Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study

Chouët, Justine; Ferland, Guylaine; Féart, Catherine; Rolland, Yves; Presse, Nancy; Boucher, Kariane; Barberger‐Gateau, Pascale; Beauchet, Olivier; Annweiler, Cédric

doi:10.3390/nu7085306

Cited by 59 publications

(43 citation statements)

References 30 publications

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“…8,9 A subsequent study by Presse and colleagues revealed that in cognitively intact elderly individuals, higher serum phylloquinone concentrations were correlated with enhanced verbal episodic memory and recollection tests. 10 More recently, studies of older adults have reported better cognitive function and behavioural rating among those in the highest quartile of dietary phylloquinone intake 11 and fewer and less severe subjective memory complaints among those with higher dietary intakes. 12 These findings however appear to be confined to older populations.…”

Section: Introductionmentioning

confidence: 99%

Vitamin K status and inflammation are associated with cognition in older Irish adults

Kiely

Ferland

Ouliass

et al. 2018

Nutritional Neuroscience

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Studies have shown associations between reduced vitamin K status and poor cognitive function. However, despite this apparent link, direct studies measuring cognitive function, vitamin K status and inflammation are lacking. In the current study, The ELDERMET cohort was investigated to identify associations between cognition, vitamin K status and inflammation. The primary aim of the ELDERMET study was to investigate the relationship between gut bacteria, diet, lifestyle and health in 500 older Irish adults. Significant differences in serum phylloquinone, dietary phylloquinone and inflammatory markers were found across varying levels of cognitive function, after controlling for sex, age, body mass index (BMI), triglycerides and blood pressure. In addition, significantly higher levels of dietary phylloquinone were found in those with better cognition compared to those with the poorest function. Higher levels of inflammatory were also associated with poor cognition. Furthermore, both dietary and serum phylloquinone were significant independent predictors of good cognitive function, after controlling for confounders. This study highlights the importance of dietary vitamin K as a potentially protective cognitive factor; it also provides evidence for the correlation between cognition and inflammation. Strategies should be devised by which elderly populations can access rich dietary sources of phylloquinone to maintain cognition.

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Section: Introductionmentioning

confidence: 99%

Vitamin K status and inflammation are associated with cognition in older Irish adults

Kiely

Ferland

Ouliass

et al. 2018

Nutritional Neuroscience

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“…Rats fed with a low vitamin K diet presented an altered sphingolipid profile in their hippocampus, which is the key cerebral region for memory [13]. Clinical studies on human subjects confirmed a positive association between, on the one hand, serum concentrations and dietary intake of vitamin K and, on the other hand, cognitive outcomes in healthy elderly [14][15][16]. e large number of geriatric patients on OAT has suggested the need for further investigations so as to understand whether treatments with any vitamin K antagonists may affect cognitive functions.…”

Section: Discussionmentioning

confidence: 83%

“…e role of vitamin K in coagulation processes has been extensively studied and characterised [29]. Recent studies have suggested that the vitamin may also play a key role in cognitive performance [13][14][15][16]. Studies on animal models have suggested that vitamin K may be involved in memory consolidation.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study

Alisi¹,

Cafolla

Gentili

et al. 2020

Journal of Aging Research

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Objectives. Recent studies have suggested that vitamin K may exert significant effects on the central nervous system. The present study investigates the relationship between vitamin K plasmatic levels and cognitive functions in elderly patients on oral anticoagulant therapy (OAT). Design. At the Thrombosis Centre of Haematology, “Sapienza” University of Rome, 85 patients on OAT, aged between 75 and 92, were randomly enrolled in the study. Patients were on OAT with vitamin K antagonists (VKAs). Vitamin K1 concentrations were determined using standardized High-Performance Liquid Chromatography (HPLC). Cognitive functions were assessed using the Milan Overall Dementia Assessment (MODA). Results. MODA scores are positively correlated to vitamin K1 concentration. Patients with vitamin K1 below 0.100 μg/L and between 0.100 and 0.400 μg/L showed a mean MODA score of 79 ± 5 and 82 ± 3, respectively. Patients with vitamin K1 above 0.400 μg/L had a significantly greater MODA score (89 ± 1). After binning the data into bicentiles, MODA scores are shown to be linearly dependent on vitamin K1 concentrations (p<0.001). Even long-term OAT (>10 years) does not affect MODA scores. Education seems to exert a greater role on the cognitive status in comparison with aging. Conclusions. The study shows a positive association between vitamin K1 concentration and cognitive status in elderly patients (≥75 years) on OAT. The relationship between vitamin K1 concentration and MODA scores is described by a linear model. Cognitive status is not influenced by the duration of OAT but by the years of education.

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“…Importantly, in addition to its role in blood coagulation, vitamin K is also involved in brain health and function [3] by regulating the synthesis of sphingolipids, a constituent of the myelin sheath and neuronal membrane [4], and the biological activation of vitamin K-dependent proteins (VKDPs) involved in neuron physiology and survival [4]. Epidemiological data support a positive association between serum vitamin K concentration and episodic memory function in older adults [5]; decreased dietary vitamin K intakes were also associated with more pronounced cognitive and behavioural disorders [6]. …”

Section: Introductionmentioning

confidence: 99%

Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study

Brangier¹,

Celle²,

Roche³

et al. 2018

Dement Geriatr Cogn Disord

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Background: Vitamin K antagonists (VKAs) are commonly used for their role in haemostasis by interfering with the vitamin K cycle. Since vitamin K also participates in brain physiology, this voxel-based morphometric study aimed to determine whether the duration of exposure to VKAs correlated with focal brain volume reduction in older adults. Methods: In this exposed/unexposed (1: 2) study nested within the GAIT (Gait and Alzheimer Interactions Tracking) cohort, 18 participants exposed to VKA (mean age 75 ± 5 years; 33.3% female; mean exposure 2,122 ± 1,799 days) and 36 matched participants using no VKA (mean age 75 ± 5 years; 33.3% female) underwent MRI scanning of the brain. Cortical grey and white matter volumes were automatically segmented using statistical parametric mapping. Age, gender, educational level, history of atrial fibrillation, type of MRI, and total intracranial volume were included as covariables. Results: The duration of exposure to VKA correlated inversely across the whole brain with the subvolumes of two clusters in the grey matter (right frontal inferior operculum and right precuneus) and one cluster in the white matter (left middle frontal gyrus). In contrast, the grade of white matter hyperintensities did not differ according to the use of VKA. Conclusion: We found focal atrophies in older adults exposed to VKA. These findings provide new insights elucidating the effects of VKAs on brain health and function in older adults.

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Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study

Cited by 59 publications

References 30 publications

Vitamin K status and inflammation are associated with cognition in older Irish adults

Vitamin K status and inflammation are associated with cognition in older Irish adults

Vitamin K Concentration and Cognitive Status in Elderly Patients on Anticoagulant Therapy: A Pilot Study

Use of Vitamin K Antagonists and Brain Morphological Changes in Older Adults: An Exposed/Unexposed Voxel-Based Morphometric Study

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