Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress

Huang, Xin; Dong, Yulan; Li, Tong; Xiong, Wei; Zhang, Xu; Wang, Pengjie; Huang, Jia‐Qiang

doi:10.3390/nu13051527

Cited by 10 publications

(6 citation statements)

References 129 publications

(131 reference statements)

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“…Notably, our results indicated a significant reduction in miR-21 levels not only in response to a generally healthy diet but also, more specifically, upon analysing the consumption of fruits and vegetables. A healthy dietary pattern has the potential to modulate miRNA activity through various pathways: bioactive compounds such as resveratrol, curcumin, quercetin, and catechins as well as minerals or vitamins and polyunsaturated fatty acids (PUFAS) have been reported to directly modulate miRNA expression [ 86 , 87 , 88 , 89 , 90 , 91 , 92 ]. For instance, eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids as well as polyphenols exert part of their anti-inflammatory action by downregulating miRNAs like miR-146a, miR-21, and miR-155, particularly after macrophage and epithelial cell stimulation while mediating NF-κB signalling [ 64 , 92 ].…”

Section: Discussionmentioning

confidence: 99%

Lifestyle-Driven Variations in Nutrimiromic MicroRNA Expression Patterns across and beyond Genders

Pointner,

Krammer,

Tomeva

et al. 2024

Life

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The importance of diet and lifestyle in maintaining overall health has long been recognised. MicroRNAs (miRNAs) have emerged as key players in the intricate interplay between health and disease. This study, including 305 participants, examined the role of miRNAs from capillary blood as indicators of individual physiological characteristics, diet, and lifestyle influences. Key findings include specific miRNAs associated with inflammatory processes and dietary patterns. Notably, miR-155 was associated with subjects with metabolic diseases and upregulated in age. Additionally, the study revealed diet-related miRNA expressions: high consumption of vegetables, fruits, and whole grains correlated with increased levels of miR-let-7a and miR-328, both implicated in anti-inflammatory pathways, and decreased expression of pro-inflammatory miR-21. In the context of smoking, we found a significant decrease in miRNA-142, known for its downregulation in lung cancer. We observed a sex-biased expression of various miRNAs with significant upregulation of miR-151a in females and a higher expression of miR-155 in ageing females, representing a possible mechanism for the increased susceptibility to autoimmune diseases. In conclusion, the study underscores the significant influence of lifestyle, nutrition, and sex on miRNA profiles. Circulating miRNAs demonstrate significant potential as biomarkers in personalized medicine, highlighting their utility in tailoring healthcare to individual needs.

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Section: Discussionmentioning

confidence: 99%

Lifestyle-Driven Variations in Nutrimiromic MicroRNA Expression Patterns across and beyond Genders

Pointner,

Krammer,

Tomeva

et al. 2024

Life

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“…Selenate is reduced to selenite prior to further metabolism, and this reduction process is catalyzed by selenate and selenite reductases. [91][92][93] Avazeri et al found that nitrate reductases A and Z can reduce selenite to selenate. [93] Meanwhile, Se (IV) reacts with the reduced GSH to generate selenodiglutathione (GS-Se-SG).…”

Section: Mechanism Of Se Enrichment By Probioticsmentioning

confidence: 99%

Advances in the Study of Selenium‐Enriched Probiotics: From the Inorganic Se into Se Nanoparticles

Xiao,

Li,

Huang

et al. 2023

Molecular Nutrition Food Res

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Selenium (Se) is a momentous metallic element that plays an irreplaceable role in biochemical activities. Se deficiency remains a nutritional challenge across the world. Organic Se supplementation is the most effective treatment means for Se deficiency. Organic Se transformed from Se‐enriched probiotics show outstanding excellent properties in antibacteria, anti‐oxidation, anti‐inflammation, and immunoregulation. Studying the influencing factors for Se enrichment capacity and enrichment mechanisms of Se‐enriched probiotics is conducive to the exploit of more potent Se‐enriched probiotics. Se‐enriched probiotics transform inorganic Se into Se nanoparticles (SeNPs), which have been widely used in animal husbandry and biomedical field. In this paper, the novel development of Se‐enriched probiotics is reviewed, and the bioactivities of SeNPs are assessed, so as to display their potential application prospects. The excellent role of SeNPs in anti‐oxidation is summarized, and the mechanism by which SeNPs improve Se deficiency and boost animal health is explained.

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“…Alternatively, epigenetic mechanisms within developing offspring may also explain developmental programming responses resulting from dietary Se supplementation ( 53 ). Specifically, enzymes associated with one-carbon metabolism have been shown to be affected by Se ( 54 , 55 ), while others ( 56 ) reported that Se regulates microRNAs ( 56 ) and DNA methylation ( 55 , 57 ). In humans experiencing Kashin-Beck disease (associated with Se deficiencies), differentially methylated genes were reported ( 53 ).…”

Section: Selenium Supplementation During Pregnancymentioning

confidence: 99%

Selenium supplementation and pregnancy outcomes

Dahlen

Reynolds²,

Caton³

2022

Front. Nutr.

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In vertebrates and invertebrates, selenium (Se) is an essential micronutrient, and Se deficiency or excess is associated with gonadal insufficiency and gamete dysfunction in both males and females, leading to implantation failure, altered embryonic development and, ultimately, infertility. During pregnancy, Se excess or deficiency is associated with miscarriage, pre-eclampsia (hypertension of pregnancy), gestational diabetes, fetal growth restriction and preterm birth. None of this is surprising, as Se is present in high concentrations in the ovary and testes, and work in animal models has shown that addition of Se to culture media improves embryo development and survival in vitro in association with reduced reactive oxygen species and less DNA damage. Selenium also affects uterine function and conceptus growth and gene expression, again in association with its antioxidant properties. Similarly, Se improves testicular function including sperm count, morphology and motility, and fertility. In animal models, supplementation of Se in the maternal diet during early pregnancy improves fetal substrate supply and alters fetal somatic and organ growth. Supplementation of Se throughout pregnancy in cows and sheep that are receiving an inadequate or excess dietary intake affected maternal whole-body and organ growth and vascular development, and also affected expression of angiogenic factors in maternal and fetal organs. Supplemental Se throughout pregnancy also affected placental growth, which may partly explain its effects on fetal growth and development, and also affected mammary gland development, colostrum yield and composition as well as postnatal development of the offspring. In conclusion, Se supplementation in nutritionally compromised pregnancies can potentially improve fertility and pregnancy outcomes, and thereby improve postnatal growth and development. Future research efforts should examine in more detail and more species the potential benefits of Se supplementation to reproductive processes in mammals.

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Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress

Cited by 10 publications

References 129 publications

Lifestyle-Driven Variations in Nutrimiromic MicroRNA Expression Patterns across and beyond Genders

Lifestyle-Driven Variations in Nutrimiromic MicroRNA Expression Patterns across and beyond Genders

Advances in the Study of Selenium‐Enriched Probiotics: From the Inorganic Se into Se Nanoparticles

Selenium supplementation and pregnancy outcomes

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