Dietary stilbenes as modulators of specific miRNAs in prostate cancer

Abstract

Accumulated experimental data have suggested that natural plant products may be effective miRNA-modulating chemopreventive and therapeutic agents. Dietary polyphenols such as flavonoids, stilbenes, and lignans, among others, have been intensively studied for their miRNA-mediated cardioprotective, antioxidant, anti-inflammatory and anticancer properties. The aim of this review is to outline known stilbene-regulated miRNAs in cancer, with a special focus on the interplay between various miRNAs and MTA1 signaling in prostate cancer. MTA1 is an epigenetic reader and an oncogenic transcription factor that is overexpressed in advanced prostate cancer and metastasis. Not surprisingly, miRNAs that are linked to MTA1 affect cancer progression and the metastatic potential of cells. Studies led to the identification of MTA1-associated pro-oncogenic miRNAs, which are regulated by stilbenes such as resveratrol and pterostilbene. Specifically, it has been shown that inhibition of the activity of the MTA1 regulated oncogenic miR-17 family of miRNAs, miR-22, and miR-34a by stilbenes leads to inhibition of prostatic hyperplasia and tumor progression in mice and reduction of proliferation, survival and invasion of prostate cancer cells in vitro. Taken together, these findings implicate the use of resveratrol and its analogs as an attractive miRNA-mediated chemopreventive and therapeutic strategy in prostate cancer and the use of circulating miRNAs as potential predictive biomarkers for clinical development.

Pterostilbene alleviates abdominal aortic aneurysm via inhibiting macrophage pyroptosis by activating the miR-146a-5p/TRAF6 axis

“…In addition, PTE possesses various pharmacological activities, including anticancer, antiinflammatory, and antioxidant activities. [41][42][43] We measured intracellular ROS levels in Raw 264.7 macrophages using DCHF as a fluorescent probe. Our results showed that ROS levels were inhibited in the PTE-treated group compared with the LPStreated group (ESI Fig.…”

The Bone Microenvironment Soil in Prostate Cancer Metastasis: An miRNA Approach

“…Metastasis-associated protein 1 (M overexpressed in PCa, especially in bone metastatic lesions, and is related to d expression of E-cadherin through cathepsin B (CTSB), leading cells to EMT [188 was found to be positively associated with MTA1 and contribute to reducing Eexpression [189]. Dietary polyphenols such as flavonoids and stilbenes, i resveratrol, are related to inhibition of miR-22 and the oncogenic MTA1-a miRNAs miR-17 and miR-34a [190,191]. Pterostilbene, along with res downregulates miR-17-5p and miR-106a-5p, miRNAs that target tumor su phosphatase and tensin homolog (PTEN) [192,193].…”

“…miR-22 was found to be positively associated with MTA1 and contribute to reducing E-cadherin expression [ 189 ]. Dietary polyphenols such as flavonoids and stilbenes, including resveratrol, are related to inhibition of miR-22 and the oncogenic MTA1-associated miRNAs miR-17 and miR-34a [ 190 , 191 ]. Pterostilbene, along with resveratrol, downregulates miR-17-5p and miR-106a-5p, miRNAs that target tumor suppressor phosphatase and tensin homolog (PTEN) [ 192 , 193 ].…”

Stilbenes: a promising small molecule modulator for epigenetic regulation in human diseases

“…MTA1 is responsible for deacetylating PTEN, an important tumor suppressor protein, thereby inhibiting its expression. Pterostilbene reduced MTA1-dependent cell survival and metastasis in prostate cancer by inhibiting MTA1 expression, disrupting the MTA1-histone deacetylase complex, and restoring PTEN expression ( Dhar et al, 2016 ; Levenson, 2022a ; Levenson, 2022b ; Kocabas and Sanlier, 2023 ). In hepatocellular carcinoma, Pterostilbene decreased MTA1 expression and HDAC1 activity, disrupting the MTA1/histone deacetylase complex and leading to restored PTEN acetylation and subsequent induction of apoptosis in cancer cells ( Qian et al, 2018 ).…”

“…Examples include Resveratrol (RSV), Pterostilbene (PTE), and their dimers, such as (±)-trans-δ-vinifera ( Giacomini et al, 2016 ; Kluska et al, 2023 ). They function as antioxidants and anticancer agents, modulating epigenetic marks that impact disease progression, particularly in terms of DNA methylation and histone modification ( Ganguly et al, 2021 ; Levenson, 2022a ; Sukocheva et al, 2022 ), which, in turn, can influence gene expression patterns and promote or hinder disease progression.…”