Dietary Sources of Copper

Delves, H. T.

doi:10.1002/9780470720622.ch2

Cited by 5 publications

References 43 publications

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Copper uptake and trafficking in the brain

Crisponi

Nurchi

Gerosa

et al. 2012

Metal Ions in Neurological Systems

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The aim of this chapter is to give a general view on the current status of the scientific basis for the role of copper in human health and disease, outlining the roles of copper in human metabolism and bioenergetics, its coordination chemistry as well as the biological ligands involved in the multiple steps of metal incorporation. In particular, our attention has been focused towards the interaction of copper status and brain function in health and disease, with particular consideration to the role of copper in the pathogenesis of Wilson’s, of Menkes’s, and of human neurodegenerative diseases. Data on interactions between essential trace elements and copper, from the level of absorption in the gut to other systems in the body, are also presented. Particular attention is paid to copper-dependent enzymes in the central nervous system and to copper uptake and trafficking in brain cells

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Copper uptake and trafficking in the brain

Crisponi

Nurchi

Gerosa

et al. 2012

Metal Ions in Neurological Systems

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Transport and storage of metals

Laurie

1983

J of Inher Metab Disea

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Current understanding of the means by which the trace metals copper, iron, and zinc are transported and stored in the human body is reviewed. Although metal-related inherited metabolic diseases manifest themselves as deficiencies in metalloenzymes, these deficiencies in fact arise from disturbances in the absorption/rejection or transport or storage phases of the metal metabolism. The considerable information available on iron metabolism shows these phases to be closely interrelated with a number of feedback mechanisms operating as controls on the various metabolic stages. Copper and zinc have vastly different roles in their enzymes but, following their close coordination chemistry properties, have similar metabolic routes. Both make use of albumin for transport and of metallothionein at the absorption and hepatic-binding stages. In contrast to iron, copper and zinc have no well-defined storage system; instead they make use of body reserves distributed in various tissues. Our knowledge of the transport and storage systems of the trace metals is still very incomplete. More research is needed on the dynamics of movement of the trace metals between the various body tissues and fluids. Further advances will also come from the study of related metal inherited diseases in other animal species.

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