Dietary sweet potato (Ipomoea batatas L.) leaf extract attenuates hyperglycaemia by enhancing the secretion of glucagon-like peptide-1 (GLP-1)

Nagamine, Rika; Shiori, Ueno; Tsubata, Masahito; Yamaguchi, Kazuya; Takagaki, Kinya; Hira, Tohru; Hara, Hiroshi; Tsuda, Takanori

doi:10.1039/c4fo00032c

Cited by 54 publications

(50 citation statements)

References 52 publications

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“…Administration of sulfonylurea was found to cause hypoglycemia by strongly inducing insulin secretion even when glucose was not given, whereas SP alone did not cause hypoglycemia. These results provide evidence that the mechanism of diabetes prevention and suppression in SP involves the stimulation of GLP‐1 secretion, and the promotion of insulin secretion when blood glucose is high, leading to the normalization of blood glucose level (Fig. ).…”

Section: Dietary Factors and Stimulation Of Glp‐1 Secretionmentioning

confidence: 63%

Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon‐like peptide‐1 secretion

Tsuda

2015

Molecular Nutrition Food Res

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There is a pressing need for countermeasures against diabetes, which has increased in incidence, becoming a global issue. Glucagon-like peptide-1 (GLP-1), a molecule secreted in enteroendocrine L cells in the lower small and large intestines, is thought to be one of the most important molecular targets for the prevention and treatment of diabetes. There has been increasing interest in the possible ability of dietary factors to treat diabetes via modulating GLP-1 secretion. There is thought to be a close relationship between incretin and diet, and the purported best approach for using dietary factors to increase GLP-1 activity is promotion of secretion of endogenous GLP-1. It have been reported that nutrients as well as various non-nutrient dietary factors can function as GLP-1 secretogogues. Here, we present our findings on the GLP-1 secretion-stimulating functions of two dietary factors, curcumin and extract of edible sweet potato leaves, which contain caffeoylquinic acid derivatives. However, it is necessary to reveal in greater detail the stimulation of GLP-1 secretion by dietary factors for preventing and treating diabetes. It is desirable to clarify the exact GLP-1 secretory pathway, the effect of metabolites derived from dietary factors in gut lumen, and the relationship between incretin and meal.

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Section: Dietary Factors and Stimulation Of Glp‐1 Secretionmentioning

confidence: 63%

Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon‐like peptide‐1 secretion

Tsuda

2015

Molecular Nutrition Food Res

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“…Six‐week‐old male Sprague‐Dawley (SD) rats (Japan SLC, Hamamatsu, Japan; n = 16) were maintained in an air‐conditioned environment (23 ± 3°C) under an automatic lighting schedule (08:00–20:00 light) with free access to water and a standard laboratory diet (MF, Oriental Yeast Co., Ltd., Tokyo, Japan). IPGTT was conducted using our previous published process (Kato, Nakanishi, Tani, & Tsuda, ; Kato, Nishikawa, et al., ; Nagamine et al., ). Briefly, rats were deprived of food for 13 hr at 7 weeks of age, before oral administration by direct stomach intubation of vehicle (control; 0.9% NaCl) or BCE 5 mg/kg body weight (1 mg D3R/kg body weight).…”

Section: Methodsmentioning

confidence: 99%

“…After 30 min, rats received IP administration of glucose solution (2 g/kg). Blood samples were collected at 0 (before glucose loading), 15, 30, 60, and 120 min after glucose injections, and serum glucose and insulin concentrations were measured with Glucose CII‐Test (Wako) and Ultra Sensitive Rat Insulin ELISA kit (Morinaga Institute of Biological Science, Yokohama, Japan), respectively (Kato, Nakanishi et al., ; Kato, Nishikawa, et al., ; Nagamine et al., ).…”

Section: Methodsmentioning

confidence: 99%

“…After administration of BCE followed by IP glucose solution as described in Section , blood samples were collected from the portal vein under anesthesia (isoflurane) 15 and 30 min after glucose loading, or 45 and 60 min after vehicle or BCE administration. Blood was drawn into a syringe containing EDTA disodium salt (final concentration, 1 mg/ml; Dojindo, Kumamoto, Japan), aprotinin (final concentration, 500 KIU/ml; Wako), and dipeptidyl peptidase‐IV inhibitor (final concentration, 100 μmol/L; Diprotin A; Peptide Institute, Inc., Osaka, Japan) (Kato, Nakanishi et al., ; Kato, Nishikawa, et al., ; Nagamine et al., ). Samples were centrifuged at 1,600 g for 15 min at 4°C, and plasma total GLP‐1 concentrations were measured using an ELISA (GLP‐1 Total ELISA kit, Millipore, St. Charles, MS) according to the manufacturer's instructions.…”

Section: Methodsmentioning

confidence: 99%

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Delphinidin 3‐rutinoside‐rich blackcurrant extract ameliorates glucose tolerance by increasing the release of glucagon‐like peptide‐1 secretion

Tani

Nishikawa

Kato

et al. 2017

Food Science & Nutrition

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Glucagon‐like peptide‐1 (GLP‐1) is an incretin that is secreted from enteroendocrine L‐cells. Dietary factor‐stimulation of endogenous GLP‐1 is a promising strategy for increasing the action of GLP‐1. Recent studies have shown that berries rich in anthocyanins improve insulin sensitivity and reduce the risk of type 2 diabetes. Our previous study found that the anthocyanin delphinidin 3‐rutinoside (D3R) significantly increases GLP‐1 secretion in GLUTag cells (enteroendocrine L cell line). Blackcurrants are berries that contain high levels of anthocyanins, particularly D3R. Pre‐administered blackcurrant extract (BCE) 5 mg/kg body weight (1 mg D3R/kg) significantly ameliorated glucose tolerance after intraperitoneal glucose injection in rats by stimulating the secretion of GLP‐1 and subsequently inducing insulin secretion. D3R did not break down significantly in the gastrointestinal tract for at least 45−60 min after BCE was administered, suggesting that BCE‐induced GLP‐1 secretion is mainly mediated by D3R and not its degradation products. These findings demonstrate the novel biological function of D3R‐rich BCE as a GLP‐1 secretagogue. An increase in endogenous GLP‐1 secretion induced by BCE may help to reduce the dosages of diabetic medicines and prevent diabetes.

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“…It is suggested that anthocyanins, as natural pigments, may provide beneficial health effects. Studies proved anthocyanin provide physiological functions such as antihyperglycemic [4], antiinflamatory and anticarcinogenic [5] and antioxidant [6].…”

Section: Introductionmentioning

confidence: 99%

Physico Chemical, Antioxidant and Pasting Properties of Pre-heated Purple Sweet Potato Flour

Nurdjanah¹,

Yuliana²,

Astuti³

et al. 2017

JFNS

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Purple sweet potatoes contain anthocyanins which could function as a natural food colorant, and an antioxidant.One of the problems in handling the fresh roots is their susceptibility during storage, and to extend their uses, fresh purple sweet potato could be processed into flour. However, during flouring process, the properties of the purple sweet potato may undergo some changes such as partial gelatinization of the starch and discolorization. Therefore, the purpose of this study was to investigate the effect of pre-heating treatment during flouring process on degree of gelatinization, the anthocyanin content, the antioxidant activity and the total phenolic content of heat treated purple sweet potato flour. Other objectives were to observed the changes in the starch properties such as rheological properties, granular appearance of the heat treated-purple sweet potato flour. Pre-heating treatment of purple sweet potato flour was prepared by heating grated purple sweet potato in a single rotary drum cooker at 90°C for 15, 30, 45, 60 and 75 min, followed by drying in a cabinet dryer at 60°C for 8 h. The results showed the longer pre-heating time at 90°C had caused increase in the degree of gelatinization, increase in total phenolic and anthocyanin retention. In addition, differences in gelatinization temperature, maximum viscosity, paste stability and retrogradation, and differences in scanning electron microscope (SEM) of granular appearance were also observed. The overall results indicated that pre-heating treatment can be used for modifying the physical, chemical and rheological properties to suit various applications and preserving functional properties of purple sweet potato flour.

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Dietary sweet potato (Ipomoea batatas L.) leaf extract attenuates hyperglycaemia by enhancing the secretion of glucagon-like peptide-1 (GLP-1)

Cited by 54 publications

References 52 publications

Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon‐like peptide‐1 secretion

Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon‐like peptide‐1 secretion

Delphinidin 3‐rutinoside‐rich blackcurrant extract ameliorates glucose tolerance by increasing the release of glucagon‐like peptide‐1 secretion

Physico Chemical, Antioxidant and Pasting Properties of Pre-heated Purple Sweet Potato Flour

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