Dietary Supplementation with Fish Oil in Ulcerative Colitis

Stenson, William F.; Cort, David; Rodgers, Joseph T.; Burakoff, Robert; DeSchryver-Kecskemeti, K; Gramlich, Terri L.; Beeken, Warren L.

doi:10.7326/0003-4819-116-8-609

Cited by 356 publications

(155 citation statements)

References 24 publications

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“…Campos et al 21 observed less inflammatory alterations in the intestinal wall of the rats treated with lipid emulsions rich in omega-3 fatty acids and greater protection against the development of morphological lesions. Similarly, the preservation of the morphological structure with the use of omega-3 fatty acids was also demonstrated in experimental 22 and clinical studies 23 . It has been discovered that long-chain fatty acids appear to be more effective intestinal stimulators and significant trophic effects on small intestinal mucosa in rats 24 .…”

Section: Discussionmentioning

confidence: 99%

Flaxseed, olive and fish oil influence plasmatic lipids, lymphocyte migration and morphometry of the intestinal of Wistar rats

Rosa¹,

Sales²,

Moraes³

et al. 2010

Acta Cir. Bras.

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Purpose: Evaluate the effect of flaxseed, olive and fish oil on the lipid profile, preservation of villosities and lymphocyte migration in the intestinal mucosa of Wistar rats. Methods: Thirty Wistar male rats were divided into four groups, which received the AIN-93M diet, with changes only to their lipid source: flaxseed, olive, fish, and soy oil (control group). The serum was separated for the biochemical parameter analysis. A histological evaluation was performed in the ileal portion. Results: The group which was fed fish oil presented lower values when compared to the other treatments for Total Cholesterol, High-density Lipoprotein Cholesterol and Triacylglycerol (p<0.05). The animals treated with fish and olive oils presented better intestinal villosities preservation. Less deposition of lymphocytes was observed in the flaxseed group (p<0.001). Conclusions: This study demonstrated that flaxseed, olive and fish oils present different responses than soy oil for the intestinal mucosa preservation and lymphocyte proliferation in Wistar rats. Key words: Vegetable Fats. Linseed Oil. Soybean Oil. Fish Oils. Morphology. Intestines. Lymphocytes. Rats. RESUMO Objetivo:Avaliar o efeito dos óleos de linhaça, oliva e peixe no perfil lipídico, preservação das vilosidades e migração de linfócitos na mucosa intestinal de ratos Wistar. Métodos: Trinta ratos Wistar foram divididos em quarto grupos e receberam dieta AIN-93M, modificando para cada grupo apenas a fonte lipídica: óleo de linhaça, oliva, peixe e soja ( grupo controle). O soro foi separado para análise dos parâmetros bioquímicos. A análise histológica foi realizada na porção ileal. Resultados: O grupo que recebeu óleo de peixe apresentou menores valores de colesterol total, lipoproteína de alta densidade e triacilglicerol (p<0.05). Os animais tratados com óleo de peixe e oliva apresentaram melhor preservação das vilosidades intestinais. Menor deposição de linfócitos foi observado no grupo tratado com óleo de linhaça (p<0.001). Conclusão: Este estudo demonstrou que os óleos de linhaça, oliva e peixe apresentam diferentes respostas em relação ao óleo de soja na preservação da mucosa intestinal e proliferação de linfócitos em ratos Wistar. Descritores: Gorduras Vegetais. Óleo de Semente do Linho. Óleo de Soja. Óleos de Peixe. Morfologia. Intestino. Linfócitos. Ratos.

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Section: Discussionmentioning

confidence: 99%

Flaxseed, olive and fish oil influence plasmatic lipids, lymphocyte migration and morphometry of the intestinal of Wistar rats

Rosa¹,

Sales²,

Moraes³

et al. 2010

Acta Cir. Bras.

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“…Because n-3 PUFAs reduce tissue levels of the immunosuppressive agents arachidonic acid and prostaglandin E2, increased intake of n-3 PUFAs is hypothesised to enhance immune response. In fact, Pomposelli et al (1989) and Stenson et al (1992) have reported that dietary fats rich in n-3 or n-6 PUFAs, respectively, modulate inflammatory responses both in experimental animal models and in clinical trials. Diets enriched with n-3 PUFAs lead to reduced inflammatory reactions in experimental mice, with the significant development of different antibody types in response to antigenic stimulation in comparison to mice fed with an n-6 PUFA-enriched diet (Albers et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Effects of protected fish oil in the diet of periparturient dairy goats on phenotypic variation in blood and milk leukocytes

Bronzo

Puricelli

Agazzi

et al. 2010

Animal

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The goal of this study was to evaluate the effects of dietary protected fish oil (FO) on phenotypic variation in blood, milk leukocytes, and some productive and metabolic parameters in periparturient dairy goats. About 12 Alpine goats, selected from a larger group of second-parity animals, were fed from 15 days before kidding until the 15th day of lactation with the same basal diet that had been supplemented with either 47 g/head per day of FO or 47 g/head per day hydrogenated palm oil (PO). Dry matter intake, live body weight (LBW), body condition score (BCS), and productive performance were evaluated in 2 weeks after kidding. On days 15, 7, and 2 before kidding and days 2, 7, and 15 after kidding, plasma samples were collected for evaluation of alanine aminotransferase, aspartate aminotransferase, non-esterified fatty acids, glucose, beta-hydroxybutyrate, cholesterol, and urea levels. White blood cell and blood leukocyte subsets were counted in whole blood samples on the kidding day, as well as at 1, 4, and 15 days after kidding. In addition, milk somatic cell count, intramammary infection (IMI), and milk leukocyte subsets were evaluated on days 4 and 15 after kidding. No differences were observed in dry matter intake and BCS, while LBW was higher in FO-fed animals. Milk production and composition, plasma metabolites, and liver enzymes were similar in both experimental groups. Blood CD4 positive cells increased constantly ( P 5 0.05) in FO-fed group, while CD8 and CD14 cell counts significantly increased 4 days after kidding ( P , 0.01). Milk leukocyte subsets showed a significant ( P , 0.01) decrease in PO-fed group and a nonsignificant increase ( P 5 0.34) in FO-fed group, despite the presence of coagulase negative staphylococci IMI. The results of the productive performance evaluation agreed with those of many other studies, which did not find any significant differences between dairy goats fed diets enriched with FO or PO supplements. The administration of FO to dairy goats in transition appeared to affect the variation in blood leukocytes with a constant increase in CD4-and CD8-positive cells in comparison with a PO fat-supplemented diet.

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“…However, numerous researches have shown that antioxidants such as tocopherols and carotenoids can be transferred from the feed to the milk and thereby improve the oxidative stability of milk (Granelli et al, 1998). Omega 3 PUFA are considered as important modulators of immune reactions (Calder et al, 2002) as shown in experimental animal models (Pomposelli et al, 1989) and in clinical trials (Stenson et al, 1992). Mechanisms involved in the regulation of immune response may be related to PUFA influence on cellular communication and activation through the synthesis of prostaglandins, tumour necrosis factor-α, interferon-γ, and other factors such as nitric oxide (Calder et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Omega-3 supplementation, milk quality and cow immune-competence

et al. 2015

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This study aimed to assess the effect of a dietary supplementation rich in n-3 fatty acids from algae (Schizochytrium sp.) on cow immune-competence and milk quality. Twenty-one lactating Italian Friesian cows (at 220±20 days of lactation) were equally allocated to 3 treatments: group C received no supplementation, group D was offered 136 g of docosahexaenoic acid (DHA) per day and group E was supplemented with 136 g of DHA + 2000 U.I. of vitamin E per day. Individual milk production was recorded weekly and samples were collected for analysis of milk composition and fatty acid profile. At the end of the trial and 2 weeks later animals were subcutaneously injected with 5 mg of keyhole limpet haemocyanin (KLH), whereas at the end of the trial and 8 weeks later skinfold thickness was measured after intradermal injection with 500 mg phytohaemagglutinin. Dietary treatment showed no effect on milk production. Concentrations of DHA were higher (P<0.05) in milk fat from D and E groups, whereas polyunsaturated fatty acids tended to be higher (P<0.10). When DHA and DHA + vitamin E were supplemented to the animals, milk sensory properties were significantly modified as samples from groups D and E could be discriminated from the control using the triangle test (P<0.001). Both supplemented groups showed evidence of increased antibody response 4 to 8 weeks after the first KLH administration (P<0.05). In the two skin tests the treated groups showed a higher skin thickening in comparison with control animals (P<0.05).Although provided in a late stage of lactation, an n-3 fatty acid enriched diet favourably changed milk fatty acid profile and promoted animal healthiness by enhancing cellular and humoral immune response.

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Dietary Supplementation with Fish Oil in Ulcerative Colitis

Abstract: Four months of diet supplementation with fish oil in patients with inflammatory bowel disease resulted in reductions in rectal dialysate leukotriene B4 levels, improvements in histologic findings, and weight gain.

Cited by 356 publications

References 24 publications

Flaxseed, olive and fish oil influence plasmatic lipids, lymphocyte migration and morphometry of the intestinal of Wistar rats

Flaxseed, olive and fish oil influence plasmatic lipids, lymphocyte migration and morphometry of the intestinal of Wistar rats

Effects of protected fish oil in the diet of periparturient dairy goats on phenotypic variation in blood and milk leukocytes

Omega-3 supplementation, milk quality and cow immune-competence

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