Dietary supplementation with 25-hydroxycholecalciferol and phytase in growing-finishing pigs: I. Effects on performance, carcass traits, muscle antioxidant capacity and fatty acid profile

Zhang, L.H.; Liu, H.S.; Liu, S.J.; Piao, Xiangshu

doi:10.1016/j.anifeedsci.2021.115003

Cited by 4 publications

(4 citation statements)

References 46 publications

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“…These essential fatty acids could lower triglycerides concentration, stabilize membrane structure, and they are believed to have antithrombotic, anti-inflammatory, and antiarrhythmic properties [ 22 ]. High n-6/n-3 pushes the pathogenesis of several diseases, such as autoimmune disease, osteoporosis, and cardiovascular disease, but lower n-6/n-3 (or higher n-3 PUFA) exerts suppressive effects on the above diseases [ 23 ]. Several fatty acids, including C22:6 n-3, C18:1 n-9c, and C18:3 n-3, are considered flavor precursors, and their contents can be responsible for the rich aroma of animal-derived foods [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Rosemary extract improves egg quality by altering gut barrier function, intestinal microbiota and oviductal gene expressions in late-phase laying hens

Zhang,

Ge,

Gao

et al. 2023

J Animal Sci Biotechnol

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Background Rosemary extract (RE) has been reported to exert antioxidant property. However, the application of RE in late-phase laying hens on egg quality, intestinal barrier and microbiota, and oviductal function has not been systematically studied. This study was investigated to detect the potential effects of RE on performance, egg quality, serum parameters, intestinal heath, cecal microbiota and metabolism, and oviductal gene expressions in late-phase laying hens. A total of 210 65-week-old “Jing Tint 6” laying hens were randomly allocated into five treatments with six replicates and seven birds per replicate and fed basal diet (CON) or basal diet supplemented with chlortetracycline at 50 mg/kg (CTC) or RE at 50 mg/kg (RE50), 100 mg/kg (RE100), and 200 mg/kg (RE200). Results Our results showed that RE200 improved (P < 0.05) Haugh unit and n-6/n-3 of egg yolk, serum superoxide dismutase (SOD) compared with CON. No significant differences were observed for Haugh unit and n-6/n-3 of egg yolk among CTC, RE50, RE100 and RE200 groups. Compared with CTC and RE50 groups, RE200 increased serum SOD activity on d 28 and 56. Compared with CON, RE supplementation decreased (P < 0.05) total cholesterol (TC) level. CTC, RE100 and RE200 decreased (P < 0.05) serum interleukin-6 (IL-6) content compared with CON. CTC and RE200 increased jejunal mRNA expression of ZO-1 and Occludin compared with CON. The biomarkers of cecal microbiota and metabolite induced by RE 200, including Firmicutes, Eisenbergiella, Paraprevotella, Papillibacter, and butyrate, were closely associated with Haugh unit, n-6/n-3, SOD, IL-6, and TC. PICRUSt2 analysis indicated that RE altered carbohydrate and amino acid metabolism of cecal microbiota and increased butyrate synthesizing enzymes, including 3-oxoacid CoA-transferase and butyrate-acetoacetate CoA-transferase. Moreover, transcriptomic analysis revealed that RE200 improved gene expressions and functional pathways related to immunity and albumen formation in the oviductal magnum. Conclusions Dietary supplementation with 200 mg/kg RE could increase egg quality of late-phase laying hens via modulating intestinal barrier, cecal microbiota and metabolism, and oviductal function. Overall, RE could be used as a promising feed additive to improve egg quality of laying hens at late stage of production. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Rosemary extract improves egg quality by altering gut barrier function, intestinal microbiota and oviductal gene expressions in late-phase laying hens

Zhang,

Ge,

Gao

et al. 2023

J Animal Sci Biotechnol

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“…On day 88, one barrow close to the average BW of each pen was humanly slaughtered after electrical stunning ( Zhang et al, 2021b ). The collecting methods of tissue samples refer to Zhang et al (2021a , b) . Immediately after death, mucosal samples were scraped from the middle parts of the duodenum, jejunum and ileum and stored at −80°C for analysis of antioxidant parameters.…”

Section: Methodsmentioning

confidence: 99%

“…Sufficient P must be provided in cereal-based diets to support the growth and development of pigs. However, pigs lack endogenous phytase in the digestive tract to hydrolyze phytate, resulting in low dietary P digestibility ( Zhang et al, 2021a ). Therefore, farmers usually add inorganic phosphate to feed to meet the P requirements of monogastric animals.…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, inorganic phosphate is a non-renewable resource that is estimated to be depleted in 100–200 years at the current rate of exploitation ( Lautrou et al, 2021 ). Moreover, the unreasonable use of exogenous P led to the enrichment of P in the surrounding environment, resulting in harmful algal blooms and decreased biological diversity ( Zhang et al, 2021a ). In turn, this issue can threaten the sustainable development of the pig industry.…”

Section: Introductionmentioning

confidence: 99%

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Dietary 25-hydroxycholecalciferol modulates gut microbiota and improves the growth, meat quality, and antioxidant status of growing-finishing pigs

Zhang

Long²,

Wang³

et al. 2023

Front. Microbiol.

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Introduction25-Hydroxycholecalciferol (25OHD3) is the active metabolite of regular vitamin D3in vivo, which has a stronger biological activity and is more easily absorbed by the intestine than regular vitamin D3. Our study aimed to detect the potential influences of 25OHD3 on pork quality, antioxidant status, and intestinal microbiota of growing-finishing pigs receiving low-phosphorus (P) diet.Methods and resultsForty pigs [initial body weight (BW): 49.42 ± 4.01 kg] were allocated into two groups including low-P diet (CON group) and low-P diet supplemented with 50 μg/kg 25OHD3 (25OHD3 group). The whole experiment lasted for 88 days, including phase 1 (day 1–28), phase 2 (day 29–60), and phase 3 (day 61–88). The results showed that 25OHD3 supplementation tended to decrease feed conversion ratio in phase 3 and overall phase in comparison with the CON group. 25OHD3 increased (p < 0.05) serum contents of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and decreased (p < 0.05) serum bone-specific alkaline phosphatase level. 25OHD3 increased (p < 0.05) mucosal GSH-Px activity in the duodenum and ileum, and tended to increase redness value and the activities of total antioxidant capacity and SOD in longissimus dorsi. 25OHD3 significantly upregulated the mRNA level of copper/zinc superoxide dismutase, and tended to change the mRNA levels of nuclear factor E2-related factor 2 and kelch-like ECH-associated protein 1 in longissimus dorsi. Moreover, 25OHD3 supplementation decreased (p < 0.05) n-6/n-3 and iodine value in longissimus dorsi. For bone quality, 25OHD3 supplementation increased (p < 0.05) calcium content, bone mineral content, and breaking strength in the metacarpal bones. Moreover, the colonic abundance of Lactobacillus was significantly higher in pigs fed with 25OHD3, and exhibited a positive association with serum antioxidant status, pork quality, and bone characteristics.ConclusionOverall, the inclusion of 25OHD3 in low P diet partly improved production performance, meat quality, antioxidant capacity, bone properties, and gut microbiota composition of growing-finishing pigs.

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Rosemary leaf powder improves egg quality, antioxidant status, gut barrier function, and cecal microbiota and metabolites of late-phase laying hens

Zhang,

Ge,

Gao

et al. 2024

Animal Nutrition

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Dietary supplementation with 25-hydroxycholecalciferol and phytase in growing-finishing pigs: I. Effects on performance, carcass traits, muscle antioxidant capacity and fatty acid profile

Cited by 4 publications

References 46 publications

Rosemary extract improves egg quality by altering gut barrier function, intestinal microbiota and oviductal gene expressions in late-phase laying hens

Rosemary extract improves egg quality by altering gut barrier function, intestinal microbiota and oviductal gene expressions in late-phase laying hens

Dietary 25-hydroxycholecalciferol modulates gut microbiota and improves the growth, meat quality, and antioxidant status of growing-finishing pigs

Rosemary leaf powder improves egg quality, antioxidant status, gut barrier function, and cecal microbiota and metabolites of late-phase laying hens

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