Dietary Supplementation with a Combination of Lactoferrin, Fish Oil, and Enterococcus faecium WB2000 for Treating Dry Eye: A Rat Model and Human Clinical Study

Kawashima, Motoko; Nakamura, Shigeru; Izuta, Yusuke; Inoue, Sachiko; Tsubota, Kazuo

doi:10.1016/j.jtos.2015.12.005

Cited by 52 publications

(33 citation statements)

References 21 publications

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“…The Osaka study, which comprised a cross-sectional investigation of dry eye among office workers, found several new systemic health factors associated with dry eye disease, such as metabolic syndrome, low exercise habit, sedentary lifestyle and poor sleep quality. The results showed that a high level of physical activity was associated with a low risk of dry eye and that sedentary behavior was a risk factor [44]. Animal work also suggests that excess oxidative stress is systemically associated with lacrimal dysfunction [45] and calorie restriction maintains tear secretion and reduces oxidative stress [46].…”

Section: Discussionmentioning

confidence: 99%

Associations between the menstrual cycle, lifestyle factors and clinical assessment of the ocular surface: a prospective observational study

et al. 2020

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Background:Little is known about the ocular surface changes over the menstrual cycle in young women and the interactions with lifestyle factors. Therefore, the purpose of this study was to explore the associations between modifiable lifestyle factors and menstrual cycle phases on the ocular signs and symptoms of dry eye in young healthy women. Methods: This was a prospective 1-month observational study. Thirty young healthy women with regular, 24 to 32day menstrual cycles were recruited. Participants attended three visits at day 7, 14, and 21 (± 1) of their menstrual cycle. At baseline, general health questionnaire was conducted. At each visit, symptomology was quantified using Ocular Surface Disease Index (OSDI) and overall ocular comfort (OOC, visual analogue scale). Ocular signs were assessed using Efron scales, tear break-up time (TBUT) and phenol red thread (PRT). Pearson's correlation was used to determine associations between variables at each visit. Results: A total of 26 participants (mean age = 22.3 ± 3.7 years) with an average menstrual cycle of 28.3 ± 1.3 days completed the 3 visits. The interaction between signs/symptoms and lifestyle factors changed over the cycle. At the follicular phase (day 7), lifestyle factors such diet and levels of stress were correlated with PRT and OSDI, (r = − 0.4, p = 0.022; r = 0.4, p = 0.045 respectively). At the ovulation phase (day 14), the general health score was correlated with OOC scores (r = 0.4, p = 0.047). At day 14, exercise frequency correlated with PRT (r = − 0.4, p = 0.028) and caffeine intake was positively correlate with both; TBUT (r = 0.5, p = 0.020) and PRT (r = 0.5, p = 0.014). At the luteal phase (day 21), we found no correlations between lifestyle factors and dry eye signs or symptoms. Conclusions: The associations between lifestyle factors and objective and subjective ocular surface assessment appeared to be more pronounced during the ovulation phase of the menstrual cycle compared to the follicular and luteal phases. Misalignment of these factors with the ocular health during the luteal phase could be attributed to central sensitization and changes in levels of luteinising hormone. Natural hormonal changes during menstrual cycle should be considered for diagnosis and treatment of dry eye in young healthy women.

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Section: Discussionmentioning

confidence: 99%

Associations between the menstrual cycle, lifestyle factors and clinical assessment of the ocular surface: a prospective observational study

et al. 2020

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“…E. faecium WB2000 has been used in traditional Japanese medicine (Strong Wakamoto®) to treat gastrointestinal discomfort, and its effect on dry eye was reported recently [20]. Moreover, the effect of dentifrice containing E. faecium WB2000 on plaque control has been investigated [9].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect ofEnterococcus faeciumWB2000 on Volatile Sulfur Compound Production byPorphyromonas gingivalis

Suzuki

Higuchi

Nakajima

et al. 2016

International Journal of Dentistry

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Volatile sulfur compounds (VSCs) produced by oral anaerobes are the major compounds responsible for oral malodor. Enterococcus faecium WB2000 is recognized as an antiplaque probiotic bacterium. In this study, the effect of E. faecium WB2000 on VSC production by Porphyromonas gingivalis was evaluated, and the mechanism of inhibition of oral malodor was investigated. P. gingivalis ATCC 33277 was cultured in the presence of four lactic acid bacteria, including E. faecium WB2000. Subsequently, P. gingivalis ATCC 33277, W50, W83, and two clinical isolates were cultured in the presence or absence of E. faecium WB2000, and the emission of VSCs from spent culture medium was measured by gas chromatography. The number of P. gingivalis ATCC 33277 in mixed culture with E. faecium WB2000 decreased at 6 h, and the rate of decrease was higher than that in mixed cultures with the other lactic acid bacteria. The numbers of five P. gingivalis strains decreased at similar rates in mixed culture with E. faecium WB2000. The concentration of methyl mercaptan was lower in spent culture medium from P. gingivalis and E. faecium WB2000 cultures compared with that from P. gingivalis alone. Therefore, E. faecium WB2000 may reduce oral malodor by inhibiting the growth of P. gingivalis and neutralizing methyl mercaptan.

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“…In a mouse corneal alkali injury model, topical lactoferrin protected corneal epithelial cells from hydrogen peroxide oxidative damage [485], and when fed to one year old mice, reportedly reduced inflammation of both lacrimal glands and the conjunctiva, and reduced oxidative stress [486]. A lactoferrin supplement was recently reported to increase tearing in a randomized double blind placebo controlled dry eye study in humans [487], and to restore tearing and TBUT in a randomized controlled study of cataract surgery-induced dry eye [488]. Topical lacritin reduced corneal staining in the Aire −/− mouse model of dry eye [489] and promoted the health of cultured human corneal epithelial cells exposed to interferon gamma and tumor necrosis factor [481] or to benzalkonium chloride [490].…”

Section: Biochemical Properties Of Tearsmentioning

confidence: 99%

TFOS DEWS II Tear Film Report

et al. 2017

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The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears and how these change in DED. Clinically, DED is characterized by loss of tear volume, more rapid breakup of the tear film and increased evaporation of tears from the ocular surface. The tear film is composed of many substances including lipids, proteins, mucins and electrolytes. All of these contribute to the integrity of the tear film but exactly how they interact is still an area of active research. Tear film osmolarity increases in DED. Changes to other components such as proteins and mucins can be used as biomarkers for DED. The Subcommittee recommended areas for future research to advance our understanding of the tear film and how this changes with DED. The final report was written after review by all Subcommittee members and the entire TFOS DEWS II membership.

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Dietary Supplementation with a Combination of Lactoferrin, Fish Oil, and Enterococcus faecium WB2000 for Treating Dry Eye: A Rat Model and Human Clinical Study

Cited by 52 publications

References 21 publications

Associations between the menstrual cycle, lifestyle factors and clinical assessment of the ocular surface: a prospective observational study

Associations between the menstrual cycle, lifestyle factors and clinical assessment of the ocular surface: a prospective observational study

Inhibitory Effect ofEnterococcus faeciumWB2000 on Volatile Sulfur Compound Production byPorphyromonas gingivalis

TFOS DEWS II Tear Film Report

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