Dietary Vitamin D Dependence of Cat and Dog Due to Inadequate Cutaneous Synthesis of Vitamin D

How, K.L.; Hazewinkel, H. A. W.; Mol, Jan A.

doi:10.1006/gcen.1994.1154

Cited by 200 publications

(161 citation statements)

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“…The diet represents the only source of vitamin D in cats because they are unable to produce vitamin D in the skin [57]. Based on feeding studies in the 1950s, the National Research Council proposed a minimum vitamin D requirement for growing kittens of 500 IU/kg of dietary dry matter [58].…”

Section: Increased Vitamin D Activity In Cats With Feline Odontoclastmentioning

confidence: 99%

Update on the Etiology of Tooth Resorption in Domestic Cats

Reiter

Lewis

Okuda

2005

Veterinary Clinics of North America: Small Animal Practice

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Feline odontoclastic resorptive lesions (FORL) were first recognized and histologically differentiated from caries in the 1920s [1,2]. Some anecdotal reports describing caries-like lesions at the cervical region of feline teeth followed in the 1950s and 1960s, until two microscopic studies in the 1970s again revealed that FORL were not caries but a type of tooth resorption [3,4]. A recent study showed that cats with FORL have a significantly lower urine specific gravity and significantly higher serum concentration of 25-hydroxyvitamin D (25OHD) compared with cats without FORL [5], indicating that multiple tooth resorption in domestic cats could be the manifestation of some systemic insult rather than a local cause. In this article, the histologic and radiographic appearance of FORL and certain other peculiarities of feline teeth are reviewed. An attempt is then made to compare these findings with changes of the periodontium induced by administration of excess vitamin D or vitamin D metabolites in experimental animals. Histologic and radiographic features of feline odontoclastic resorptive lesionsTooth resorption is caused by odontoclasts. Their precursors derive from hematopoietic stem cells of bone marrow or spleen and migrate from blood vessels of the alveolar bone or periodontal ligament toward the external root

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Section: Increased Vitamin D Activity In Cats With Feline Odontoclastmentioning

confidence: 99%

Update on the Etiology of Tooth Resorption in Domestic Cats

Reiter

Lewis

Okuda

2005

Veterinary Clinics of North America: Small Animal Practice

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“…Baja and increases PTH proteolysis. Accordingly, by increasing the concentration of extracellular iCa, the proportion of PTH Ct fragments secreted are increased (2,(3)(4)(5). While it was believed that these fragments had no biological activity, it has been demonstrated in humans and animals that some PTH Ct fragments have an opposite effect on blood concentration of iCa (5-7).…”

Section: Introductionmentioning

confidence: 99%

Reference values of parathyroid hormone and vitamin D Hormone by chemiluminescent automated assay

et al. 2015

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Objective. Provide reference data for parathyroid hormone 1-84 (PTH 1-84) and 25OH Vitamin D (25OH D) using a new technique. Materials and methods. The hormones were evaluated, in serum, using a third generation automated chemiluminescent method for PTH in a group of 60 adult dogs, clinically healthy, grouped according to age in years in GA: 1 to 5, GB: 6 to 10 and GC:>10. Results. Data expressed as average ± DS were for PTH (pg/ml): 9.3±2.3; 12±6.3; 12.2±3.7; and for 25OH D (ng/ml): 84.2±27.8; 68.2±16.0; 63.6±23.1, respectively. The PTH value was significantly greater (p<0.05) in groups B and C in comparison with A, but no significant differences were observed between GB and GC. The 25OH D concentration was significantly less in GB (p<0.05) and in GC (p<0.01) in comparison with GA, showing no differences between GB and GC. A negative correlation between 25OH D and PTH was found (r= -0.28; p=0.015). Conclusions. Data contributed by this study provide reference values for PTH 1-84 and 25OH D, evaluated using a third generation automated chemiluminescent method for PTH in local dogs. The results will facilitate monitoring diseases that alter the metabolism of calcium and phosphorus in dogs.Key Words: Calcium, phosphorus, parathyroid hormone, metabolism, vitamin D (Source: MeSH). RESUMENObjetivo. Aportar datos de referencia, para hormona paratiroidea 1-84 (PTH 1-84) y 25OH Vitamina D (25OH D) con una nueva técnica. Materiales y métodos. Las hormonas fueron valoradas, en suero, por un método quimioluminiscente automatizado, y de tercera generación para la PTH, en una población de 60 perros adultos clínicamente sanos, agrupados según edad en años en GA: 1 a 5, GB: 6 a 10 y GC:>10. Resultados. Los datos expresados como media ± DS fueron para la PTH (pg/ml): 9.3±2.3; 12±6.3; 12.2±3.7; y para la 25OH D (ng/ml): 84.2±27.8; 68.2±16.0; 63.6±23.1, respectivamente. El valor de PTH fue significativamente mayor (p<0.05) en los grupos B y C con respecto al A, pero no se observó diferencia significativa entre GB y GC. La concentración de 25OH D fue significativamente menor en el GB (p<0.05) y en el GC (p<0.01) con respecto al GA, sin haber diferencias entre los GB y GC. Se encontró una correlación negativa entre 25OH D y PTH (r= -0.28; p=0.015). Conclusiones. Los datos aportados en este trabajo permiten disponer de valores de referencia de PTH 1-84 y de 25OH D, valorados por un método quimioluminiscente automatizado y de tercera generación para la PTH, en una población local de perros. Los resultados facilitarán el seguimiento de enfermedades que alteran el metabolismo del calcio y fósforo en perros.Palabras clave: Calcio, fósforo, hormona paratiroidea, metabolismo, vitamina D (Fuente: MeSH).

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“…Dogs, unlike humans, cannot synthesize vitamin D from cholesterol precursors and ultraviolet irradiation at the level of the skin, making oral intake of either cholecalciferol or ergocalciferol a dietary requirement 30. On the basis of the dietary questionnaire used in this study, dogs with CHF did not show any difference in vitamin D intake when compared with unaffected controls, but there was more variation in intake in the CHF group.…”

Section: Discussionmentioning

confidence: 69%

“…In people, serum 25(OH)D concentrations reflect cumulative exposure to sunlight (ie, ultraviolet light) and dietary vitamin D 29. In dogs, serum vitamin D concentration is not influenced by ultraviolet light exposure, because dogs do not convert cutaneous 7‐dehydrocholesterol into vitamin D 3 as do many other species 30. This difference in environmental exposure leaves dietary intake as the primary means of obtaining vitamin D 2 or vitamin D 3 for conversion into 25(OH)D and thereby eliminating a potentially confounding variable during investigation.…”

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confidence: 99%

Relation of Vitamin D Status to Congestive Heart Failure and Cardiovascular Events in Dogs

Kraus

Rassnick

Wakshlag

et al. 2013

Veterinary Internal Medicne

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BackgroundVitamin D plays a pivotal role in cardiac function, and there is increasing evidence that vitamin D deficiency is associated with the development of congestive heart failure (CHF) in people.HypothesisSerum vitamin D concentration is lower in dogs with CHF compared with unaffected controls and serum vitamin D concentration is associated with clinical outcome in dogs with CHF.AnimalsEighty‐two client‐owned dogs.MethodsIn this cross‐sectional study, we examined the association between circulating 25‐hydroxyvitamin D [25(OH)D], a measure of vitamin D status, and CHF in dogs. In the prospective cohort study, we examined whether 25(OH)D serum concentration was associated with clinical outcome in dogs with CHF.ResultsMean 25(OH)D concentration (100 ± 44 nmol/L) in 31 dogs with CHF was significantly lower than that of 51 unaffected dogs (123 ± 42 nmol/L; P = .023). The mean calculated vitamin D intake per kg of metabolic body weight in dogs with CHF was no different from that of unaffected dogs (1.37 ± 0.90 μg/kg metabolic body weight versus 0.98 ± 0.59 μg/kg body weight, respectively, P = .097). There was a significant association of serum 25(OH)D concentration on time to clinical manifestation of CHF or sudden death (P = .02).Conclusion and Clinical RelevanceThese findings suggest that low concentrations of 25(OH)D may be a risk factor for CHF in dogs. Low serum 25(OH)D concentration was associated with poor outcome in dogs with CHF. Strategies to improve vitamin D status in some dogs with CHF may prove beneficial without causing toxicity.

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Dietary Vitamin D Dependence of Cat and Dog Due to Inadequate Cutaneous Synthesis of Vitamin D

Cited by 200 publications

References 0 publications

Update on the Etiology of Tooth Resorption in Domestic Cats

Update on the Etiology of Tooth Resorption in Domestic Cats

Reference values of parathyroid hormone and vitamin D Hormone by chemiluminescent automated assay

Relation of Vitamin D Status to Congestive Heart Failure and Cardiovascular Events in Dogs

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