Dietary vitamin A supplementation prevents early obesogenic diet-induced microbiota, neuronal and cognitive alterations

Biyong, Essi F.; Alfos, Serge; Dumetz, Fabien; Helbling, Jean‐Christophe; Aubert, Agnès; Brossaud, Julie; Foury, Aline; Moisan, Marie‐Pierre; Layé, Sophie; Richard, Emmanuel; Patterson, Elaine; Murphy, Kiera; Rea, Kieran; Stanton, Catherine; Schellekens, Harriët; Cryan, John F.; Capuron, Lucile; Pallet, Véronique

doi:10.1038/s41366-020-00723-z

Cited by 24 publications

(23 citation statements)

References 56 publications

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“…83 In a murine study of C57BL/6J weaning male, the effect of vitamin A supplementation in condition of standard (CD) or high-fat highsugar diet (HFSD) was studied. 91 Vitamin A was administered in the form of retinol, directly incorporated to the diet. These studies reinforce the links between vitamins and GM as oral vitamin supplementation is reported to induce modifications of the GM composition.…”

Section: Effect Of Vitamin Supplementation On Gmmentioning

confidence: 99%

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Gut microbiota and vitamin status in persons with obesity: A key interplay

et al. 2021

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There are numerous factors involved in obesity progression and maintenance including systemic low-grade inflammation, adipose tissue dysfunction, or gut microbiota dysbiosis. Recently, a growing interest has arisen for vitamins' role in obesity and related disorders, both at the host and gut bacterial level. Indeed, vitamins are provided mostly by food, but some, from the B and K groups in particular, can be synthesized by the gut bacterial ecosystem and absorbed in the colon. Knowing that vitamin deficiency can alter many important cellular functions and lead to serious health issues, it is important to carefully monitor the vitamin status of patients with obesity and potentially already existing comorbidities as well as to examine the dysbiotic gut microbiota and thus potentially altered bacterial metabolism of vitamins. In this review, we examined both murine and human studies, to assess the prevalence of sub-optimal levels of several vitamins in obesity and metabolic alterations. This review also examines the relationship between vitamins and the gut microbiota in terms of vitamin production and the modulation of the gut bacterial ecosystem in conditions of vitamin shortage or supplementation. Furthermore, some strategies to improve vitamin status of patients with severe obesity are proposed within this review.

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Section: Effect Of Vitamin Supplementation On Gmmentioning

confidence: 99%

“…In a murine study of C57BL/6J weaning male, the effect of vitamin A supplementation in condition of standard (CD) or high‐fat high‐sugar diet (HFSD) was studied 91 . Vitamin A was administered in the form of retinol, directly incorporated to the diet.…”

Section: Effect Of Vitamin Supplementation On Gmmentioning

confidence: 99%

Gut microbiota and vitamin status in persons with obesity: A key interplay

et al. 2021

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“…These dietary lipids play an indispensable role in CNS development, anti-inflammatory processes [ 13 ], they possess neuroprotective properties and affect neuronal plasticity [ 14 ]. Additionally, vitamin A plays a key role in regulating synaptic plasticity, learning and memory through its active metabolite, retinoic acid [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Diet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner

Costa

Rani

Bastiaanssen

et al. 2022

IJMS

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Exposure to repeated social stress may cause maladaptive emotional reactions that can be reduced by healthy nutritional supplementation. Histaminergic neurotransmission has a central role in orchestrating specific behavioural responses depending on the homeostatic state of a subject, but it remains to be established if it participates in the protective effects against the insults of chronic stress afforded by a healthy diet. By using C57BL/6J male mice that do not synthesize histamine (Hdc−/−) and their wild type (Hdc+/+) congeners we evaluated if the histaminergic system participates in the protective action of a diet enriched with polyunsaturated fatty acids and vitamin A on the deleterious effect of chronic stress. Behavioural tests across domains relevant to cognition and anxiety were performed. Hippocampal synaptic plasticity, cytokine expression, hippocampal fatty acids, oxylipins and microbiota composition were also assessed. Chronic stress induced social avoidance, poor recognition memory, affected hippocampal long-term potentiation, changed the microbiota profile, brain cytokines, fatty acid and oxylipins composition of both Hdc−/−and Hdc+/+ mice. Dietary enrichment counteracted stress-induced deficits only in Hdc+/+ mice as histamine deficiency prevented almost all of the diet-related beneficial effects. Interpretation: Our results reveal a previously unexplored and novel role for brain histamine as a mediator of many favorable effects of the enriched diet. These data present long-reaching perspectives in the field of nutritional neuropsychopharmacology.

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“…Thus, a reduced intake of fruits and vegetables as a potential source of provitamin A5/X and thus a correlation of nutritional pattern frequent in Western society with an increased incidence of depression and other neuropsychiatric disorders may also depend on vitamin A5/X availability for enabling sufficient RXR-mediated signaling ( Bishwajit et al, 2017 ; Joseph et al, 2009 ; Spencer et al, 2017 ). Furthermore, we cannot exclude that high fat, high sugar diets strongly associated with Western nutritional patterns may also impact vitamin A5/X availability similarly to that reported for compromised vitamin A1 signaling in the brain ( Biyong et al, 2020 ; Buaud et al, 2010 ). As a solution, a more healthy dietary pattern with fruits/vegetables, rich in carotenoids and especially provitamin A5/X ( Böhm et al, 2020 ) or alternatively direct food enrichment or a dietary supplementation might be a solution of this identified nutrition-dependent health problem.…”

Section: Discussionmentioning

confidence: 92%

Vitamin A5/X controls stress-adaptation and prevents depressive-like behaviors in a mouse model of chronic stress

Krzyżosiak

Podleśny-Drabiniok

Vaz

et al. 2021

Neurobiology of Stress

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9- cis -13,14-dihydroretinoic acid (9CDHRA), acts as an endogenous ligand of the retinoid X receptors (RXRs), and is an active form of a suggested new vitamin, vitamin A5/X. Nutritional-relevance of this pathway as well as its detailed role in vertebrate physiology, remain largely unknown. Since recent GWAS data and experimental studies associated RXR-mediated signaling with depression, we explored here the relevance of RXR and vitamin A5/X-mediated signaling in the control of stress adaptation and depressive-like behaviors in mice. We found that compromised availability of 9CDHRA in Rbp1−/− mice was associated with increased despair in the forced swim and anhedonia in the sucrose preference test. 9CDHRA similarly to synthetic RXR agonist, BMS649, normalized despair behaviors in Rbp1−/− but not Rxrγ−/− mice, supporting involvement of RXR signaling in anti-despair activity of these ligands. Importantly, similarly to BMS649, the 9CDHRA and its nutritional-precursor, 9- cis -13,14-dihydroretinol (vitamin A5/X alcohol), prevented development of depressive-like behaviors in mice exposed to chronic social defeat stress, revealing the beneficial role of RXRs and its endogenous ligand in stress adaptation process. These data point to the need for relevant nutritional, biochemical and pharmacological studies of this signaling pathway in human, both in physiological conditions and in pathologies of stress-related disorders.

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Dietary vitamin A supplementation prevents early obesogenic diet-induced microbiota, neuronal and cognitive alterations

Cited by 24 publications

References 56 publications

Gut microbiota and vitamin status in persons with obesity: A key interplay

Gut microbiota and vitamin status in persons with obesity: A key interplay

Diet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner

Vitamin A5/X controls stress-adaptation and prevents depressive-like behaviors in a mouse model of chronic stress

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