Dietary sucrose, glucose, fructose, and starches affect colonic functions in rats

Caderni, Giovanna; Luceri, Cristina; Lancioni, L.; Dolara, Piero

doi:10.1080/01635589609514440

Cited by 22 publications

(10 citation statements)

References 20 publications

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“…Animal and human studies have shown that manipulation of diet and other lifestyle exposures result in adaptive changes in the colon crypt epithelium and in TGF-α expression specifically (17, 21, 22, 24, 25). Our preliminary findings suggest that TGF-α levels may vary according to modifiable dietary risk factors (intake of sucrose, low-fat dairy, fruits, and vegetables), and although, in this small sample, few differences were statistically significant, many are consistent with current hypotheses about diet, growth, and colorectal cancer (7, 14, 17, 20, 24, 25, 35, 44–48). Furthermore, associations between TGF-α expression and risk for adenoma were strengthened following adjustment for risk factors, suggesting that a person with elevated TGF-α levels could further increase or decrease their probability of being a case (that is, risk for incident sporadic colorectal adenoma) based on their history of risk behaviors, such as use of NSAIDs or total energy intake.…”

Section: Discussionsupporting

confidence: 75%

TGF-α Expression as a Potential Biomarker of Risk Within the Normal-appearing Colorectal Mucosa of Patients with and without Incident Sporadic Adenoma

Daniel¹,

Bostick

Flanders³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Transforming growth factor-A (TGF-A), a stimulatory growth factor and member of the epidermal growth factor family, is a mediator of oncogenesis and malignant progression in colorectal carcinogenesis. Limited evidence suggests its utility as a growth-related biomarker of risk for colorectal cancer. Methods: We measured expression of TGF-A in biopsies of normal-appearing colorectal mucosa using automated immunohistochemistry and quantitative image analysis in a subsample of 29 cases and 31 controls from a colonoscopy-based case-control study (n = 203) of biomarkers of risk for incident sporadic

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Section: Discussionsupporting

confidence: 75%

TGF-α Expression as a Potential Biomarker of Risk Within the Normal-appearing Colorectal Mucosa of Patients with and without Incident Sporadic Adenoma

Daniel¹,

Bostick

Flanders³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Consequently, an elevated dietary level of fructose (460 g kg À1 ) produced a low caecal concentration of SCFA, and of the same magnitude as an identical level of glucose. 39 In the present study, caecal weights for rats fed apples tended to be higher than for the other groups (data not shown), suggesting that some amounts of fructose might have added to the amount of indigestible carbohydrates reaching the rat hindgut. Fructosecontaining oligosaccharides such as Neosugar 11 and inulin 40,41 have been found to give high proportions of butyric acid in the rat caecum.…”

Section: Discussionmentioning

confidence: 75%

Short‐chain fatty acid content in the hindgut of rats fed various composite foods and commercial dietary fibre fractions from similar sources

Henningsson¹,

Nyman²,

Björck³

2002

J Sci Food Agric

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The fermentability of indigestible carbohydrates and content of short-chain fatty acids along the hindgut of rats were investigated using plant materials of importance in the Swedish diet (instant potato powder, apples and oat¯akes). Results with the composite food products were compared with commercial ®bre fractions obtained from similar sources, ie potato ®bre, apple pectin and b-glucanenriched oat ®bre. The materials were incorporated into diets yielding a concentration of 60 or 70 g kg À1 indigestible carbohydrates. The fermentability of indigestible carbohydrates was high with all diets, between 79 and 90%. All substrates except the pure apple pectin generated intermediate to high proportions of butyric acid in the caecum (15±22 vs 8%). The potato products gave high concentrations of butyric acid in the distal colon. The potato powder, ie the diet with the highest content of resistant starch (22 g kg À1 ), also gave the highest proportion of butyric acid in the distal colon (19%), which was higher than the proportion in the caecum with the same substrate (15%) (P < 0.005). The composite foods promoted a higher proportion of butyric acid in the distal colon as compared with the commercial ®bre fractions (P < 0.05).

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“…2000b; Ferguson et al . 2000), reduce faecal and/or caecal pH (Caderni et al . 1996; Cassand et al .…”

Section: Resistant Starch and Colonic Function (Colorectal Cancer Inmentioning

confidence: 99%

Health properties of resistant starch

2005

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Summary Resistant starch (RS) refers to the portion of starch and starch products that resist digestion as they pass through the gastrointestinal tract. RS is an extremely broad and diverse range of materials and a number of different types exist (RS1–4). At present, these are mostly defined according to physical and chemical characteristics. RS may be categorised as a type of dietary fibre, as defined by the American Association of Cereal Chemists and the Food Nutrition Board of the Institute of Medicine of the National Academies. RS is measured in part by the methodology recommended by the Association of Official Analytical Chemists for measuring dietary fibre. Dietary intakes of RS in westernised countries are likely to be low. However, accurate comparative assessments of dietary intakes between countries, and subsequent epidemiological analysis, are absent due to the lack of consensus over of an agreed, repeatable and simple in vitro method for analysing the RS content of foods. At present, the recognised method is that of McCleary & Monaghan (2002). RS appears to confer considerable benefits to human colonic health, but has a smaller impact on lipid and glucose metabolism. Comparisons between studies are hampered by differences in study design, poor experimental design and differences in the source, type and dose of RS in the ingredients or diets used. It is likely that RS mediates some or all of its effects through the action of short chain fatty acids but interest is increasing regarding its prebiotic potential. There is also increasing interest in using RS to lower the energy value and available carbohydrate content of foods. RS can also be used to enhance the fibre content of foods and is under investigation regarding its potential to accelerate the onset of satiation and to lower the glycaemic response. Due to the difficulties in agreeing on a universal definition and method of analysis for dietary fibre, RS may be included within the term ‘fibre’ on the nutrition labels in some countries but not in others. Pressure to agree a legal definition and universal method of analysis is likely to increase due to the potential of RS to enhance colonic health, and to act as a vehicle to increase the total dietary fibre content of foodstuffs, particularly those which are low in energy and/or in total carbohydrate content.

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Dietary sucrose, glucose, fructose, and starches affect colonic functions in rats

Cited by 22 publications

References 20 publications

TGF-α Expression as a Potential Biomarker of Risk Within the Normal-appearing Colorectal Mucosa of Patients with and without Incident Sporadic Adenoma

TGF-α Expression as a Potential Biomarker of Risk Within the Normal-appearing Colorectal Mucosa of Patients with and without Incident Sporadic Adenoma

Short‐chain fatty acid content in the hindgut of rats fed various composite foods and commercial dietary fibre fractions from similar sources

Health properties of resistant starch

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