Dietary whole Goji berry (<i>Lycium barbarum</i>) intake improves colonic barrier function by altering gut microbiota composition in mice

Tian, Baoming; Zhang, Ziqi; Zhao, Jianhua; Ma, Qingyu; Liu, Huicui; Nie, Chenxi; Ma, Zhiyuan; An, Wei; Li, Juxiu

doi:10.1111/ijfs.14606

Cited by 27 publications

(18 citation statements)

References 36 publications

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“…PrevotellaceaeUCG_001 is related to polysaccharide degradation and SCFA production (Heinritz et al ., 2016). SCFAs produced by gut microbiota play an important role to rectify metabolism and immunity (Tian et al ., 2020). These results showed that MBO consumption could increase the abundance of some benign bacteria.…”

Section: Resultsmentioning

confidence: 99%

Crude and refined millet bran oil alleviate lipid metabolism disorders, oxidative stress and affect the gut microbiota composition in high‐fat diet‐induced mice

Yin

Yousaf

et al. 2021

Int J of Food Sci Tech

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To investigate crude millet bran oil (MBO) and refined millet bran oil (MRO) consumption on lipid metabolism in obese mice, C57BL/6 mice were fed with HFD/MBO and MRO (2 g kg À1 bw per day) for 12 weeks. Both MBO and MRO supplementation effectively alleviated hepatic lipid accumulation, which was associated with downregulation of the expression levels of acetyl-CoA carboxylase (Acaca), fatty acid synthase (Fasn), perilipin-2 (Plin2) and stearoyl-CoA desaturase (Scd). Only MBO supplementation significantly decreased plasma levels of total cholesterol (TC), catalase (CAT), hepatic lipid peroxidation and hepatic oxidative stress. It also increased the abundance of Akkermansia. The refining process caused a reduction of bioactive components (phytosterols, tocopherols and pigments) and a decrease in associated health benefits of MBO. Therefore, MBO can be moderately refined and still retain some health benefits, but new refining methods are needed to enhance the content of active compounds and improve the physiological efficacy of MRO.

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Section: Resultsmentioning

confidence: 99%

Crude and refined millet bran oil alleviate lipid metabolism disorders, oxidative stress and affect the gut microbiota composition in high‐fat diet‐induced mice

Yin

Yousaf

et al. 2021

Int J of Food Sci Tech

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“…As a naturally occurring chemical, LBP is the water-soluble glycoconjugates with a molecular weight from 10-2300 kDa [15]. Due to their various pharmacological effects, including anti-oxidation, anti-aging, immune regulation, improvement of gut microbiota and reproductive protection [16][17][18][19][20][21], LBP has been widely exploited in healthy foods and medicine in China. Although the comprehensive pharmacological studies of LBP have been performed, there is still only limited information on the pharmacokinetics and excretion study of this compound in vivo given their high molecular size.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and Excretion Study of Lycium barbarum Polysaccharides in Rats by FITC-Fluorescence Labeling

Xia

Yang

Zhou

et al. 2021

Foods

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A high-performance gel permeation chromatography fluorescence detection (HPGPC-FD) method combined with fluorescein isothiocyanate (FITC) labeling was established for the microanalysis of L. barbarum polysaccharides (LBP). The calibration curves linear over the range of 0.2–20 µg/mL in rat plasma, and 0.25–500 μg/mL in urine and feces samples with correlation coefficients greater than 0.99. The inter-day and intra-day precisions (RSD, %) of the method were under 15% with the relative recovery ranging from 84.6% to 104.0% and the RSD ranging from 0.47% to 7.28%. The concentration–time curve of LBP-FITC in plasma following intragastric administration at 100, 50 and 25 mg/kg well fitted to a nonlinear model. LBP-FITC slowly eliminated from plasma according to the long half-lives (t1/2 = 31.39, 38.09, and 45.76 h, respectively) and mean retention times (MRT0–t = 18.38, 19.15 and 20.07 h, respectively; AUC0–∞ = 230.49, 236.18 and 242.57 h, respectively) after administration of LBP-FITC at doses of 100, 50, and 25 mg/kg, respectively. After intragastric administration at 50 mg/kg for 72 h, the concentration of LBP-FITC in urine and feces was 0.09 ± 0.04% and 92.18 ± 3.61% respectively; the excretion rate of urine was the highest in 0–4 h period and decreased continuously in 4–24 h period. The excretion rate of feces was the highest in 4–10 h, 48.28 ± 9.349% in feces within 4–10 h, and decreased rapidly in 10–24 h. The present study showed that LBP was absorbed as its prototype and most proportion of LBP was excreted from feces, indicating a long time remaining in intestine.

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“…Goji ( Lycium barbarum ) belongs to the Solanaceae family and its berry (also called wolfberry) is a well‐known traditional Chinese herbal medicine and valuable tonic food for centuries (Xie et al, 2016; Zhang et al., 2016). Medical research has evidenced their potential impact on human health, such as improving visual acuity, reducing blood sugar levels, decreasing the risk of cancer and cell senescence, improves colonic barrier function and improving immunity (Huang et al., 2019; Tian et al., 2020; Yao et al., 2018). Recently, further studies have been conducted to identify the bioactive ingredients of goji fruits and clarify their bioactivities.…”

Section: Introductionmentioning

confidence: 99%

Comparison of nutrients and microbial density in goji berry juice during lactic acid fermentation using four lactic acid bacteria strains

Wang

Ouyang

Liu

et al. 2020

J Food Process Preserv

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To study the effect of lactic acid fermentation of goji berry juice on the antioxidant activity and metabolism of sugars, organic acids, and amino acids, four different lactic acid bacteria were adopted in the fermentation and metabolites were analyzed. Results showed that all strains could grow well in goji berry juice and Lactobacillus brevis showed much better growth rate. Malic acid, was significantly metabolized by all bacteria. Lactic acid was detected as the most produced acidic metabolite during the fermentation, especially by Lactobacillus plantarum. In addition, inoculated with lactic acid bacteria could increase the content of biogenic amines and decrease the content of amino acids. Moreover, a significant increase of total polyphenol and antioxidant activity was found by inoculation with Lactobacillus acidophilus. Fermentation could lead to the goji berry juice more darkness, redness, yellowness, and saturation, which was more evident in L. acidophilus and L. plantarum fermented samples. Practical applications Goji (Lycium barbarum) has been cultivated in large scale with more than 200,000 t annual yield of its berry in China. However, a small percentage of them has been used for industrial processing. In the present study, four strains of lactic acid bacteria were used to ferment goji berry juice, and their growth and effect on the quality of the juice were compared. Our results will provide useful information for the development of new goji berry processing products.

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Dietary whole Goji berry (Lycium barbarum) intake improves colonic barrier function by altering gut microbiota composition in mice

Cited by 27 publications

References 36 publications

Crude and refined millet bran oil alleviate lipid metabolism disorders, oxidative stress and affect the gut microbiota composition in high‐fat diet‐induced mice

Crude and refined millet bran oil alleviate lipid metabolism disorders, oxidative stress and affect the gut microbiota composition in high‐fat diet‐induced mice

Pharmacokinetics and Excretion Study of Lycium barbarum Polysaccharides in Rats by FITC-Fluorescence Labeling

Comparison of nutrients and microbial density in goji berry juice during lactic acid fermentation using four lactic acid bacteria strains

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