Dietary wild bitter gourd displays selective androgen receptor modulator like activity and improves the muscle decline of orchidectomized mice

Abstract

Wild bitter gourd, like selective androgen receptor modulators (SARMs), restored the mass of androgen responsive muscles but not prostate and might improve skeletal muscle function in orchidectomized mice.

Testosterone Promotes the Proliferation of Chicken Embryonic Myoblasts Via Androgen Receptor Mediated PI3K/Akt Signaling Pathway

“…Skeletal muscle is the main source for proteins in animals and is one of the main organs involved in energy acquisition and maintenance. The weight and size of muscle mass respond very rapidly to hormone stimulation during anabolism or catabolism [19,20]. Previous study showed that androgens promoted muscle growth by maintaining myoblasts in the proliferate state and delaying the differentiation process [8].…”

“…In males, androgens acted through AR to regulate multiple signalling pathways that control muscle mass, strength and fatigue resistance [1]. Studies of muscle-specific ARKO mouse models provided evidence that a direct role of AR in hind limb muscles was to regulate their strength and fiber type distributions, and it was also a major muscle quality determinant [11,19]. In this study, the expression of endogenous AR mRNA increased gradually following embryonic development, and it was higher in females than that of males (p < 0.05).…”