Dietary Selenium Promotes Somatic Growth of Rainbow Trout (Oncorhynchus mykiss) by Accelerating the Hypertrophic Growth of White Muscle

Wang, Li; Zhang, Dianfu; Li, Sai; Wang, Long; Yin, Jiaojiao; Xu, Zhen; Zhang, Xuezhen

doi:10.1007/s12011-020-02282-w

Cited by 22 publications

(11 citation statements)

References 44 publications

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“…Histological characteristics of zebrafish skeletal muscle at the vent level showed that the total area of white muscle and muscle fibre diameter in zebrafish fed the DSe were significantly lower than those in zebrafish fed the ASe, suggesting a suppressive effect of Se deficiency on hypertrophic growth of zebrafish skeletal muscle. This phenomenon is completely consistent with previous observations both in zebrafish (19) and rainbow trout (20,21) .…”

Section: Discussionsupporting

confidence: 94%

“…Se deficiency has been reported to downregulate the expression of multiple selenoprotein genes those code antioxidant selenoproteins, including Gpx1, Gpx4, Selenok, Selenop, Selenou and Selenow in fish skeletal muscle (18,19,21) . A similar phenomenon has also been observed in this study that the mRNA level of gpx1a , gpx4a , selenok , selenop1a , selenou1a and selenow1 significantly decreased in skeletal muscle of zebrafish fed the DSe compared with those fed the ASe.…”

Section: Discussionmentioning

confidence: 99%

“…In fish skeletal muscle, Se deficiency has been reported to decrease mRNA levels of multiple selenoprotein genes, such as glutathione peroxidase (gpx) 1, gpx4, selenou, selenow, selenop and selenok. (18,19,21) It is well known that these genes encode antioxidative selenoproteins (29,30) . Down-regulation of them has been reported to be associated with decreased antioxidative capacity and increased reactive oxygen species (ROS) concentration in various tissues and cell types (31)(32)(33)(34)(35) .…”

mentioning

confidence: 99%

“…For fish skeletal muscle, a few researches in rainbow trout ( Oncorhynchus mykiss ) and zebrafish ( Danio rerio ) demonstrated that its growth rate is much sensitive to the change of body Se status and exhibits a clearly decrease once fish suffer from Se deficiency. The results of histological identification suggest that Se deficiency-caused growth retardation of fish skeletal muscle is primarily attributed to the suppressed muscle fibre hypertrophy (19–21) . However, the underlying mechanisms are still not well studied.…”

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confidence: 99%

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Selenium deficiency-induced high concentration of reactive oxygen species restricts hypertrophic growth of skeletal muscle in juvenile zebrafish by suppressing TORC1-mediated protein synthesis

et al. 2023

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Selenium (Se) deficiency causes impaired growth of fish skeletal muscle due to the retarded hypertrophy of muscle fibers. However, the inner mechanisms remain unclear. According to our previous researches, we infer this phenomenon is associated with Se deficiency-induced high concentration of reactive oxygen species (ROS), which could suppress the target of rapamycin complex 1 (TORC1) pathway-mediated protein synthesis by inhibiting protein kinase B (Akt), an upstream protein of TORC1. To test this hypothesis, juvenile zebrafish (45 days post fertilization) were fed a basal Se-adequate diet or a basal Se-deficient diet, or them supplemented with an antioxidant (DL-α-tocopherol acetate, designed as VE) or a TOR activator (MHY1485) for 30 days. Zebrafish fed Se-deficient diets exhibited a clear Se-deficient status in skeletal muscle, which was not influenced by dietary VE and MHY1485. Se deficiency significantly elevated ROS concentrations, inhibited Akt activity and TORC1 pathway, suppressed protein synthesis in skeletal muscle, and impaired hypertrophy of skeletal muscle fibers. However, these negative effects of Se deficiency were partly (except that on ROS concentration) alleviated by dietary MHY1485 and completely alleviated by dietary VE. These data strongly support our speculation that Se deficiency-induced high concentration of ROS exerts a clear inhibiting effect on TORC1 pathway-mediated protein synthesis by regulating Akt activity, thereby restricting the hypertrophy of skeletal muscle fibers in fish. Our findings provide a mechanistic explanation for Se deficiency-caused retardation of fish skeletal muscle growth, contributing to a better understanding of the nutritional necessity and regulatory mechanisms of Se in fish muscle physiology.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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Selenium deficiency-induced high concentration of reactive oxygen species restricts hypertrophic growth of skeletal muscle in juvenile zebrafish by suppressing TORC1-mediated protein synthesis

et al. 2023

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“…In addition, tenderness also depends on myofibrillar protein degradation implicated by the calpain family (µ-calpain, m-calpain, and calpain3) and a specific inhibitor, the calpastatin ( Morton et al, 1999 ). Wang et al (2020) reported dietary Se could interfere with the expression of calpain and calpastatin in rainbow trout, suggesting that the calpain family may change the tenderness of breast muscle due to Se treatment.…”

Section: Discussionmentioning

confidence: 99%

Effect of supplementing hydroxy selenomethionine on meat quality of yellow feather broiler

Tang

Liu³

et al. 2021

Poultry Science

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This study was conducted to evaluate the effect of supplementing hydroxy selenomethionine ( OH-SeMet ) on performance, selenium ( Se ) deposition in the breast muscle, quality and oxidative stability, and expression of selenoprotein encoding genes of breast meat of the native slow-growing yellow-feathered broiler birds. A total of 375 one-day-old local yellow male birds were randomly assigned into 5 dietary treatments, supplemented with Se 0.0, 0.2, 0.4, 0.6, and 0.8 mg/kg in the form of OH-SeMet. Each treatment consisted of 5 replicates and each replicate had 15 birds, the birds were fed on basal diet containing corn and soybean meal, and the experiment lasted for 63 d. The results showed that dietary Se supplementation linearly increased ( P < 0.001) Se contents in both serum and muscle, no significant changes ( P > 0.05) were observed on growth performance, yield of breast, meat color, and intramuscular fat deposition of the breast muscle. Dietary Se addition improved water-holding capacity, the pH 24h value, and tenderness of breast muscle, evidenced by a linear decreases of shear force ( P < 0.05), accompanied by lower thiobarbituric acid reactive substances and higher glutathione reductase activity. The mRNA abundance of selenoprotein encoding genes also responded to dietary Se levels. It is concluded that, dietary supplementation with OH-SeMet improved muscular Se deposition and meat quality of the native yellow birds, with enhanced antioxidant capability and regulation in selenogenome.

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Impact of dietary selenium supplementation on growth performance, bioaccumulation, antioxidant capacity, and gene expression in GIFT strain of Nile Tilapia (Oreochromis niloticus)

Thangarani,

Felix,

Suresh

et al. 2024

Aquacult Int

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Dietary Selenium Promotes Somatic Growth of Rainbow Trout (Oncorhynchus mykiss) by Accelerating the Hypertrophic Growth of White Muscle

Cited by 22 publications

References 44 publications

Selenium deficiency-induced high concentration of reactive oxygen species restricts hypertrophic growth of skeletal muscle in juvenile zebrafish by suppressing TORC1-mediated protein synthesis

Selenium deficiency-induced high concentration of reactive oxygen species restricts hypertrophic growth of skeletal muscle in juvenile zebrafish by suppressing TORC1-mediated protein synthesis

Effect of supplementing hydroxy selenomethionine on meat quality of yellow feather broiler

Impact of dietary selenium supplementation on growth performance, bioaccumulation, antioxidant capacity, and gene expression in GIFT strain of Nile Tilapia (Oreochromis niloticus)

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