Dietary supplements in therapy to support weight reduction in obese patients [pdf]

Wawrzyniak, Natalia; Skrypnik, Katarzyna; Suliburska, Joanna

doi:10.17306/j.afs.2022.1010

Cited by 3 publications

(2 citation statements)

References 94 publications

(114 reference statements)

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“…Commercial supplements rarely describe the MW of chitosan. Still, it is shown that any MW chitosan used as a food supplement reduces the absorption of fat and cholesterol [42]. Chitosan diets generally reduce plasma lipid levels and increase the excretion of fat and cholesterol in the feces [31].…”

Section: Chitosanmentioning

confidence: 99%

Anti-Obesity Effects of Chitosan and Its Derivatives

Shagdarova,

Konovalova,

Varlamov

et al. 2023

Polymers

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The number of obese people in the world is rising, leading to an increase in the prevalence of type 2 diabetes and other metabolic disorders. The search for medications including natural compounds for the prevention of obesity is an urgent task. Chitosan polysaccharide obtained through the deacetylation of chitin, and its derivatives, including short-chain oligosaccharides (COS), have hypolipidemic, anti-inflammatory, anti-diabetic, and antioxidant properties. Chemical modifications of chitosan can produce derivatives with increased solubility under neutral conditions, making them potential therapeutic substances for use in the treatment of metabolic disorders. Multiple studies both in animals and clinical trials have demonstrated that chitosan improves the gut microbiota, restores intestinal barrier dysfunction, and regulates thermogenesis and lipid metabolism. However, the effect of chitosan is rather mild, especially if used for a short periods, and is mostly independent of chitosan’s physical characteristics. We hypothesized that the major mechanism of chitosan’s anti-obesity effect is its flocculant properties, enabling it to collect the chyme in the gastrointestinal tract and facilitating the removal of extra food. This review summarizes the results of the use of COS, chitosan, and its derivatives in obesity control in terms of pathways of action and structural activity.

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Section: Chitosanmentioning

confidence: 99%

Anti-Obesity Effects of Chitosan and Its Derivatives

Shagdarova,

Konovalova,

Varlamov

et al. 2023

Polymers

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“…In particular, it has been observed that obese individuals have lower levels of PYY compared to normal-weight individuals. This suggests that PYY may be involved in the pathophysiology of obesity ( 169 ). The exact mechanisms through which PYY regulates body weight are still not fully understood.…”

Section: Hormone Associated With Obesitymentioning

confidence: 99%

Exploring the underlying mechanisms of obesity and diabetes and the potential of Traditional Chinese Medicine: an overview of the literature

Chen,

Liu,

Teia

et al. 2023

Front. Endocrinol.

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Obesity and diabetes are closely related metabolic disorders that have become major public health concerns worldwide. Over the past few decades, numerous studies have explored the underlying mechanisms of these disorders and identified various risk factors, including genetics, lifestyle, and dietary habits. Traditional Chinese Medicine (TCM) has been increasingly recognized for its potential to manage obesity and diabetes. Weight loss is difficult to sustain, and several diabetic therapies, such as sulfonylureas, thiazolidinediones, and insulin, might make it harder to lose weight. While lifestyle changes should be the primary approach for people interested in lowering weight, drugs are also worth investigating. Since some of the newer glucose-lowering medications that cause weight loss, such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2i), are additionally utilized or are under consideration for use as anti-obesity drugs, the frontier between glucose-lowering medication and weight loss drugs appears to be shifting. This review provides an overview of the literature on the underlying mechanisms of obesity and diabetes and the prospect of TCM in their management. We discuss the various TCM interventions, including acupuncture, herbal medicine, and dietary therapy, and their effects on metabolic health. We also highlight the potential of TCM in regulating gut microbiota, reducing inflammation, and improving insulin sensitivity. The findings suggest that TCM may provide a promising approach to preventing and managing obesity and diabetes. However, further well-designed studies are needed to confirm the efficacy and safety of TCM interventions and to elucidate their underlying mechanisms of action.

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Phytotherapy in Obesity: Is It Necessary to Have Surgery?

AKÇAKAYA

2023

Bezmialem Science

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Dietary supplements in therapy to support weight reduction in obese patients [pdf]

Cited by 3 publications

References 94 publications

Anti-Obesity Effects of Chitosan and Its Derivatives

Anti-Obesity Effects of Chitosan and Its Derivatives

Exploring the underlying mechanisms of obesity and diabetes and the potential of Traditional Chinese Medicine: an overview of the literature

Phytotherapy in Obesity: Is It Necessary to Have Surgery?

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