Dietary β-conglycinin induces intestinal enteritis and affects glycerophospholipid and arginine metabolism in mirror carp (Cyprinus carpio)

Luo, Qiaohua; Zhou, Zuliang; Zhao, Jianhua; Xu, Hong; Limbu, Samwel Mchele; Xu, Qiyou

doi:10.1016/j.aquaculture.2023.739257

Cited by 10 publications

(6 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…32 In addition, there is growing evidence that inflammation is related to glycerophospholipid metabolism. Allergic asthma involves a variety of inflammatory cells PD00 can modulate glycerophospholipid and purine metabolic pathways to reduce allergic asthma inflammation, thereby improving the pathophysiological features of asthma 33 ; Dietary β-CG induced enterocolitis in different intestinal segments and altered glycerophospholipid metabolism and arginine biosynthesis pathways 34 ; OGPC down-regulated TNF-α induced IL-6 secretion in vitro, and OGPC associated with glycerophospholipid metabolism pathway was significantly reduced, and glycerophospholipid metabolism was the main metabolic pathway for IL-6 differential expression in rheumatoid arthritis patients 35 ; Sepsis is a severe inflammatory disease, and STV-Na significantly alters the synthesis of glycerophospholipid metabolism, among others thereby modulating inflammation in sepsis 36 ; by altering glycerophospholipid metabolism pathways, Herba patriniae significantly modulates lipid metabolism and inflammation levels, demonstrating the potential for antiatherosclerotic development. 37 At present, there is no report that AB is related to glycerophospholipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Maqin Xiaoke Granule Alleviates Acute Bronchitis Induced by Smoking Combined With Streptococcus pneumoniae by Regulating NLRP3/p38 MAPK/Glycerophospholipid Pathway

Men,

Liu,

Yang

et al. 2024

Natural Product Communications

View full text Add to dashboard Cite

Objective: To explore the efficacy and mechanism of action of Maqin Xiaoke Granules (MQs) in the treatment of acute bronchitis (AB). Methods: The rat model of AB was established by mixed smoke and Streptococcus pneumoniae nasal infection. The pathological changes of lung tissue and bronchus were observed by hematoxylin-eosin (HE) staining and scored. The mRNA expression levels of NOD-like receptor thermal protein domain associated protein 3 ( NLRP3) and p38 mitogen-activated protein kinase ( p38 MAPK) in lung tissue were detected by real-time fluorescence quantitative polymerase chain reaction, and the expression levels of inflammatory factors (tumor necrosis factor-α [ TNF-α], interleukin-6 [ IL-6], interleukin-1β [ IL-1β], interleukin-10 [ IL-10]) in serum and lung homogenate were detected by enzyme-linked immunosorbent assay. The therapeutic effect of MQ on rats with AB was preliminarily evaluated. Metabolic profiling of rat serum was performed by ultra high-performance liquid chromatography-quadrupole-time of flight-mass spectrometry/mass spectrometry, combining P < .05, variable important in projection > 1, fold change > 1.5 and screening for differential metabolites based on univariate and multivariate statistical analyses, and then analyzing the possible metabolic pathways with the help of MetaboAnalyst 5.0 database, to analyze the mechanism of MQ’s action on the treatment of AB at the metabolic level. Results: MQ significantly ameliorated the pathological injury of bronchial and lung tissues in model rats, reduced the mRNA levels of NLRP3 and p38 MAPK ( P < .05, .01), lowered the levels of TNF-α, IL-6, and IL-1β in serum and lung homogenates ( P < .05, .01), and elevated IL-10 in serum and lung homogenates ( P < .0001, .01) levels, and to regulate abnormal metabolites in rats with AB via the glycerophospholipid metabolic pathway. Conclusion: MQ significantly improved AB induced by mixed smoke combined with Streptococcus pneumoniae, and the mechanism of its induction may be related to the dysregulation of glycerophospholipid metabolism, and this study provides a reference for the rational clinical application of MQ.

show abstract

Section: Discussionmentioning

confidence: 99%

Maqin Xiaoke Granule Alleviates Acute Bronchitis Induced by Smoking Combined With Streptococcus pneumoniae by Regulating NLRP3/p38 MAPK/Glycerophospholipid Pathway

Men,

Liu,

Yang

et al. 2024

Natural Product Communications

View full text Add to dashboard Cite

show abstract

“…Then, pellets with 2 mm particle size were produced by using a twin screw extruder. The diets were dried in a ventilated oven at 40 °C and stored at -20 °C ( 3 ).…”

Section: Methodsmentioning

confidence: 99%

“…Soybean meal (SM) has become one of the main protein sources in aquatic feed because of its high protein content, relatively balanced amino acid composition and reasonable price. However, SM contains some anti-nutritional factors including trypsin inhibitors, antigen proteins, lectins, tannins, saponins and alkaloids ( 1 – 3 ). Previous studies on Atlantic salmon ( Salmo salar ) ( 4 , 5 ), zebrafish ( Danio rerio ) ( 6 ), rice field eel ( Monopterus albus ) ( 7 ), Japanese seabass ( Lateolabrax maculatus ) ( 8 ), largemouth bass ( 9 ) and Mirror carp ( Cyprinus carpio ) ( 10 ) have shown that, excessive use of SM in feed can cause intestinal inflammation and injury, intestinal digestion and absorption dysfunction, and ultimately reduce growth performance ( 11 , 12 ), especially in carnivorous fish.…”

Section: Introductionmentioning

confidence: 99%

Effects of tributyrin and alanyl-glutamine dipeptide on intestinal health of largemouth bass (Micropterus salmoides) fed with high soybean meal diet

et al. 2023

Self Cite

View full text Add to dashboard Cite

To investigate the effects of dietary tributyrin (TB) and alanyl-glutamine (AGn) on the intestinal health of largemouth bass (Micropterus salmoides) fed with high-level soybean meal (SM) diet, six isonitrogenous (41.36%) and isolipidic (10.25%) diets were formulated and fed to largemouth bass (initial body weight 25.5 ± 0.5g) for 8 weeks. The two control diets contained 34.8% peanut meal (PM) and 41.3% SM, while the other four experimental diets supplemented TB at 0.1% (TB0.1), 0.2% (TB0.2) and AGn at 1% (AGn1), 2% (AGn2) in SM, respectively. The results showed that there were no significant differences in weight gain, survival rate, and hepatosomatic index among all groups (P>0.05), while feed coefficient rate in AGn1, AGn2 and TB0.2 groups was significantly lower than that in SM group (P< 0.05). Compared with the PM group, the intestinal inflammation of largemouth bass in SM group were obvious, accompanied by the damage of intestinal structure, the decrease of digestive enzyme activity, and the up-regulation of proinflammatory cytokines. Compared with the SM group, the activities of intestinal trypsin, lipase and foregut amylase in TB and AGn groups increased significantly (P<0.05), and the gene expression levels of acetyl-CoA carboxylase (ACC), caspase-3, caspase-8, caspase-9, tumor necrosis factor alpha (TNF-α), and interleukin-1 beta (IL-1β) were down-regulated, while the gene expression levels of target of rapamycin (TOR) and eIF4E-binding protein (4E-BP) were up-regulated in all experimental groups (P<0.05). It can be concluded that supplementation of 1%-2% AGn and 0.1%-0.2% TB can alleviate enteritis caused by high-level soybean meal, and the recommend level is 2% AGn and 0.2% TB.

show abstract

“…These additives are nutritional/non-nutritional compounds provided in fish diets that enhance the physicochemical properties of diets or the performance of the target species (12,13). Previous research suggests that a myriad of additives exhibit beneficiary properties such as antiinflammatory, antioxidant, and immunomodulatory and may thus have the capacity to relieve SBMIE symptoms by strengthening the anti-inflammatory and immune responses of fish (14)(15)(16). Curcumin and berberine are both traditional herbal extracts, which can enhance intestinal villus development in Nile tilapia (Oreochromis niloticus) (17) and protect the intestinal barrier function of fish by regulating the intestinal microbiota (18).…”

Section: Introductionmentioning

confidence: 99%

Reparative effect of different dietary additives on soybean meal-induced intestinal injury in yellow drum (Nibea albiflora)

Ma,

Wang,

Zeng

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Soybean meal (SBM) is an acceptable replacement for unsustainable marine fish meal (FM) in aquaculture. However, we previously reported that high dietary SBM supplementation causes intestinal inflammatory injury in yellow drum (Nibea albiflora). Accordingly, a 4-week SBM-induced enteritis (SBMIE) in yellow drum trial was conducted first, followed by a 4-week additive-supplemented reparative experiment to evaluate the reparative effect of five additives on SBMIE in yellow drum. The control diet comprised 50% FM protein substituted with SBM. The additive-supplemented diet was added with 0.02% curcumin (SBMC), 0.05% berberine (SBM-BBR), 0.5% tea polyphenols (SBM-TPS), 1% taurine (SBM-TAU), or 0.8% glutamine (SBM-GLU) based on the control diet, respectively. The weight gain (WG), specific growth rate (SGR), feed efficiency ratio (FER), and survival rate (SR) of fish fed the additive-supplemented diets were significantly higher than those of fish fed the SBM diet. The WG, SGR, and FER of fish fed the SBMC, SBM-GLU and SBM-TAU diets were significantly higher than those of fish fed other diets. Moreover, fish fed the additive-supplemented diets SBMC and SBM-GLU, exhibited significantly increased intestinal villus height (IVH), intestinal muscular thickness (IMRT), and intestinal mucosal thickness (IMLT) and significantly decreased crypt depth (CD) in comparison with those fed the SBM diets. The relative expression of intestinal tight junction factors (ocln, zo1), cytoskeletal factors (f-actin, arp2/3), and anti-inflammatory cytokines (il10, tgfb) mRNA was remarkably elevated in fish fed additive-supplemented diets than those of fish fed the SBM diet. Whereas, the relative expression of intestinal myosin light chain kinase (mlck) and pro-inflammatory cytokines (il1, il6, tnfa) mRNA was markedly lower in fish fed the additive-supplemented diets. The highest relative expression of intestinal ocln, f-actin, and arp2/3 and the lowest relative expression of intestinal mlck were found in fish fed the SBMC diet. Hence, all five dietary additives effectively repaired the intestinal injury induced by SBM, with curcumin exhibiting the strongest repair effect for SBMIE in yellow drum.

show abstract

Dietary β-conglycinin induces intestinal enteritis and affects glycerophospholipid and arginine metabolism in mirror carp (Cyprinus carpio)

Cited by 10 publications

References 65 publications

Maqin Xiaoke Granule Alleviates Acute Bronchitis Induced by Smoking Combined With Streptococcus pneumoniae by Regulating NLRP3/p38 MAPK/Glycerophospholipid Pathway

Maqin Xiaoke Granule Alleviates Acute Bronchitis Induced by Smoking Combined With Streptococcus pneumoniae by Regulating NLRP3/p38 MAPK/Glycerophospholipid Pathway

Effects of tributyrin and alanyl-glutamine dipeptide on intestinal health of largemouth bass (Micropterus salmoides) fed with high soybean meal diet

Reparative effect of different dietary additives on soybean meal-induced intestinal injury in yellow drum (Nibea albiflora)

Contact Info

Product

Resources

About