Dietary vitamins E and C and prostate cancer risk

Bidoli, Ettore; Talamini, Renato; Bosetti, Cristina; Negri, Eva; Lenardon, O.; Maso, Luigino Dal; Polesel, Jerry; Montella, Maurizio; Franceschi, Silvia; Serraino, Diego; Vecchia, Carlo La

doi:10.1080/02841860902946546

Cited by 26 publications

(13 citation statements)

References 32 publications

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“…Previous studies demonstrated that the increased level of oxidative stress (OS) causing prostate cancer, so micronutrient antioxidant could be effective in neutralizing the harmful effect of OS by involving in reactive oxygen species(ROS) elimination (Udensi and Tchounwou, 2016). The present finding seem to be consistent with other researches which found higher intake of dietary and supplementary vit E are inversely associated with risk of prostate cancer (Wright et al, 2007;Bidoli et al, 2009). However, some studies found no association or increased risk of prostate cancer with vitamin E (Gaziano et al, 2009;Klein et al, 2011).This discrepancy in results may be due to differences in baseline levels of OS.…”

Section: Discussionsupporting

confidence: 91%

“…Kirsh et al, (2006) revealed that risk of prostate cancer decreased by increasing dose and duration of vitamin E supplementation in current and recent smokers. In line with our results, a meta-analysis reported dietary vitamin C intake associated with reduced prostate cancer risk (Bai et al, 2015), while cohort and trial studies have found no association (Schuurman et al, 2002;Bidoli et al, 2009;Gaziano et al, 2009). It has been supposed that dietary fiber might decrease risk of prostate cancer by improving insulin sensitivity and decrease bioactivity of Insulin-like growth factor-1 IGF-1 (Barnard et al, 2002).…”

Section: Discussionsupporting

confidence: 89%

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Dietary Nutrient Patterns and Prostate Cancer Risk: A Case-Control Study from Iran

Bahrami

Movahed

Teymoori

et al. 2019

Asian Pac J Cancer Prev

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Background:Prostate cancer is the second common cancer in the world. Although some associations between dietary intakes and prostate cancer have been found, the effects of dietary nutrients interactions have not yet evaluated. The aim of this study is to assess the association between nutrient patterns and risk of prostate cancer.Methods and Materials:Ninety-seven patients with prostate cancer and 205 controls were asked about their demographic and dietary intakes using validated questionnaires. To extract nutrient patterns, Principal Component Analysis (PCA) based on the 35 nutrient items were applied. Varimax rotation was used for improving interpretation and minimizing correlation between the factors. Logistic regression was used to determine the odds ratio (OR) with 95% confidence interval (CI) of prostate cancer by higher scores on the nutrient patterns.Results:High adherence to the “plant source” pattern was negatively associated with prostate cancer risk (OR 0.29 for the highest vs. the lowest score tertile; 95% CI= 0.13 – 0.65; P value for trend: <0.003). Similarly, the “antioxidant and fiber” pattern was associated with decreasing risk of prostate cancer (OR 0.06 for the highest vs. the lowest score tertile;95% CI=0.02 – 0.19; P value for trend: <0.001). There was no significant association for the “mixed” and “vitamin and minerals” pattern with risk of prostate cancer.Conclusion:This study confirms the potential and important role of nutrients on prostate cancer risk. Our finding revealed that “antioxidant and fiber” and “plant source” pattern is inversely associated with prostate cancer risk; however, further longitudinal and trial studies are needed to make a firm conclusion.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

Dietary Nutrient Patterns and Prostate Cancer Risk: A Case-Control Study from Iran

Bahrami

Movahed

Teymoori

et al. 2019

Asian Pac J Cancer Prev

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“…The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC), found that alpha-tocopherol supplementation decreased risk of and mortality from prostate cancer [14];however, this effect was later found to be attenuated [19]. A beneficial effect of vitamin E was also observed in one prospective study [20], in which the effect was limited togamma-tocopherol, and three case control studies [22–24], whereas fourintervention studies [12–13], six prospective studies [15–19, 21], and two case control studies [25–26]found no effect.…”

Section: Antioxidants and Prostate Cancermentioning

confidence: 99%

“…Epidemiological research has shown vitamin C to protect against many types cancer [39]. However, only one intervention [13], two prospective [18, 21], and three case control [23–24, 26] studies of dietary or supplemental vitamin C and prostate cancer have been reported (Tables 1 and 2). Of these, two case control studies [23, 26] reported reduced prostate cancer risk associated with vitamin C intake, while other studies reported no association.…”

Section: Antioxidants and Prostate Cancermentioning

confidence: 99%

Dietary Antioxidants and Prostate Cancer: A Review

Vance

Fontham

et al. 2013

Nutrition and Cancer

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Prostate cancer is the most common non-cutaneous cancer in men in the United States. Several studies have examined the relationship between prostate cancer and antioxidants; however, the results of these studies are inconsistent. This article provides a systematic review of studies on prostate cancer and antioxidant intake from diet and supplements. Tea and coffee appear to offer protection against advanced prostate cancer. Different forms of vitamin E appear to exert different effects on prostate cancer, with alpha-tocopherol potentially increasing and gamma-tocopherol potentially decreasing risk of the disease. There is no strong evidence for a beneficial effect of selenium, vitamin C, or beta-carotene, while lycopene appears to be negatively associated with risk of the disease. The effect of dietary antioxidants on prostate cancer remains undefined and inconclusive, with different antioxidants affecting prostate cancer risk differentially. Further studies are needed to clarify the relationship between antioxidants and prostate cancer risk and to delineate the underlying mechanisms.

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“…And β-cryptoxanthin has been shown to be positively (47, 48), negatively (49), or not associated (50) with risk of prostate cancer. Previous studies on vitamin C and prostate cancer have observed no effect (31, 32, 41, 43, 47, 51, 52). There is limited evidence regarding dietary flavonoids, but in an Italian case-control study flavonoids were not associated with risk of prostate cancer (53).…”

Section: Discussionmentioning

confidence: 75%

Dietary Total Antioxidant Capacity is Inversely Associated with Prostate Cancer Aggressiveness in a Population-Based Study

Vance

Wáng

et al. 2016

Nutrition and Cancer

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The purpose of this study was to determine the relationship between total antioxidant capacity (TAC) from diet and supplements and prostate cancer aggressiveness among 855 African Americans (AA) and 945 European Americans (EA) in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Cases were classified as either high aggressive, low aggressive, or intermediate aggressive. TAC was calculated from the vitamin C equivalent antioxidant capacity of 42 antioxidants measured via food frequency questionnaire. EA reported greater dietary TAC from diet and supplements combined (P < 0.0001). In both minimally and fully adjusted logistic regression models, TAC from diet and supplements combined was associated with a reduced odds of high aggressive prostate cancer in all men, AA and EA: ORs for highest vs. lowest level (> 1500 vs. < 500 mg VCE/d): 0.31 (95% CI: 0.15, 0.67; P-trend < 0.01), 0.28 (95% CI: 0.08, 0.96; P-trend < 0.001), and 0.36 (95% CI: 0.15, 0.86; P-trend = 0.58), respectively. These associations did not appear to differ between AA and EA. These data suggest that greater intake of antioxidants is associated with less aggressive prostate cancer. Additional research is needed to confirm these results and determine the underlying mechanisms.

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Dietary vitamins E and C and prostate cancer risk

Cited by 26 publications

References 32 publications

Dietary Nutrient Patterns and Prostate Cancer Risk: A Case-Control Study from Iran

Dietary Nutrient Patterns and Prostate Cancer Risk: A Case-Control Study from Iran

Dietary Antioxidants and Prostate Cancer: A Review

Dietary Total Antioxidant Capacity is Inversely Associated with Prostate Cancer Aggressiveness in a Population-Based Study

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