Dietary supplementation with 5-aminolevulinic acid modulates growth performance and inflammatory responses in broiler chickens

Sato, Kei; Matsushita, K.; Takahashi, Kyoko; Aoki, Michiru; Fuziwara, J.L.; Miyanari, Setsuko; Kamada, Toshihiko

doi:10.3382/ps.2010-01201

Cited by 26 publications

(32 citation statements)

References 16 publications

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“…5-Aminolevulinic acid (5-ALA) is a precursor of heme and has some positive effects on health, such as promoting hair growth and boosting the immune system. (1)(2)(3) 5-ALA is also utilized in photodynamic therapy (PDT). ALA-PDT is a combination therapy utilizing appropriate irradiation and a photosensitizer (protoporphyrin IX: PpIX) that is produced from 5-ALA. (4) In recent years, this photochemical property has been used to diagnose brain tumours and determine the area of resection.…”

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confidence: 99%

5-Aminolevulinic acid induced apoptosis via oxidative stress in normal gastric epithelial cells

Ito

Kurokawa

Suzuki

et al. 2019

J. Clin. Biochem. Nutr.

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5 Aminolevulinic acid, a precursor of heme, is utilized in a variety of applications including cancer treatment, surgery, and plant nutrition. However, 5 aminolevulinic acid itself induces oxidative stress and subsequent lipid peroxidation. Reactive oxygen species are factors in oxidative stress, not only causing cellular injury but also inducing several signal transduction pathways. Especially in cancer cells, a significant amount of signalling activation and sub sequent activation of protein is caused by the enhancement of reactive oxygen species production. Reactive oxygen species levels in normal cells are low and an oxidative condition is harmful; hence, administration of 5 aminolevulinic acid to normal cells may induce oxidative stress, resulting in cell death. In this study, we investigated the effect of 5 aminolevulinic acid on normal and cancer cells with regard to oxidative stress. We used the rat normal gastric cell line RGM and its cancer like mutant cell line RGK. 5 Aminolevulinic acid treatment of RGM cells enhanced reac tive oxygen species generation and induced apoptosis associated with p53, whereas RGK cells were unaffected. In addition, RGM cell viability was recovered by application of N acetyl L cysteine or p53 inhibitor. These results suggest that 5 aminolevulinic acid causes oxidative stress in normal gastric cells and induces apoptosis via the p53 dependent pathway.

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confidence: 99%

5-Aminolevulinic acid induced apoptosis via oxidative stress in normal gastric epithelial cells

Ito

Kurokawa

Suzuki

et al. 2019

J. Clin. Biochem. Nutr.

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“…In addition, the inflammatory response resulting from Escherichia coli lipoploysaccharide‐induced immune stimulation was improved in the chickens fed 5‐aminoleevulinic acid (5‐ALA)‐supplemented diets, resulting in improvements in performance (Sato et al . ). Further investigation on nutritional modification of immune developments and responses in broiler chicks may improve production efficiency under stressful raising conditions.…”

Section: Improvement Of Immune Functionmentioning

confidence: 97%

Molecular nutrition: Interaction of nutrients, gene regulations and performances

Sato

2016

Animal Science Journal

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Nutrition deals with ingestion of foods, digestion, absorption, transport of nutrients, intermediary metabolism, underlying anabolism and catabolism, and excretion of unabsorbed nutrients and metabolites. In addition, nutrition interacts with gene expressions, which are involved in the regulation of animal performances. Our laboratory is concerned with the improvement of animal productions, such as milks, meats and eggs, with molecular nutritional aspects. The present review shows overviews on the nutritional regulation of metabolism, physiological functions and gene expressions to improve animal production in chickens and dairy cows.

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“…Several studies of vertebrates and vertebrate cell lines support the hypothesis that exogenous 5‐ALA enhances haem synthesis and activity of haemoproteins: 5‐ALA administration (a) increased intracellular haem levels, increasing the activity of cytochrome P450 in vitro (Miura et al., ); (b) increased the activity of cytochrome c oxidase of the electron transport chain and raised ATP levels in mouse liver (Ogura et al., ); (c) enhanced protein expression of mitochondrial complexes III–V in mouse adipose tissue (Ota et al., ); (d) induced REV‐ERBα expression (Yamashita et al., ); and (e) induced both protein and mRNA expression of haem oxygenase‐1 (HO‐1) (a rate‐limiting enzyme in haem degradation) (Nishio et al., : Ito et al., ). 5‐aminolevulinic acid was also reported to enhance the immune response in chickens (Sato et al., ) and pigs (Chen et al., ) and improves growth performance in eels (Yasumoto, Miyanari, Yoshimura, Kondo & Takahashi, ) (although there is some disagreement on the effect of 5‐ALA on growth; see below).…”

Section: Introductionmentioning

confidence: 99%

“…and (e) induced both protein and mRNA expression of haem oxygenase-1 (HO-1) (a rate-limiting enzyme in haem degradation) (Nishio et al, 2014: Ito et al, 2018. 5-aminolevulinic acid was also reported to enhance the immune response in chickens (Sato et al, 2012) and pigs (Chen et al, 2008) and improves growth performance in eels (Yasumoto, Miyanari, Yoshimura, Kondo & Takahashi, 2012) (although there is some disagreement on the effect of 5-ALA on growth; see below).…”

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Dietary 5-aminolevulinic acid enhances adenosine triphosphate production, ecdysis and immune response in Pacific white shrimp, Litopenaeus vannamei (Boone)

2019

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Previous studies have shown that 5‐aminolevulinic acid (5‐ALA), a precursor of haem, can enhance haem synthesis and the activity of haemoproteins. Here, we investigated the effects of dietary 5‐ALA on Pacific white shrimp, Litopenaeus vannamei (Boone). Dietary groups included basal diet (BD, control) and BD plus 15, 30 and 60 ppm 5‐ALA (ALA15, ALA30 and ALA60 respectively). Hepatopancreas adenosine triphosphate (ATP) levels increased with increasing 5‐ALA concentration (ALA60 p < 0.05) after 2 weeks of feeding. 5‐aminolevulinic acid diets significantly increased the expression of ecdysis‐related genes: nuclear receptor E75 and chitinase 4 (ALA15, ALA30, ALA60), cytochrome P450 Shade (ALA60), chitinase 1 (ALA60) and chitinase 3 (ALA15, ALA60). Catalase (CAT) and prophenoloxidase gene expression levels were also significantly higher in ALA60 after 12 weeks of feeding. Six hours after L. vannamei were exposed to Vibrio parahaemolyticus, total haemocyte count (ALA60) and gene expression levels of CAT (ALA30, ALA60) were significantly higher in 5‐ALA groups compared to the control. 5‐aminolevulinic acid diets also increased survival of L. vannamei following V. parahaemolyticus immersion challenge. These results suggest that supplementing L. vannamei diets with 5‐ALA can enhance ATP production, immune response against V. parahaemolyticus, total haemocyte count and expression of some immune‐related genes. 5‐aminolevulinic acid can also induce ecdysis‐related gene expressions, without adversely affecting growth.

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Dietary supplementation with 5-aminolevulinic acid modulates growth performance and inflammatory responses in broiler chickens

Cited by 26 publications

References 16 publications

5-Aminolevulinic acid induced apoptosis via oxidative stress in normal gastric epithelial cells

5-Aminolevulinic acid induced apoptosis via oxidative stress in normal gastric epithelial cells

Molecular nutrition: Interaction of nutrients, gene regulations and performances

Dietary 5-aminolevulinic acid enhances adenosine triphosphate production, ecdysis and immune response in Pacific white shrimp, Litopenaeus vannamei (Boone)

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