Dietary supplementation of plant essential oil improves growth performance, intestinal morphology and health in weaned pigs

Su, Guoqi; Zhou, Xuanwu; Wang, Yu; Chen, Shuai; Chen, Guang; Li, Yan; He, Jun

doi:10.1111/jpn.13271

Cited by 25 publications

(16 citation statements)

References 47 publications

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“…Overall, the groups that received OCE, MOCE, and MOC showed lower Cd, higher Vh, and higher Vh : Cd than the control group. At the same time, IAA values were numerically higher in all treated groups compared to the control group; nevertheless, statistical significance was only achieved in the ileum samples from group C. The improvement of intestinal histomorphology associated with the incorporation of different phytogenic compounds including thymol, carvacrol, and eugenol in the swine diet has been described several times 28 , 29 .…”

Section: Discussionmentioning

confidence: 99%

“…In our study, disaccharidases activity showed higher values in samples from treated than from control groups, though statistically significant differences were only observed for the group receiving MOCE. The increase of digestive enzymes activity in animals fed diets supplemented with phytogenic compounds has been described in poultry 28 , 30 and pigs 3 , 29 . In our work, a higher enzymatic activity was accompanied by a higher Vh : Cd.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Dietary Oregano (Lippia origanoides) and Clover (Eugenia caryophillata) Essential Oilsʼ Formulations on Intestinal Health and Performance of Pigs

et al. 2021

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The incorporation of natural essential oils to the pigsʼ diet in intensive production systems is a potential tool to improve gut health and prevent infections without using antibiotics. Nevertheless, different products, even containing the same compounds, coming from the same botanical species, may exert dissimilar biological effects due differences in the technological processes by which they are produced and preserved. For this reason, suitability of a given product based on natural extracts, intended for swine production must be thoroughly evaluated. In the present study, we assessed the effects of three additives containing oregano (Lippia origanoides) essential oil, alone or in combination with clover (Eugenia caryophillata) essential oil, with or without being microencapsulated, on gastrointestinal health and on some performance parameters in a commercial pig production farm. Recently weaned piglets were randomly divided in four groups, and basal diet or essential oil-supplemented diet (OCE; MOCE; MOE) was randomly assigned to each of the groups from weaning to finishing. Blood samples were collected at pre-established days after weaning. Intestinal sampling took place at 42 and 72 days of age. Pigs consuming the supplemented diets showed higher intestinal metabolic activity during the post-weaning period, decreasing the impact of weaning stress on enterocytesʼ metabolism. Intestinal barrier function was not affected in pigs consuming microencapsulated products. All treated groups showed improved intestinal architecture, increased digestive enzymes activity and caecal VFA concentrations. The incorporation of the dietary essential oils products brought beneficial effects on gastrointestinal health that were reflected in improved performance parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Oregano (Lippia origanoides) and Clover (Eugenia caryophillata) Essential Oilsʼ Formulations on Intestinal Health and Performance of Pigs

et al. 2021

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“…Wang et al ( 36 ) found that orange EO could regulate the intestinal microbiota of mice by increasing the relative abundance of Lactobacillus and reducing the presence of bacteria producing short chain fatty acids. EOs with the active ingredient of 13.5% thymol and 4.5% cinnamaldehyde markedly up-regulated the expression levels of occludin in the duodenum, which suggested that EOs maintained the integrity of intestinal barrier ( 37 ). Zou et al ( 38 ) found that pretreatment with oregano EO could significantly decrease the expression of occludin and ZO-1 in porcine epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Lemon Essential Oil and Its Major Active Component, D-Limonene, on Intestinal Injury and Inflammation of E. coli-Challenged Mice

et al. 2022

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Inflammatory diseases are a major threat to public health. Natural plant essential oils (EOs) possess anti-inflammatory and anti-oxidative activities. The objective of this study was to investigate the anti-inflammatory effect and mode of action of lemon essential oil (LEO), and its main active component, d-limonene, with different doses on intestinal inflammation of mice. Sixty-four 5-week-old male balb/c mice weighing 22.0 ± 1.5 g were randomly assigned into one of 8 treatments (n = 8/treatment), including normal saline group (NS), Escherichia coli (E. coli) group, and either LEO and d-limonene essential oil (DEO) group supplemented at 300, 600, and 1,200 mg/kg of BW, respectively. After the pre-feeding period, the mice were fasted for 12 h, the mice in the NS group and the E. coli group were gavaged with normal saline, and the mice in the LEO group and DEO group were gavaged with respective dose of EOs for 1 week. One hour after the end of gavage on the 7th day, except that the mice in the normal saline group were intraperitoneally injected with normal saline, the mice in the other groups were intraperitoneally injected with the same concentration of E. coli (108 cfu/ml, 0.15 ml per mouse). The antioxidant indexes were measured including superoxide dismutase (SOD), malondialdehyde (MDA), and myeloperoxidase (MPO) in plasma obtained by taking blood from mouse eyeballs. The inflammatory indexes were measured including interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor alpha (TNF-α) in plasma. The tight junction protein indicators were tested include zona occludens 1 protein (ZO-1), occludin and claudin in mouse duodenum. We found that all of the above indexes for E. coli group were different (P< 0.05) with the NS group. The interaction of EO and dose (E × D) were significant (P < 0.01) for all of the indexes. In addition, LEO at 300 mg/kg BW and DEO at 600 mg/kg BW had better antioxidant and anti-inflammation activity on the infected mice, which reduced (P < 0.05) the plasma concentrations of MDA, MPO, TNF-α, IL-1β, and IL-6, but increased (P < 0.01) the concentrations of SOD. Hematoxylin-eosin (H&E) staining of duodenum observation showed that LEO and DEO reduced inflammatory cell infiltration and maintain the orderly arrangement of epithelial cells. Moreover, supplementation of LEO at 600 mg/kg and DEO at 300 mg/kg BW alleviated (P < 0.05) intestinal barrier injury for increasing the relative expression of ZO-1, occludin and claudin mRNA in mice duodenum. These results showed that the pre-treatment with LEO and DEO had protection of intestinal tissue and inflammation in E. coli infected mice. Both LEO and DEO exhibited activity of antioxidant, anti-inflammatory and alleviating intestinal injury, whereas, compared with DEO, LEO can be active at a lower dosage. Furthermore, as the main active component of LEO, the d-limonene appeared to play not only the major role, but also the joint action with other active components of LEO.

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“…The vacuum tubes of EDTA-Na 2 were immediately placed on ice for analysis of blood biochemistry. Blood samples with sodium heparin were centrifuged (3000g, 15 min, 4°C) to obtain plasma samples, and stored at −80°C for further analysis (Su et al 2020).…”

Section: Blood Samplementioning

confidence: 99%

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et al. 2022

Anim. Prod. Sci.

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Context. In-feed antibiotics are commonly used to improve growth and gut health of weaning pigs. Due to anti-microbial resistance by extensively using antibiotics, however, in-feed antibiotics have been banned in Europe and China. Tremella fuciformis is a traditional edible fungus in China. Recent studies have found that Tremella fuciformis extract (TFE) has anti-inflammatory, anti-cancer and immune-modulatory functions. Therefore, there is the potential to develop Tremella fuciformis as an alternative to antibiotics. Aims. The study was performed to explore the effects of TFE on growth performance, and biochemical and immunological parameters of weaned piglets under lipopolysaccharide (LPS) challenge. Methods. Forty-eight weaned piglets were assigned into two groups with six pens (four piglets per-pen), receiving a control diet or a control diet with 400 mg/kg TFE (TFE), respectively. After 28 days of the trial, two piglets per pen were selected to be injected with LPS (50 μg/kg of BW) or an equivalent amount of sterile saline. Blood samples were collected at 0 and 3 h after LPS challenge. Key results. The results showed that TFE supplementation significantly increased the average daily gain (P < 0.05) and decreased the faecal score (P < 0.05) during the first week, improved the feed conversion ratio (P < 0.05) and BWt gain (P < 0.05) during the whole period. Piglets fed the TFE diet had higher plasma levels of white blood cells (P < 0.05) than that of piglets fed the control diet diet before the LPS challenge. Regardless of the dietary treatment, the LPS challenge significantly decreased the level of white blood cells, and increased the levels of red blood cells, haemoglobin, haematocrit, total protein, interleukin-1β and tumour necrosis factor-α (all P < 0.05). Regardless of the LPS challenge, however, the concentrations of total protein, interleukin-1β and tumour necrosis factor-α were decreased (all P < 0.05) in the plasma of piglets fed the TFE diet compared with the control diet diet. Conclusions. In summary, the supplementation of TFE in the weaning diet could improve the growth performance and immunity of piglets. Implication. TFE could be used as a bioactive substance for improving growth and immune response in pig production.

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Dietary supplementation of plant essential oil improves growth performance, intestinal morphology and health in weaned pigs

Cited by 25 publications

References 47 publications

Effect of Dietary Oregano (Lippia origanoides) and Clover (Eugenia caryophillata) Essential Oilsʼ Formulations on Intestinal Health and Performance of Pigs

Effect of Dietary Oregano (Lippia origanoides) and Clover (Eugenia caryophillata) Essential Oilsʼ Formulations on Intestinal Health and Performance of Pigs

Protective Effect of Lemon Essential Oil and Its Major Active Component, D-Limonene, on Intestinal Injury and Inflammation of E. coli-Challenged Mice

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