Dietary triacylglycerol hydroperoxide is not absorbed, yet it induces the formation of other triacylglycerol hydroperoxides in the gastrointestinal tract

Lipid Structure Influences the Digestion and Oxidation Behavior of Docosahexaenoic and Eicosapentaenoic Acids in the Simulated Digestion System

“…The same authors reported the reduction of hydroperoxidized fatty acids to hydroxy species not only in vivo but also ex vivo with rat small intestine mucosa homogenate. 47 This reduction has also been observed in Caco-2 cell lines by other authors. 48 While there is general agreement on the pro-oxidant conditions of the gastrointestinal tract, the effect of lipolysis on lipid oxidation is less understood.…”

“…Therefore, oxidation damage propagated in the gastrointestinal tract. The same authors reported the reduction of hydroperoxidized fatty acids to hydroxy species not only in vivo but also ex vivo with rat small intestine mucosa homogenate . This reduction has also been observed in Caco-2 cell lines by other authors …”

Comparison of the Catabolic Rates of Linoleic and Oleic Acid Hydroperoxides Using ¹³CO₂ Expired from Mice

“…Kanazawa et al reported that small amounts of C18:2-OOH are transported to the intestine when excess amounts of C18:2-OOH (800 μmol) are intragastrically administered 13) . In contrast, another study indicated that lipid hydroperoxides are not incorporated into tissue lipids when small amounts of C18:2-OOH are administered via the stomach 13,16) . Takahashi et al performed a lymph duct cannulation study in rats using deuterium-labeled trioleoyl glycerol hydroperoxide (D 2 -TG-OOH) .…”

“…After administration, unlabeled TG-OOH was detected instead of D 2 -TG-OOH in the lymph of mice. Therefore, the authors suggested that dietary TG-OOH was not absorbed from the intestine as a lipid hydroperoxide, as D 2 -TG-OOH was not detected in the lymph of rats 16) . In addition, they reported that the intake of dietary TG-OOH promoted oxidative stress and induced in situ formation of TG-OOH.…”

Mechanisms underlying the Effects of Heat Stress on Intestinal Integrity, Inflammation, and Microbiota in Chickens

“…Based on this evidence, a diet rich in oxidants is likely to induce an intestinal inflammatory response and oxidative damage, possibly owing to NF-κB activation and downregulation of nuclear factor-erythroid 2-related factor ( Ringseis et al ., 2016 ; Dong et al ., 2020 ), an emerging regulator of cellular resistance to oxidants. A recent investigation demonstrated that lipid hydroperoxide was not absorbed but rather gave rise to other lipid hydroperoxides in the gastrointestinal tract ( Takahashi et al ., 2022 ). Moreover, lipid oxidation levels in chickens fed oxidized oil correlated negatively with α-tocopherol ( Sheehy et al ., 1994 ), lutein, β-carotene, and retinol levels ( Engberg et al ., 1996 ).…”