Dietary Selenium Intakes and Musculoskeletal Function in Very Old Adults: Analysis of the Newcastle 85+ Study

Perri, Giorgia; Mendonça, Nuno; Jagger, Carol; Walsh, Jennifer; Eastell, Richard; Mathers, John C.; Hill, Tom R.

doi:10.3390/nu12072068

Cited by 16 publications

(9 citation statements)

References 116 publications

(140 reference statements)

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“…The oxidative stress subsequently impairs cartilage and further leads to OA. However, as indicated by Perri et al (17), low dietary selenium intake was common in the elderly. And the study by Wang et al (8) was carried out among participants over 50 years old and the elderly are prone to OA, which may bias the findings.…”

Section: Discussionmentioning

confidence: 93%

A national cross-sectional analysis of selenium intake and risk of osteoarthritis: NHANES 2003–2016

Deng

Tan

2023

Front. Public Health

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BackgroundThe association between dietary selenium intake and arthritis, rheumatoid arthritis (RA), and osteoarthritis (OA) is inconsistent in previous studies and remain unclear. To investigate their relationship, this study was performed.MethodsData from the National Health and Nutrition Examination Survey (2003–2016) were downloaded and further analyzed. Dietary Se intake was classified according to quartiles with quartile 1 (Q1) having the lowest intake and quartile 4 (Q4) having the highest intake. Weighted logistic regression was used to investigate the association between dietary selenium intake and arthritis, RA, and OA. Subgroup analyses were performed to verify the findings. To further examine the non-linear relationship between dietary selenium intake and OA, restricted cubic spline (RCS) was adopted.ResultsIn the crude model, the highest level of dietary selenium intake was siginificantly associated with decreased risks of arthritis (OR: 0.40, 95% CI: 0.37, 0.44) and rheumatoid arthritis (OR: 0.47, 95% CI: 0.40, 0.54), respectively. In the fully adjusted model, dietary selenium intake was not associated with risk of arthritis and RA (all P > 0.05). Conversely, the risk of OA was noted for participants with higher selenium intake (odds ratio of quartile 4 = 1.33, 95% CI = 1.07–1.65, P < 0.05). In the subgroup analyses, participants with diabetes had a higher risk of OA when ingested high selenium levels than those without diabetes (P < 0.001). The results of RCS showed that significant overall trends were found between dietary selenium intake and osteoarthritis (P for overall < 0.05). However, non-linear association was not detected in this association (P for non-linear > 0.05).ConclusionUsing data from NHANES, this study discloses that high dietary selenium intake might be associated with risk of OA. However, the generalization of conclusion needs further examination because of the limitation of dietary questionnaire survey.

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Section: Discussionmentioning

confidence: 93%

A national cross-sectional analysis of selenium intake and risk of osteoarthritis: NHANES 2003–2016

Deng

Tan

2023

Front. Public Health

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“…24 Lower serum selenium and dietary selenium are associated with lower muscle mass and poorer muscle function in older adults. 27,[47][48][49] The proposed mechanism of action of selenium to reduce reactive oxygen species, and therefore reduce the pro-resorptive drive to osteoclasts, was plausible. However, we saw no effect at all on markers of bone resorption.…”

Section: Resultsmentioning

confidence: 99%

Selenium supplementation to improve bone health in postmenopausal women: the SeMS three-arm RCT

et al. 2021

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Background Observational and pre-clinical studies have reported an association between selenium status, bone density, bone turnover and fracture risk. Selenium is an anti-oxidant, so we hypothesised that selenium could reduce the pro-resorptive action of reactive oxygen species on osteoclasts. Population mortality data suggest that the optimum range for serum selenium is 120–150 µg/l. Most adults in Europe are relatively selenium insufficient compared with adults in the USA and other geographical areas. Objectives The objectives of the study were to determine if selenium supplementation in postmenopausal women with osteopenia decreased bone turnover, improved physical function or decreased markers of oxidative stress and inflammation. Design We conducted a 6-month double-blind, randomised, placebo-controlled trial. Setting This was a single-centre study in Sheffield, UK. Participants We recruited 120 postmenopausal women with osteopenia or osteoporosis. One hundred and fifteen women completed follow-up and were included in the intention-to-treat analysis. Interventions The interventions were sodium selenite as Selenase 200 µg/day, Selenase 50 µg/day (biosyn, Germany) and placebo. Main outcome measures The primary end point was urine N–terminal cross-linking telopeptide of type I collagen/Cr (NTX/Cr) at 26 weeks. Groups were compared with an analysis of covariance, through the use of Hochberg testing. Secondary end points were other biochemical markers of bone turnover, bone mineral density by dual-energy X-ray absorptiometry and physical function scores (short physical performance battery and grip strength). The mechanistic end points were markers of inflammation and anti-oxidant activity (glutathione peroxidase, highly sensitive C-reactive protein and interleukin 6). Results In the 200 µg/day group, mean serum selenium increased from 78.8 µg/l (95% confidence interval 73.5 to 84.2 µg/l) to 105.7 µg/l (95% confidence interval 99.5 to 111.9 µg/l) at 26 weeks. Urine NTX/Cr did not differ between treatment groups at 26 weeks. None of the secondary or mechanistic end-point measurements differed between the treatment groups at 26 weeks. Conclusions We conclude that selenium supplementation at these doses does not affect bone turnover (assessed by NTX/Cr) and is not beneficial for musculoskeletal health in postmenopausal women. Trial registration IRAS 200308, EudraCT 2016-002964-15 and ClinicalTrials.gov NCT02832648. Funding This project was funded by the Efficacy and Mechanism Evaluation (EME) programme, a MRC and National Institute for Health Research (NIHR) partnership. This will be published in full in Efficacy and Mechanism Evaluation; Vol. 8, No. 6. See the NIHR Journals Library website for further project information.

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“…Physical activity was assessed using a purpose-built questionnaire and validated by comparison with accelerometery ( 28 ) . Se intake (µg/d), total energy intake (kcal) and protein intake (g) were determined using the 24-h multiple pass recall ( 11 , 29 ) . Disease count was calculated using a selected list of chronic diseases (online Supplementary Material Table ) ( 24 ) .…”

Section: Methodsmentioning

confidence: 99%

“…To date, there is limited information on dietary intake of Se among very old adults. However, an earlier analysis using data from ≥ 85-year-olds ( n 791) from the Northeast of England who participated in the Newcastle 85+ Study found that over 50 % had dietary Se intakes below the lower reference nutrient intake ( 11 ) .…”

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confidence: 99%

Selenium status and its determinants in very old adults: insights from the Newcastle 85+ Study

Perri,

Mathers,

Martin-Ruiz

et al. 2023

Br J Nutr

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There is a dearth of data on selenium status in very old adults. The aims of this study were to assess selenium status and its determinants in 85-year-olds living in the Northeast of England by measuring serum selenium and selenoprotein P (SELENOP) concentrations and glutathione peroxidase 3 (GPx3) activity. A secondary aim was to examine the interrelationships between each of the biomarkers. In total, 757 participants (463 women, 293 men) from The Newcastle 85+ Study were included. Biomarker concentrations were compared with selected cut-offs (serum selenium: suboptimal 70 µg/L and deficient 45 µg/L; SELENOP: suboptimal 4.5 mg/L and deficient 2.6 mg/L). Determinants were assessed using linear regressions and interrelationships were assessed using restricted cubic splines. Median (IQR) concentrations of serum selenium, SELENOP and of GPx3 activity were 53.6 (23.6) µg/L, 2.9 (1.9) mg/L and 142.1 (50.7) U/L, respectively. Eighty-two percent, and 83 % of participants had suboptimal serum selenium (< 70 µg/L) and SELENOP (< 4.5 mg/L), and 31 % and 40 % of participants had deficient serum selenium (< 45 µg/L) and SELENOP (< 2.6 mg/L), respectively. Protein intake was a significant determinant of selenium status. Additional determinants of serum selenium were gender, waist:hip ratio, self-rated health, and disease, whilst gender, BMI and physical activity were determinants of GPx3 activity. There was a linear association between serum selenium and SELENOP, and nonlinear associations between serum selenium and GPx3 activity and between SELENOP and GPx3 activity. These findings indicate that most participants had suboptimal selenium status to saturate circulating SELENOP.

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Dietary Selenium Intakes and Musculoskeletal Function in Very Old Adults: Analysis of the Newcastle 85+ Study

Cited by 16 publications

References 116 publications

A national cross-sectional analysis of selenium intake and risk of osteoarthritis: NHANES 2003–2016

A national cross-sectional analysis of selenium intake and risk of osteoarthritis: NHANES 2003–2016

Selenium supplementation to improve bone health in postmenopausal women: the SeMS three-arm RCT

Selenium status and its determinants in very old adults: insights from the Newcastle 85+ Study

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