Dietary selenium variation-induced oxidative stress modulates CDC2/cyclin B1 expression and apoptosis of germ cells in mice testis

Effects of different levels of dietary selenium on the proliferation of spermatogonial stem cells and antioxidant status in testis of roosters

“…It could be the oxidative stress induced by the Se excess that contributes to the difference in the SSCs population of various Se treatments confirming earlier reports (Kaushal and Bansal, 2007;Ranawat and Bansal, 2009). The interesting finding of this study is that the lower GSH-Px activity and higher MDA content was obtained in the control group when compared with that in the 2.0 mg/kg group.…”

Effects of apocynin on oxidative stress and expression of apoptosis-related genes in testes of diabetic rats

“…There is increasing evidence showing that excessive ROS production triggers an apoptosis cascade through the phosphorylation of JNK and activation of Bax (18), and by activating caspase, regulating the expression of Bcl-2 family proteins (19). Moreover, the decreased production of testosterone may also promote germ cell apoptosis (20).…”

Artesunate enhances radiosensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phase

“…The cyclin B1 level was crucial to determining the levels of cdc2 because cyclin B1 was the regulator of the activity of the cdc2-cyclin B1 complex. The repression of cyclin B1 transcription provided a mechanism for G 2 /M phase arrest in germ cells [24,25]. The results showed irradiation alone had no effect on cyclin B1 mRNA expression but artesunate alone could significantly decrease the expression of the cells.…”