Dietary Supplementation with Zinc Sulphate, Sodium Selenite and Fatty Acids in Early Dementia of Alzheimer's Type

A novel function for selenium in biological system: Selenite as a highly effective iron carrier for Chinese hamster ovary cell growth and monoclonal antibody production

“…The knowledge on its positive functions centered on its ability to protect cells from oxidative damage in vivo and in vitro (Davis et al, 1998;Patrick, 2004;van Rhiji et al, 1990;Yoon et al, 2002). It can be used either as an antioxidant or a pro-oxidant, and typically exists in selenoproteins in vivo and in various oxidative states in vitro, such as in the forms of selenite and selenate.…”

“…In either its organic form as selenoprotein, or its inorganic salt form as selenite (or selenate), selenium has been well known to exert various positive effects in biological system (Clark et al, 1996;Davis et al, 1998;Patrick, 2004;van Rhiji et al, 1990;Yoon et al, 2002). The established mechanisms include detoxifying free radicals by activating glutathione peroxidase, a key enzyme in the detoxification of oxygen radicals (Baker et al, 1998;Helmy et al, 2000;Maurer, 1992;Yoshiro et al, 2003), and serving as a cofactor for glutathione synthetase thus helping detoxify free radicals (Flohe et al, 1973;Frost and Lish, 1975;Oh et al, 1974).…”

Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer's type model in rats

“…There are data showing that Se is involved in most of the molecular pathways that are important in the progression of AD. Although there are controversial data associating the supplementation of Se with cognitive improvement and AD pathophysiology, some authors demonstrated favorable aspects of Se supplementation in AD patients [6][7][8]. Vural and colleagues [9] have reported that plasma Se levels are lower in AD patients when compared to healthy patients.…”

Vitamin-mineral supplements and intelligence

“…Smidt et al (1991) studied a sample of randomly selected healthy elderly women and found that those receiving thiamin supplementation reported increased well-being and less fatigue. The administration of various micronutrients has been associated with improved mental health and other psychological measures in the elderly (Tolonen et al 1985(Tolonen et al , 1988Van Rhijn et al 1990).…”