Dietary xylitol supplementation prevents osteoporotic changes in streptozotocin-diabetic rats

Mattila, Pauli T.; Knuuttila, Matti; Svanberg, Martti

doi:10.1016/s0026-0495(98)90243-8

Cited by 29 publications

(20 citation statements)

References 32 publications

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“…From the data of this study, it has been concluded that an intake of xylitol in vivo did not cause problems with lipogenesis because of the suppression of a high-fat induced-visceral fat accumulation, and xylitol intake may be useful to control or prevent obesity, diabetes and other metabolic disorders. Although the effects of 10 and 20% dietary xylilol have been investigated previously [29,30], the objectives of these studies were completely different from the present study. Mattila et al [29] investigated the protective effects of 10 and 20% dietary xylitol on the loss of bone mineral and the weakening of bone biochemical properties, while Knuuttila et al [30] examined the effects of 10% dietary xylitol on collagen content and glycosylation, both in a streptozotocin-induced type 1 diabetes rat model.…”

Section: Introductionmentioning

confidence: 95%

“…Although the effects of 10 and 20% dietary xylilol have been investigated previously [29,30], the objectives of these studies were completely different from the present study. Mattila et al [29] investigated the protective effects of 10 and 20% dietary xylitol on the loss of bone mineral and the weakening of bone biochemical properties, while Knuuttila et al [30] examined the effects of 10% dietary xylitol on collagen content and glycosylation, both in a streptozotocin-induced type 1 diabetes rat model. However, the antidiabetic effect of xylitol either as a sugar substitute or as a supplement has not yet been examined in T2D either in humans or experimental animals.…”

Section: Introductionmentioning

confidence: 95%

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Effects of Xylitol on Blood Glucose, Glucose Tolerance, Serum Insulin and Lipid Profile in a Type 2 Diabetes Model of Rats

Islam

Indrajit²

2012

Ann Nutr Metab

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Background/Aims: The present study was conducted to examine the antidiabetic effects of xylitol in a type 2 diabetes rat model. Methods: Six-week-old male Sprague-Dawley rats were randomly divided into 3 groups: normal control (NC), diabetic control (DBC) and xylitol (XYL). Diabetes was induced only in the DBC and XYL animal groups by feeding them a 10% fructose solution for 2 weeks followed by an injection (i.p.) of streptozotocin (40 mg/kg body weight). One week after the streptozotocin injection, the animals with a nonfasting blood glucose level of >300 mg/dl were considered to be diabetic. The XYL group was fed further with a 10% xylitol solution, whereas the NC and DBC groups were supplied with normal drinking water. Results: After 5 weeks of intervention, food and fluid intake, body weight, blood glucose, serum fructosamine and most of the serum lipids were significantly decreased, and serum insulin concentration and glucose tolerance ability was significantly increased in the XYL group compared to the DBC group. Liver weight, liver glycogen and serum triglycerides were not influenced by feeding with xylitol. Conclusion: The data of this study suggest that xylitol can be used not only as a sugar substitute but also as a supplement to antidiabetic food and other food products.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 95%

Effects of Xylitol on Blood Glucose, Glucose Tolerance, Serum Insulin and Lipid Profile in a Type 2 Diabetes Model of Rats

Islam

Indrajit²

2012

Ann Nutr Metab

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“…is one of the most recent findings concerning the clinical applications of xylitol (Mattila et al, 1998;Uhari et al, 2001). Xylitol can be produced by chemical reduction of D-xylose, but this method involves expensive purification steps that can be avoided by using fermentation (Melaja & Hamalainen, 1997).…”

Section: Brazilian Journal Of Chemical Engineeringmentioning

confidence: 99%

Evaluation of the activated charcoals and adsorption conditions used in the treatment of sugarcane bagasse hydrolysate for xylitol production

Marton

Felipe

Silva

et al. 2006

Braz. J. Chem. Eng.

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-Xylitol has sweetening, anticariogenic and clinical properties that have attracted the attention of the food and pharmaceutical industries. The conversion of sugars from lignocellulosic biomass into xylitol by D-xylose-fermenting yeast represents an alternative to the chemical process for producing this polyol. A good source of D-xylose is sugarcane bagasse, which can be hydrolyzed with dilute acid. However, acetic acid, which is toxic to the yeast, also appears in the hydrolysate, inhibiting microbe metabolism. Xylitol production depends on the initial D-xylose concentration, which can be increased by concentrating the hydrolysate by vacuum evaporation. However, with this procedure the amount of acetic acid is also increased, aggravating the problem of cell inhibition. Hydrolysate treatment with powdered activated charcoal is used to remove or decrease the concentration of this inhibitor, improving xylitol productivity as a consequence. Our work was an attempt to improve the fermentation of Candida guilliermondii yeast in sugarcane bagasse hydrolysate by treating the medium with seven types of commercial powdered activated charcoals (Synth, Carbon Delta A, Carbon Delta G, Carbon 117, Carbon 118L, Carbon 147 and Carvorite), each with its own unique physicochemical properties. Various adsorption conditions were established for the variables temperature, contact time, shaking, pH and charcoal concentration. The experiments were based on multivariate statistical concepts, with the application of fractional factorial design techniques to identify the variables that are important in the process. Subsequently, the levels of these variables were quantified by overlaying the level curves, which permitted the establishment of the best adsorption conditions for attaining high levels of xylitol volumetric productivity and D-xylose-to-xylitol conversion. This procedure consisted in increasing the original pH of the hydrolysate to 7.0 with CaO and reducing it to 5.5 with H 3 PO 4 . Next, the hydrolysate was treated under adsorption conditions employing CDA powdered activated charcoal (1%) for 30 min at 60ºC, 100 rpm and pH 2.5. The optimized xylitol volumetric productivity (0.50 g/L h) corresponded to a D-xyloseto-xylitol conversion of 0.66 g/g.

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“…Sene et al (2001) observaram que a assimilação de arabinose por C. guilliermondii em hidrolisado hemicelulósico de bagaço de cana foi favorecida em condições de baixa aeração. Matos et al (2002) relataram que a arabinose favoreceu a bioconversão de xilose em xilitol por C. guilliermondii, quando o inóculo foi obtido de células cultivadas nessa fonte de carbono. Quanto à glicose, essa foi totalmente assimilada pela levedura nas primeiras horas de cultivo (dados não apresentados).…”

Section: Produção De Xilitol Em Hidrolisado De Casca De Aveiaunclassified

Avaliação da casca de aveia para produção biotecnológica de xilitol

et al. 2004

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Dietary xylitol supplementation prevents osteoporotic changes in streptozotocin-diabetic rats

Cited by 29 publications

References 32 publications

Effects of Xylitol on Blood Glucose, Glucose Tolerance, Serum Insulin and Lipid Profile in a Type 2 Diabetes Model of Rats

Effects of Xylitol on Blood Glucose, Glucose Tolerance, Serum Insulin and Lipid Profile in a Type 2 Diabetes Model of Rats

Evaluation of the activated charcoals and adsorption conditions used in the treatment of sugarcane bagasse hydrolysate for xylitol production

Avaliação da casca de aveia para produção biotecnológica de xilitol

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