Dietary vitamin A regulates wingless-related MMTV integration site signaling to alter the hair cycle

Suo, Liye; Sundberg, John P.; Everts, Helen B.

doi:10.1177/1535370214557220

Cited by 20 publications

(15 citation statements)

References 56 publications

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“…The inhibited Wnt/ β -catenin activity may be attributed to an upregulation of canonical Wnt signaling inhibitors and activation of noncanonical Wnt pathway, leading to an UDP-mediated β -catenin degradation [ 5 ]. These findings are in line with the evidence of a decreased AA lesional skin with Wnt10b activated-canonical Wnt signaling [ 137 ] and an increased stemness of hair follicle stem cells induced by a vitamin A-enhanced Wnt signaling to be activated [ 57 ].…”

Section: Wnt Signaling As Potential Biomarkers and Therapeutic Tarsupporting

confidence: 87%

“…Alopecia areata (AA) is an autoimmune disease manifested hair loss, which is caused by a cell-mediated immune attack of the cycling hair follicle [ 57 ]. Impaired Wnt/ β -catenin has been shown to stagnate anagen initiation and disable stem cells to differentiation to hair keratinocytes rather than epidermal cells instead [ 135 , 136 ].…”

Section: Wnt Signaling As Potential Biomarkers and Therapeutic Tarmentioning

confidence: 99%

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Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

Shi

Chi

Xue

et al. 2016

Journal of Immunology Research

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The Wnt signaling pathway plays a key role in many biological aspects, such as cellular proliferation, tissue regeneration, embryonic development, and other systemic effects. Under a physiological condition, it is tightly controlled at different layers and arrays, and a dysregulated activation of this signaling has been implicated into the pathogenesis of various human disorders, including autoimmune diseases. Despite the fact that therapeutic interventions are available for ameliorating disease manifestations, there is no curative therapy currently available for autoimmune disorders. Increasing lines of evidence have suggested a crucial role of Wnt signaling during the pathogenesis of many autoimmune diseases; in addition, some of microRNAs (miRNAs), a class of small, noncoding RNA molecules capable of transcriptionally regulating gene expression, have also recently been demonstrated to possess both physiological and pathological roles in autoimmune diseases by regulating the Wnt signaling pathway. This review summarizes currently our understanding of the pathogenic roles of Wnt signaling in several major autoimmune disorders and miRNAs, those targeting Wnt signaling in autoimmune diseases, with a focus on the implication of the Wnt signaling as potential biomarkers and therapeutic targets in immune diseases, as well as miRNA-mediated regulation of Wnt signaling activation in the development of autoimmune diseases.

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Section: Wnt Signaling As Potential Biomarkers and Therapeutic Tarsupporting

confidence: 87%

Section: Wnt Signaling As Potential Biomarkers and Therapeutic Tarmentioning

confidence: 99%

Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

Shi

Chi

Xue

et al. 2016

Journal of Immunology Research

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“…Mice fed high levels of vitamin A developed earlier onset of disease, but those which were not fed supplements had the most severe form of disease. Suo et al [94] demonstrated similar findings in C3H/HeJ mice, showing a dose-dependent role for vitamin A in the initiation of the anagen hair cycle, which might increase follicle susceptibility to autoimmune destruction. Ultimately, these studies suggest the notion that there exists a certain optimized level of vitamin A, and too little or too much of this compound might favor the development, maintenance, or progression of AA.…”

Section: Micronutrientsmentioning

confidence: 73%

The Role of Micronutrients in Alopecia Areata: A Review

et al. 2017

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Alopecia areata (AA) is a common, non-scaring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given their role in normal hair follicle development and in immune cell function, a growing number of investigations have sought to determine whether serum levels of these nutrients might differ in AA patients, and whether supplementation of these nutrients might represent a therapeutic option for AA. While current treatment often relies on invasive steroid injections or immunomodulating agents with potentially harmful side-effects, therapy by micronutrient supplementation, whether as a primary modality or as adjunctive treatment, could offer a promising low-risk alternative. However, our review highlights a need for further research in this area, given that the current body of literature largely consists of small case-control studies and case-reports which preclude any definite conclusions for a role of micronutrients in AA. In this comprehensive review of the current literature we found that serum vitamin D, zinc, and folate levels tend to be lower in patients with AA as compared to controls. Evidence is conflicting or insufficient to suggest differences in levels of iron, vitamin B12, copper, magnesium, or selenium. A small number of studies suggest that vitamin A levels may modify the disease. Though understanding of the role for micronutrients in AA is growing, definitive clinical recommendations such as routine serum level testing or therapeutic supplementation, call for additional studies in larger populations and with a prospective design.

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“…confirmed a role for vitamin A in the initiation of the anagen hair cycle in C3H/HeJ mice, which likely increases follicle susceptibility to autoimmune destruction and it was dose-dependent. [ 86 ]…”

Section: Investigational Treatments and Future Directionsmentioning

confidence: 99%

Alopecia areata: Review of epidemiology, clinical features, pathogenesis, and new treatment options

et al. 2018

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Alopecia areata (AA) is a complex autoimmune condition that causes nonscarring hair loss. It typically presents with sharply demarcated round patches of hair loss and may present at any age. In this article, we review the epidemiology, clinical features, pathogenesis, and new treatment options of AA, with a focus on the immunologic mechanism underlying the treatment. While traditional treatment options such as corticosteroids are moderately effective, a better understanding of the disease pathogenesis may lead to the development of new treatments that are more directed and effective against AA. Sources were gathered from PubMed, Embase, and the Cochrane database using the keywords: alopecia, alopecia areata, hair loss, trichoscopy, treatments, pathogenesis, and epidemiology.

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Dietary vitamin A regulates wingless-related MMTV integration site signaling to alter the hair cycle

Cited by 20 publications

References 56 publications

Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases

The Role of Micronutrients in Alopecia Areata: A Review

Alopecia areata: Review of epidemiology, clinical features, pathogenesis, and new treatment options

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