Dietary treatment with rice containing resistant starch improves markers of endothelial function with reduction of postprandial blood glucose and oxidative stress in patients with prediabetes or newly diagnosed type 2 diabetes

Kwak, Jung Hyun; Paik, Jean Kyung; Kim, Hye In; Kim, Oh Yoen; Shin, Dong Yeob; Kim, Hye Jin; Lee, Jin Hee; Lee, Jong Ho

doi:10.1016/j.atherosclerosis.2012.08.003

Cited by 94 publications

(84 citation statements)

References 24 publications

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“…Changes in urinary 8-epi-PGF 2 ␣ concentrations were positively correlated with changes in fasting glucose, which were also strongly correlated with changes in plasma MDA, a marker of oxygen-derived free radicals. Similarly, recent studies of dietary treatment in patients with prediabetes or newly diagnosed T2D have shown that changes in MDA positively correlate with changes in fasting glucose and glucose response area during meal tolerance test ( 28 ).…”

Section: Downloaded Frommentioning

confidence: 99%

Replacing with whole grains and legumes reduces Lp-PLA2 activities in plasma and PBMCs in patients with prediabetes or T2D

Kim

Jeung

Jeong

et al. 2014

Journal of Lipid Research

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This article is available online at http://www.jlr.org Supplementary key words lipoprotein-associated phospholipase A 2 • peripheral blood mononuclear cell • type 2 diabetes Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) has been consistently higher among type 2 diabetics than nondiabetics ( 1-3 ), and independently predicts incident T2D ( 4 ). However, little is known about the dietary treatment that may alter circulating Lp-PLA 2 activity levels. In a recent large cross-sectional study of men and women, the observation of an inverse association between protein intakes and circulating Lp-PLA 2 activity suggests that nutritional factors may have the potential to infl uence Lp-PLA 2 activity ( 5 ). Additionally, a small interventional study with low-calorie diet showed that an average 10 kg weight loss achieved over 4 months in healthy obese women was associated with a 10% decrease in Lp-PLA 2 activity ( 6 ). These recent studies ( 5, 6 ) suggest that diet may represent a potentially modifi able pathway through which Lp-PLA 2 activity can be altered. However, no study has examined the effects of dietary treatment on circulating Lp-PLA 2 activity in patients with T2D.According to the 2010 Korean National Health and Nutrition Survey (KNHANES V-1), carbohydrate-derived calories account for 65% of total caloric intake, and cooked refi ned rice is the major source of carbohydrates in middle-aged adults. Because of this high carbohydrate intake, Abstract To determine dietary effects on circulating lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) activity and enzyme activity in peripheral blood mononuclear cells (PBMCs), 99 patients with impaired fasting glucose, impaired glucose tolerance, or newly-diagnosed T2D were randomly assigned to either a control group (usual diet with refi ned rice) or the whole grain and legume group. Substitution of whole grains and legumes for refined rice was associated with the replacement of 7% of energy from carbohydrates with energy from protein (about 4%) and fat. After 12 weeks, the whole grain and legume group showed a signifi cant decrease in fasting glucose, insulin, homeostasis model assessment-insulin resistance, hemoglobin A 1c , malondialdehyde, plasma Lp-PLA 2 activity, and oxidized LDL (ox-LDL), and an increase in LDL particle size. The changes ( ⌬ s) in these variables in the whole grain and legume group were signifi cantly different from those in controls after adjustment for the baseline levels. When all subjects were considered, ⌬ plasma Lp-PLA 2 positively correlated with ⌬ glucose, ⌬ PBMC Lp-PLA 2 , ⌬ ox-LDL, and ⌬ urinary 8-epiprostaglandin F 2 ␣ after being adjusted for confounding factors. The ⌬ PBMC Lp-PLA 2 correlated positively with ⌬ glucose and ⌬ ox-LDL, and negatively with ⌬ LDL particle size and baseline PBMC Lp-PLA 2 . The substitution of whole grains and legumes for refi ned rice resulted in a reduction in Lp-PLA 2 activities in plasma and PBMCs partly through improved glycemic control, increased consumption of protein relative to carbohydrate, an...

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Section: Downloaded Frommentioning

confidence: 99%

Replacing with whole grains and legumes reduces Lp-PLA2 activities in plasma and PBMCs in patients with prediabetes or T2D

Kim

Jeung

Jeong

et al. 2014

Journal of Lipid Research

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“…Over time, poor diet quality leads to increased oxidative stress, which has been associated with increased risk of atherosclerosis and related disorders [57]. Their findings indicated that consumption of rice containing HAMRS2 for 4 weeks resulted in improved endothelial function, reduced postprandial glucose, and reduce oxidative stress in patients with impaired fasting glucose or impaired glucose tolerance [11]. Endothelial dysfunction is an early indicator of vascular damage and cardiovascular disease [59].…”

Section: Rs and Oxidative Stressmentioning

confidence: 99%

“…Kwak et al investigated the effects of RS on postprandial oxidative stress in prediabetic individuals [11]. Consumption of a high-fat and/or carbohydrate meal results in postprandial oxidative stress (oxidative stress caused by the metabolism of a consumed meal), particularly a meal high in saturated fat [56][57][58].…”

Section: Rs and Oxidative Stressmentioning

confidence: 99%

“…Resistant starch (RS) is a non-viscous fermentable fiber that is easily fortified into food products [10] and has generally been shown to have beneficial metabolic effects on glucose tolerance and insulin sensitivity, endothelial function, and colon health [11,12]. Refer to [10,13] for comprehensive reviews of the effect of RS on insulin sensitivity.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Resistant Starch Intake in Humans

Sweat¹

2016

F Nutr Reprt

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Due to the rise in obesity and obesity-related conditions, there is growing commercial and public interest in foods and food components that promote health and lower risk of chronic metabolic diseases. Resistant starch (RS) is a non-viscous fermentable fiber that has beneficial metabolic effects on glucose tolerance, insulin sensitivity, and colon health in humans. While the mechanism behind the effects of RS are unclear, the benefits are thought to result from fermentation of RS in the large bowel by colonic bacteria resulting in a more favorable gut microbial composition and increased concentration of short-chain fatty acids (SCFAs). Evidence indicates that RS may result in increased colonic bacterial species Ruminococcus bromii (R. bromii), and in phylum level changes in Bacteriodetes and Fermicutes. The increase in SCFAs has been shown to potentially play a role in lowering gut pH to improve health, contribute to appetite control and reduced adipose tissue lipolysis; and reduce postprandial serum oxidative stress. Additionally, evidence indicates RS aids in treatment of diarrheal disease by interacting with both the human to increase SCFA concentration, water retention, and fecal weight and to interact with the disease-causing agent such that the insult to the human lumen cells is reduced. Therefore, RS may be a potent dietary therapy for individuals at risk for conditions including metabolic syndrome, type-2 diabetes, colorectal cancer, and diarrheal diseases. The effects of type, dose, and duration of RS intake and subsequent impact on health are important areas of further research.

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“…Dietary treatment on patients who have impaired fasting glucose, impaired glucose tolerance or newly diagnosed type 2 diabetes with resistant starch reduced fasting insulin and insulin resistance, postprandial glucose and insulin levels [19]. A study in a single-blinded, randomized, parallel nutritional intervention for 20 insulin resistant subjects has demonstrated therapeutic effect of resistant starch treatment by showing improved insulin sensitivity, waist circumference and fat storage in tibialis muscle [20].…”

Section: Health Benefits Of Resistant Starchmentioning

confidence: 99%

Resistant Starch Regulates Gut Microbiota: Structure, Biochemistry and Cell Signalling

Yang

Darko

Huang

et al. 2017

Cell Physiol Biochem

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Starch is one of the most popular nutritional sources for both human and animals. Due to the variation of its nutritional traits and biochemical specificities, starch has been classified into rapidly digestible, slowly digestible and resistant starch. Resistant starch has its own unique chemical structure, and various forms of resistant starch are commercially available. It has been found being a multiple-functional regulator for treating metabolic dysfunction. Different functions of resistant starch such as modulation of the gut microbiota, gut peptides, circulating growth factors, circulating inflammatory mediators have been characterized by animal studies and clinical trials. In this mini-review, recent remarkable progress in resistant starch on gut microbiota, particularly the effect of structure, biochemistry and cell signaling on nutrition has been summarized, with highlights on its regulatory effect on gut microbiota.

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Dietary treatment with rice containing resistant starch improves markers of endothelial function with reduction of postprandial blood glucose and oxidative stress in patients with prediabetes or newly diagnosed type 2 diabetes

Cited by 94 publications

References 24 publications

Replacing with whole grains and legumes reduces Lp-PLA2 activities in plasma and PBMCs in patients with prediabetes or T2D

Replacing with whole grains and legumes reduces Lp-PLA2 activities in plasma and PBMCs in patients with prediabetes or T2D

Effects of Resistant Starch Intake in Humans

Resistant Starch Regulates Gut Microbiota: Structure, Biochemistry and Cell Signalling

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