: 95%

A Lifestyle (Dietary) Intervention Reduces Tiredness in Children with Subclinical Hypothyroidism, a Randomized Controlled Trial

Gaag

Palen

Schaap

et al. 2020

IJERPH

View full text Add to dashboard Cite

Purpose: Subclinical hypothyroidism (SH) in children and adults is a subject for discussion in terms of whether to treat it or not with respect to the short-term clinical implications and consequences of SH and in the long term. If treatment with thyroxine supplementation is not indicated, no other treatment is available. We investigated whether a lifestyle (dietary) intervention improves or normalizes SH or decreases the presence of Thyroid Stimulating Hormone (TSH) and/or tiredness. Methods: We randomized children aged 1–12 years with SH to the control group (standard care = no treatment) or intervention group (dietary intervention). The dietary intervention consisted of green vegetables, beef, whole milk and butter for 6 months. The rest of the diet remained unchanged. We measured TSH, FreeT4, Lipid profile, Body Mass Index (BMI) and Pediatric Quality of Life (PedQL) multidimensional fatigue scale scores. Results: In total, 62 children were included. After 6 months, TSH decreased in both groups without a significant difference between the groups (p = 0.98). PedQL fatigue scores for sleep (p = 0.032) and total fatigue scores (p = 0.039) improved significantly in the intervention group, compared to the control group. No unfavorable effects occurred in the lipid profile or BMI. Conclusion: The lifestyle (dietary) intervention did not normalize SH and TSH levels, but it significantly reduced tiredness. These results suggest that children’s well-being can be improved without medication.

show abstract

Section: Introductionmentioning

confidence: 95%

A Lifestyle (Dietary) Intervention Reduces Tiredness in Children with Subclinical Hypothyroidism, a Randomized Controlled Trial

Gaag

Palen

Schaap

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…43 No entanto, os níveis de Se no organismo variam em todo o mundo, pois dependem das características da população e de sua dieta e área geográfica, principalmente da composição do solo. 25,44 A selenocisteína, um análogo de Se do aminoácido cisteína, é encontrada principalmente em alimentos de origem animal. As formas inorgânicas (selenato e selenito) são os componentes dos suplementos alimentares, sendo metabolizadas em selenocisteína e incorporadas em selenoenzimas.…”

Section: Gestantesunclassified

“…7 Em dietas deficientes em Se, os órgãos endócrinos e o cérebro são supridos preferencial-mente, especialmente a tireoide, que retém o oligoelemento de maneira muito eficiente. 44 Zinco O zinco (Zn) é um oligoelemento essencial para o homem, e se encontra amplamente distribuído em todo o corpo, mas em pequenas concentrações. O papel do Zn tem sido cada vez mais ressaltado, e há progresso dos conhecimentos nos aspectos bioquímicos, imunológicos e clínicos.…”

Section: Gestantesunclassified

Micronutrient Influence in Thyroid Function: A Review

Nóbrega

2019

International Journal of Nutrology

View full text Add to dashboard Cite

The thyroid produces and secretes adequate amounts of hormones that regulate various physiological processes, including growth, development, metabolism, and reproductive function. The production and metabolism of thyroid hormones are dependent on micronutrients such as iodine, selenium, zinc and iron. Iodine is essential for the proper synthesis of thyroid hormones. The risk of iodine deficiency is high in places where the food consumed comes from iodine-deficient sources. To avoid complications, various government strategies have been developed to enrich food with this element. Selenium is incorporated in the deiodinases, which are enzymes that also play an essential role in the metabolism of thyroid hormones, in addition to contributing to the antioxidant defense in the thyroid. Zinc participates in the process of deiodination, in addition to being necessary for the T3 receptor to adopt its biologically active confirmation. Iron is found in hemeproteins, including thyroid peroxidase (TPO), which participates in the first two stages of thyroid hormone biosynthesis. Deficiencies of these elements can impair thyroid function. In general, the influence of micronutrients on thyroid function reveals the need for more research to increase scientific knowledge so that preventive and therapeutic measures can be taken regarding thyroid dysfunctions, to maintain a healthy thyroid.

show abstract

“…These micronutrients are mainly sourced and supplemented from daily dietary intake. Daily diet is crucial in the development and prevention of thyroid disease 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Association Between Dietary Onion Intake and Subclinical Hypothyroidism in Adults: A Population-Based Study From an Lodine-Replete Area

zhang

Meng

et al. 2021

Preprint

View full text Add to dashboard Cite

Background & AimsThe protective effect of onion against thyroid hypofunction has been reported in animal studies. However, in humans, the association between onion consumption and subclinical hypothyroidism are unclear. The study sought to explore the association between habitual onion intake and subclinical hypothyroidism among adult population from an iodine-replete area.ObjectiveWe aimed to investigate the relationship between dietary onion intake and subclinical hypothyroidism in Chinese populationMethodsA cross-sectional study (6,515 men and 5,290 women) was performed in Tianjin, China. Frequency of onion consumption was assessed using a valid self-administered food frequency questionnaire. Serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) were determined by chemiluminescence immunoassay. Subclinical hypothyroidism was diagnosed with TSH >4.78 IU/mL. Multiple logistic regression was used to evaluate the association of onion intake with subclinical hypothyroidism.ResultsThe prevalence of subclinical hypothyroidism was 2.56% in men and 7.18% in women, respectively. In women, the fully adjusted odds ratios [95% confidence interval (CI)] of having subclinical hypothyroidism across increasing frequency of onion intake were 1.00 (reference) for <1 time/week, 0.99 (0.74-1.34) for 1-3 times/week, 0.73 (0.53-1.01) for 4-6 times/week, and 0.66 (0.46-0.95) for ≥7times/week (P for trend <0.01). However, we observed no significant association between onion intake and subclinical hypothyroidism in men. Stratified analyses suggested a potential effect modification by age; the odds ratios (95% CI) across extreme quartiles was 0.43 (0.20, 0.87) in <40 women and 1.05 (0.49, 2.28) in >60 women.ConclusionsFrequent consumption of onion is inversely associated with subclinical hypothyroidism in adult women from an iodine-replete area. Further studies are needed to explore the casual relationship.

show abstract

Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study

Cited by 29 publications

References 51 publications

A Lifestyle (Dietary) Intervention Reduces Tiredness in Children with Subclinical Hypothyroidism, a Randomized Controlled Trial

A Lifestyle (Dietary) Intervention Reduces Tiredness in Children with Subclinical Hypothyroidism, a Randomized Controlled Trial

Micronutrient Influence in Thyroid Function: A Review

Association Between Dietary Onion Intake and Subclinical Hypothyroidism in Adults: A Population-Based Study From an Lodine-Replete Area

Contact Info

Product

Resources

About