Dietary tea tree (<i>Melaleuca alternifolia</i>) oil supplementation enhances the expressions of amino acid transporters in goat ileal mucosa and improves intestinal immunity

Lv, Xiaokang; Chen, Liang; Zhou, Chunfang; Guo, Yibing; Zhang, Guijie; Kang, Jinhe; Tan, Zhiliang; Tang, Shaoxun; Liu, Zixin

doi:10.1002/fsn3.2972

Cited by 3 publications

(3 citation statements)

References 65 publications

(71 reference statements)

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“…TTO has a significant effect on improving immunity. The levels of TNF-α and IL-12 in the guts of goats fed with TTO were significantly downregulated, and the expression level of IL-2 was significantly increased, leading to immunity ( Lv et al, 2022 ). However, TTO was found to significantly reduce the content of NF-κB in the rumen of sheep, thereby inhibiting the expression of inflammatory cytokines ( Hu et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Tea tree oil inhibits hydrogen sulfide-induced oxidative damage in chicken lungs through CYP450s/ROS pathway

Liang,

Jiang,

et al. 2024

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Tea tree oil inhibits hydrogen sulfide-induced oxidative damage in chicken lungs through CYP450s/ROS pathway

Liang,

Jiang,

et al. 2024

Poultry Science

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“…2 A total of 2029 cuproptosis-related genes (Supplementary Table S1) were retrieved from the public GeneCards database. 3…”

Section: Samples and Data Collectionmentioning

confidence: 99%

“…Ganxi goats are an excellent local breed mainly raised in the western part of Jiangxi province, with the characteristics of small body size, strong adaptability, and a high reproductive rate. The existing studies mainly focus on transport stress ( 1 ), antioxidant capacity ( 2 ), intestinal immunity ( 3 ) and genome ( 4 ), but there is no study on wound healing in Ganxi goats. Therefore, in this study, transcriptomics was used for the first time to analyze the skin on 0d and 5d of wounds in Ganxi goats, and the physiological function of skin wound healing was discussed from the perspective of mRNA.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic profiling identifies differentially expressed genes and related pathways associated with wound healing and cuproptosis-related genes in Ganxi goats

et al. 2023

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IntroductionWound healing is very important for the maintenance of immune barrier integrity, which has attracted wide attention in past 10 years. However, no studies on the regulation of cuproptosis in wound healing have been reported.MethodsIn this study, the skin injury model was constructed in Gnxi goats, and the function, regulatory network and hub genes of the skin before and after the injury were comprehensively analyzed by transcriptomics.ResultsThe results showed that there were 1,438 differentially expressed genes (DEGs), genes up-regulated by 545 and genes down-regulated by 893, which were detected by comparing day 0 and day 5 posttraumatic skin. Based on GO-KEGG analysis, DEGs that were up-regulated tended to be enriched in lysosome, phagosome, and leukocyte transendothelial migration pathways, while down-regulated DEGs were significantly enriched in adrenergic signaling in cardiomyocytes and calcium signaling pathway. There were 166 overlapped genes (DE-CUGs) between DEGs and cuproptosis-related genes, with 72 up-regulated DE-CUGs and 94 down-regulated DE-CUGs. GOKEGG analysis showed that up-regulated DE-CUGs were significantly enriched in ferroptosis, leukocyte transendothelial migration and lysosome pathways, while down-regulated DE-CUGs were significantly enriched in Apelin signaling pathway and tyrosine metabolism pathways. By constructing and analyzing of protein–protein interaction (PPI) networks of DEGs and DE-CUGs, 10 hub DEGs (ENSCHIG00000020079, PLK1, AURKA, ASPM, CENPE, KIF20A, CCNB2, KIF2C, PRC1 and KIF4A) and 10 hub DE-CUGs (MMP2, TIMP1, MMP9, MMP14, TIMP3, MMP1, EDN1, GCAT, SARDH, and DCT) were obtained, respectively.DiscussionThis study revealed the hub genes and important wound healing pathways in Ganxi goats, and identified the correlation between wound healing and cuproptosis for the first time, and found that MMP2, TIMP1, MMP9, and EDN1 were the core genes associated. This study enriched the transcriptome data of wound healing in Ganxi goats and expanded the research direction of cuproptosis.

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Bacterial resistance in diarrhea and tea tree oil as a potential alternative treament: a review

González González,

Guerrero-Encinas,

Morales-Figueroa

et al. 2024

BIOTECNIA

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Bacterial diarrhea is a global health concern, particularly in developing countries like Mexico, where high morbidity and mortality rates persist, especially in children under five years old. While antibiotics like ciprofloxacin, ceftriaxone, and azithromycin are effective, increasing bacterial resistance has led to the search for alternatives. Tea tree essential oil (TTEO) has been proposed as a potential treatment, but research, especially in vivo, remains limited due to oil composition variability and a lack of standardized protocols. This review compiles current data (2000-2024) on the epidemiology, diagnosis, treatment, and antibiotic resistance of critical diarrhea-causing bacteria (E. coli, Shigella spp., Campylobacter spp., and Salmonella spp.) and evaluates TTEO’s antibacterial potential. In vitro studies show its bactericidal and bacteriostatic effects, while in vivo studies assess its therapeutic impact on animal models. In conclusion, TTEO holds promise as an alternative or adjuvant to antibiotics for treating bacterial diarrhea. However, further in vivo studies are required to confirm its efficacy and optimize its clinical application.

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Dietary tea tree (Melaleuca alternifolia) oil supplementation enhances the expressions of amino acid transporters in goat ileal mucosa and improves intestinal immunity

Cited by 3 publications

References 65 publications

Tea tree oil inhibits hydrogen sulfide-induced oxidative damage in chicken lungs through CYP450s/ROS pathway

Tea tree oil inhibits hydrogen sulfide-induced oxidative damage in chicken lungs through CYP450s/ROS pathway

Transcriptomic profiling identifies differentially expressed genes and related pathways associated with wound healing and cuproptosis-related genes in Ganxi goats

Bacterial resistance in diarrhea and tea tree oil as a potential alternative treament: a review

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