Dietary supplementation of total flavonoids from Rhizoma Drynariae improves bone health in older caged laying hens

Huang, Jiu; Tong, Xili; Yu, Zilin; Yanping, Hu; L, Zhang; Liu, Y; Zhou, Zhongxin

doi:10.1016/j.psj.2020.06.057

Cited by 16 publications

(9 citation statements)

References 47 publications

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“…In hens, the concentration of serum OCN significantly decreases with age [ 31 , 32 ], from 200–300 ng/mL at 6-week-old to 150 ng/mL at 16-week-old, then below 50 ng/mL after hens starting to lay eggs [ 24 , 33 , 34 ]. There is a difference in circulating total OCN concentration between adult hens and mice (about 300 ng/mL in mice), which may reveal some species-specific functions of OCN during sexual maturity in chickens, but this field needs more research [ 35 ].…”

Section: Osteocalcinmentioning

confidence: 99%

“…Laying hens with keel bone damage [ 57 ] or fed a low phosphorus diet [ 58 ] have elevated serum OCN levels, which leads to an imbalance of bone homeostasis. On the contrary, the decreased its serum levels are related to bone health in older caged laying hens [ 33 ]. Generally, the functions of ucOCN in chickens are mainly concentrated on bone metabolism [ 57 , 58 ].…”

Section: Osteocalcinmentioning

confidence: 99%

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Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

Zhang

Jiang

et al. 2023

Animals

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Osteocalcin (OCN) is synthesized and secreted by differentiating osteoblasts. In addition to its role in bone, OCN acts as a hormone in the pancreas, liver, muscle, fat, and other organs to regulate multiple pathophysiological processes including glucose homeostasis and adipic acid metabolism. Fat metabolic disorder, such as excessive fat buildup, is related to non-alcoholic fatty liver disease (NAFLD) in humans. Similarly, fatty liver hemorrhage syndrome (FLHS) is a metabolic disease in laying hens, resulting from lipid accumulation in hepatocytes. FLHS affects hen health with significant impact on poultry egg production. Many studies have proposed that OCN has protective function in mammalian NAFLD, but its function in chicken FLHS and related mechanism have not been completely clarified. Recently, we have revealed that OCN prevents laying hens from FLHS through regulating the JNK pathway, and some pathways related to the disease progression have been identified through both in vivo and vitro investigations. In this view, we discussed the current findings for predicting the strategy for using OCN to prevent or reduce FLHS impact on poultry production.

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Section: Osteocalcinmentioning

confidence: 99%

Section: Osteocalcinmentioning

confidence: 99%

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

Zhang

Jiang

et al. 2023

Animals

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“…N). The preparation and staining methods of bone tissue sections were described by Huang et al (2020b). First, total tissue area (T. Ar) of cancellous bone, trabecular bone area (Tb.…”

Section: Bone Histomorphometrymentioning

confidence: 99%

Icariin protects against cage layer osteoporosis by intervening in steroid biosynthesis and glycerophospholipid metabolism

Huang

Zhou

2021

Animal Diseases

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Cage layer osteoporosis (CLO) is a common bone metabolism disease in the breeding industry of China. However, effective prevention for CLO has not been developed. Icariin (ICA), the main bioactive component of the Chinese herb Epimedium, has been shown to have good therapeutic effects on bone-related diseases. In this study, the effects of ICA were further evaluated in a low-calcium diet-induced CLO, and a serum metabolomics assay was performed to understand the underlying mechanisms. A total of 144 31-wk-old Lohmann pink-shell laying hens were randomly allocated to 4 groups with 6 replicates of 6 hens per replicate. The 4 dietary treatment groups consisted of a basal diet (3.5% calcium), a low-calcium diet (2.0% calcium), and a low-calcium diet supplemented with 0.5 or 2.0 g/kg ICA. The results showed that ICA exerted good osteoprotective effects on low-calcium diet-induced CLO. ICA significantly increased femur bone mineral density, improved bone microstructure, decreased bone metabolic level, and upregulated mRNA expression of bone formation genes in femoral bone tissue. Serum untargeted metabolomics analysis showed that 8 metabolite levels were significantly changed after ICA treatment, including increased contents of 7-dehydrocholesterol, 7-oxocholesterol, desmosterol, PC (18:1(9Z)/18:1(9Z)), PS (18:0/18:1(9Z)), N,N-dimethylaniline and 2-hydroxy-butanoic acid and decreased N2,N2-dimethylguanosine. Metabolic pathway analysis based on the above 8 metabolites indicated that ICA mainly perturbed steroid biosynthesis and glycerophospholipid metabolism. These findings suggest that ICA can effectively prevent bone loss in low-calcium diet-induced CLO by mediating steroid biosynthesis and glycerophospholipid metabolism and provide new information for the regulation of bone metabolic diseases.

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“…Moreover, natural products from herbal plants are also applied in the poultry industry. For example, dietary supplementation total flavonoids from Rhizoma Drynariae and icariin from Epimedium can increase egg weight and improve bone tissue microstructure of hens ( Huang et al, 2020a , b ). Moreover, in the livestock industry, dietary supplementation Astragalus membranaceus can regulate body antioxidant and immunity of sheep by increasing the concentration of serum interleukin and immunoglobulin ( Wang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation Eucommia ulmoides extract at high content served as a feed additive in the hens industry

et al. 2022

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Since numerous natural components in Eucommia ulmoides belong to phytoestrogen, its effect on hens production deserve more attention. To investigate the potential of E. ulmoides extract used as a feed additive, laying performance, egg quality, yolk cholesterol, yolk fatty acids, yolk fatty, yolk volatile components, albumen amino acids, plasma biochemical parameters, intestinal histology, and gut microbiota of hens (n = 120) were determined between basal diet ( A ) and dietary supplementation low ( B ), middle ( C ), and high ( D ) level E. ulmoides extract for 11 wk. When compared to A group, 2 percentage points elevation in laying rate was observed of D group. Significant up-regulation of immunoglobulin indexes and down-regulation of lipid related indexes in D group were also found if comparison with A group, suggesting that supplementation E. ulmoides extract at a relative high content benefited in immunity enhancing and blood-fat depressing. Meanwhile, obvious variation in albumen amino acids and yolk volatile compounds were inspected as dietary supplementation E. ulmoides extract, especially in D group, implied that the flavor of egg would change under high-level E. ulmoides extract treatment. Besides, villus height and villus height to crypt depth ratio of duodenum, jejunum, and ileum in D group were also significantly higher than that of in A group, indicating high-level E. ulmoides extract contributed to nutrient adsorption via intestinal histology changing. Moreover, the richness, diversity, and composition of gut microbiota in D group also significantly altered with a comparison of A group. These variation caused gut microbiota in D group major enriched in the KEGG pathway of insulin signing pathway, systemic lupus erythematosus, and bacterial invasion of epithelial cells, which were conducive to egg production elevation via facilitating nutrient adsorption, inflammation relieving, blood lipid amelioration, and insulin resistance alleviation. These results indicated that dietary supplementation E. ulmoides extract at high content could serve as a feed additive in the hens industry.

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Dietary supplementation of total flavonoids from Rhizoma Drynariae improves bone health in older caged laying hens

Cited by 16 publications

References 47 publications

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

Icariin protects against cage layer osteoporosis by intervening in steroid biosynthesis and glycerophospholipid metabolism

Dietary supplementation Eucommia ulmoides extract at high content served as a feed additive in the hens industry

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