Dietary Supplementation of Glycyrrhetinic Acid (GA) Promoting Lipid Lipolysis from Blunt Snout Bream Megalobrama amblycephala by TNF-α and LPL Expression

My, Liu; Gx, Liu; Zhou, Mingyue; Wb, Liu; Jiang, Guotai

doi:10.46989/001c.20907

Cited by 3 publications

(2 citation statements)

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“…In this study, the supplementation of 0.02% GL could decrease the mRNA expression of proinflammatory factors ( il-1β and il-6 ) and increase the mRNA expression of anti-inflammatory factor ( il-10 ), which probably due to the higher proportion of GL supplementation could better reflect the anti-inflammatory capacity of GL. Similar results have been confirmed in studies of silver carp [ 24 ], Asian seabass [ 21 ], blunt snout bream [ 22 ], and yellow catfish [ 41 ]. In summary, the supplementation of 0.02% GL could alleviate the inflammation of large yellow croaker larvae.…”

Section: Discussionsupporting

confidence: 83%

“…However, the application of GL in aquatic diets has been rarely reported. Results of the study in white shrimp (Litopenaeus vannamei), Asian seabass (Lateolabrax maculatus), and blunt snout bream (Megalobrama amblycephala) prove that GL could improve the anti-inflammatory capacity [21][22][23]. In particular, Harikrishnan et al found that different dosages of GL could improve the growth, activity of digestive-antioxidant, and innate-adaptive defense of silver carp (Hypophthalmichthys molitrix) [24].…”

Section: Introductionmentioning

confidence: 97%

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Effects of Glycyrrhizin (GL) Supplementation on Survival, Growth Performance, Expression of Feeding-Related Genes, Activities of Digestive Enzymes, Antioxidant Capacity, and Expression of Inflammatory Factors in Large Yellow Croaker (Larimichthys crocea) Larvae

Wang

Zhang

et al. 2022

Aquaculture Nutrition

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A 30-day feeding trial was conducted to determine the effects of dietary glycyrrhizin (GL) on survival, growth performance, expression of feeding-related genes, activities of digestive enzymes, antioxidant capacity, and expression of inflammatory factors of large yellow croaker larvae with an initial weight of 3.78 ± 0.27 mg. Four 53.80% crude protein and 16.40% crude lipid diets were formulated with supplementation of 0%, 0.005%, 0.01%, and 0.02% GL, respectively. Results indicated that larvae fed diets with GL had higher survival rate and specific growth rate than the control ( P < 0.05 ). Compared with the control, the mRNA expression of orexigenic factor genes including neuropeptide Y (npy) and agouti-related protein (agrp) were significantly increased in larvae fed the diet with 0.005% GL, while the mRNA expression of anorexigenic factor genes including thyrotropin-releasing hormone (trh), cocaine and amphetamine regulated transcript (cart), and leptin receptor (lepr) were significantly decreased in larvae fed the diet with 0.005% GL ( P < 0.05 ). The trypsin activity in larvae fed the diet with 0.005% GL was significantly higher than the control ( P < 0.05 ). The alkaline phosphatase (AKP) activity in larvae fed the diet with 0.01% GL was significantly higher than the control ( P < 0.05 ). A clear increase of total glutathione (T-GSH) content, activities of superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) was observed in larvae fed the diet with 0.01% GL compared with the control ( P < 0.05 ). Moreover, the mRNA expression of interleukin-1β (il-1β) and interleukin-6 (il-6) (proinflammatory genes) in larvae fed the diet with 0.02% GL were significantly lower than the control ( P < 0.05 ). In conclusion, the supplementation of 0.005% -0.01% GL could enhance the expression of orexigenic factor genes, activities of digestive enzymes and antioxidant capacity, ultimately improving the survival, and growth performance of large yellow croaker larvae.

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